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1.
Scand J Public Health ; 38(5): 495-501, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20529964

RESUMO

AIMS: Various types of musculoskeletal disorders (MSDs) have comorbid mental disorders, which may in turn have a negative influence on disease course and role impairment, but the contribution of social factors to this type of comorbidity is a much under-researched area. This study investigates whether there is a socially patterned association of MSDs with different dimensions of mental malaise. METHODS: The sample included 3,368 economically active participants aged 18-64 years, randomly selected from the Lorraine region in north-eastern France. Information was provided through a post-mailed questionnaire on fatigue, sadness/depression (Duke questionnaire) and cognitive disability during the last eight days. RESULTS: MSDs were significantly more prevalent in manual workers, clerks and other occupations than in upper and intermediate professionals, and similar occupational disparities were found for cognitive disability, fatigue and sadness/ depression. Stratifying the sample, we found the occupational disparities in cognitive disability to be much stronger among participants suffering from MSDs than among participants not suffering from MSDs, and the occupational disparities in fatigue and sadness/depression to be limited to the subsample of subjects suffering from MSDs. CONCLUSIONS: The findings demonstrate that the association of MSDs with mental malaise is much stronger in the lower occupational groups than in the higher groups. Given that psychological factors are implicated in disease prognosis and in the development of disabilities, awareness of the social dimension of the association and treatment of the comorbid mental disorders could open a promising avenue for reducing social inequalities in disability related to MSDs.


Assuntos
Transtornos Mentais/epidemiologia , Doenças Musculoesqueléticas/epidemiologia , Fatores Socioeconômicos , Adaptação Psicológica , Adolescente , Adulto , Idoso , Transtornos Cognitivos/complicações , Depressão/complicações , Fadiga/complicações , Feminino , França/epidemiologia , Humanos , Masculino , Transtornos Mentais/complicações , Pessoa de Meia-Idade , Doenças Musculoesqueléticas/complicações , Doenças Musculoesqueléticas/psicologia , Doenças Profissionais/epidemiologia , Doenças Profissionais/psicologia , Ocupações , Transtornos Psicofisiológicos/epidemiologia , Transtornos Psicofisiológicos/psicologia , Inquéritos e Questionários , Adulto Jovem
2.
Occup Environ Med ; 67(3): 147-53, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-19737734

RESUMO

OBJECTIVES: Because work-related injuries are common and yet the mechanisms through which various types of injuries relate to age, length of service and job remain unknown, this study assessed the role of age, length of service and job in work-related injury. METHODS: Prospective study of all 164,814 permanently employed male workers at the French national railway company during 1998-2000, based on the company's injury database: 446,120 person-years, 15,195 injuries with working days lost, coded using the company's injury classification, which is derived from that of the French health insurance scheme. We investigated the incidence of 10 types of injury: fall on same level, fall to lower level, handling materials/machine parts during assembly, handling objects, lifting/handling equipment, collision with/by moving objects, collision with/by vehicles, operating machines/equipment, using hand tools and other injuries. Data were analysed using negative binomial regression. RESULTS: Workers aged <25 years were subject to a higher injury risk from handling materials/machine parts during assembly, and collision with/by moving objects or vehicles. Older workers, especially those aged 50-55 years, were subject to a higher risk of fall and injury resulting from lifting/handling materials/equipment/objects or from collision with/by moving objects/vehicles. Using hand tools was a risky task for workers aged <30 or > or =40 years. The relative risk decreased steadily with increasing length of service with the company, from 2.6 for 1 year to 1.0 for > or =30 years, and the slope of the trend is stronger for fall to lower level, lifting/handling materials/equipment and collision with/by moving objects. CONCLUSION: Younger and older ages and shorter length of service are at risk for various types of injuries. Preventive measures should improve working conditions, especially for younger/older ages, provide knowledge through specific training during the first years in a job and help workers to be more aware of risks associated with their age, years of employment and job.


Assuntos
Acidentes de Trabalho/estatística & dados numéricos , Emprego/estatística & dados numéricos , Doenças Profissionais/epidemiologia , Ferrovias/estatística & dados numéricos , Ferimentos e Lesões/epidemiologia , Adulto , Fatores Etários , França/epidemiologia , Humanos , Indústrias , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/etiologia , Estudos Prospectivos , Fatores de Risco , Adulto Jovem
3.
Occup Environ Med ; 66(3): 175-81, 2009 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18805881

RESUMO

OBJECTIVE: To study the possible association between iron oxide exposures and lung cancer risk among workers in a French carbon steel-producing factory. METHODS: 16 742 males and 959 females ever employed for at least 1 year between 1959 and 1997 were followed up for mortality from January 1968 to December 1998. Causes of death were ascertained from death certificates. Job histories and smoking habits were available for 99.7% and 72.3% of subjects, respectively. Occupational exposures were assessed by a factory-specific job-exposure matrix (JEM) validated with atmospheric measurements. Standardised mortality ratios (SMRs) were computed using local death rates (external references). Poisson regressions were used to estimate the relative risks (RRs) for occupational exposures (internal references), adjusted on potential confounding factors. RESULTS: Among males, observed mortality was lower than expected for lung cancer compared to the local population (233 deaths, SMR 0.89, 95% CI 0.78 to 1.01) and higher than expected compared to the French population (SMR 1.30, 95% CI 1.15 to 1.48) No lung cancer excess was observed for exposure to iron oxides (RR 0.80, 95% CI 0.55 to 1.17) and no dose-response relationship with intensity, duration of exposure or cumulative index was found. A significant bladder cancer excess was observed among workers exposed to oil mist (RR 2.44, 95% CI 1.06 to 5.60), increasing significantly with intensity, duration of exposure and cumulative index. CONCLUSION: This study did not detect any relationship between exposure to iron oxides and lung cancer mortality. An excess of mortality from bladder cancer was found among workers exposed to oil mist.


Assuntos
Carcinoma/mortalidade , Compostos Férricos/toxicidade , Neoplasias Pulmonares/mortalidade , Metalurgia , Doenças Profissionais/mortalidade , Aço , Adulto , Carcinoma Pulmonar de Células não Pequenas/mortalidade , Monitoramento Ambiental/métodos , Feminino , Seguimentos , França , Humanos , Masculino , Exposição Ocupacional , Ocupações , Óleos/toxicidade , Análise de Regressão , Medição de Risco/métodos , Carcinoma de Pequenas Células do Pulmão/mortalidade , Fumar/efeitos adversos , Neoplasias da Bexiga Urinária/mortalidade
5.
Int Arch Occup Environ Health ; 81(4): 379-89, 2008 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17701420

RESUMO

OBJECTIVES: To assess the roles of job demands, living conditions and lifestyle in occupational injury. METHODS: The sample included 2,888 workers, aged > or =15 years, randomly selected from the north-eastern France. The subjects completed a mailed questionnaire. Data were analyzed with adjusted odds ratios (ORa) computed with the logistic model. RESULTS: In total, 9.2% of workers had an injury during the previous 2 years. The high job demands: tasks at height, handling objects, pneumatic tools, other vibrating hand tools, work in adverse climate, physical workload, vibrating platform, machine tools, cold, heat, awkward posture, noise, hammer, and pace had crude odds ratios between 1.81 and 5.25 for injury. A strong exposure-response relationship was found between the cumulated job demands (CJD, defined by their number) and injury: OR 1.88 (95% CI 1.23-2.87) for CJD1, 4.39 (2.98-4.46) for CJD2-3, and 9.93 (6.70-14.7) for CJD > or = 4, versus CJD0. These ORs decreased to 1.68, 3.70, and 7.15 respectively, when adjusted for sex, age, and living conditions/lifestyle confounders; and to 1.54, 2.99, and 5.45 respectively when also adjusted for job category. The following factors had significant ORa: age <30 years (1.54, 1.12-2.12), male (1.64, 1.18-2.30), smoking (1.60, 1.22-2.10), musculoskeletal disorders (1.54, 1.17-2.04), and frequent drug use for fatigue (2.03, 1.17-3.53). The workmen, farmers/craftsmen/tradesmen, and foremen had a 5.7-8.7-fold while the clerks and technicians a 2.7-3.6-fold higher risk compared with upper class. The risk associated with CJD was twofold higher among the workers aged > or =40 or with frequent drug use for fatigue compared with the others. Obesity had ORa 2.05 (1.11-3.78) among the subjects aged > or =40, and excess alcohol use had ORa 2.44 (1.26-4.72) among those free of disease. CONCLUSIONS: This study identified a wide range of job demands and living conditions/lifestyle which predicted injury. Preventive measures should be conducted to reduce job demands and to help workers to be aware of the risk and to improve their living conditions/lifestyle.


Assuntos
Acidentes de Trabalho/estatística & dados numéricos , Estilo de Vida , Doenças Profissionais/epidemiologia , Ocupações/estatística & dados numéricos , Adolescente , Adulto , Fatores Etários , Idoso , Feminino , Comportamentos Relacionados com a Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/etiologia , Fatores Sexuais
6.
Rev. Asoc. Esp. Espec. Med. Trab ; 15(3): 136-150, oct. 2006. tab
Artigo em Es | IBECS | ID: ibc-70273

RESUMO

Las enfermedades profesionales afectan a numerosos trabajadores y tienen un importante impacto socioeconómico. Sin embargo, dentro de la unión europea existen diferencias muy considerables entre los sistemas aplicados por los distintos estados miembros. El presente trabajo examina pormenorizadamente las diferencias entre los sistemas español y francés y evalúa los conocimientos al respecto de trabajadores que han padecido una enfermedad profesional, de médicos del trabajo y de la atención primaria, de empresarios y delegados de prevención y/o de miembros de los comités de seguridad y salud, y examina sus opiniones acerca del procedimiento de declaración de una enfermedad profesional y de quién debe declararla


Occupational diseases affect a large number of workers and have a considerable socioeconomic impact. However, within the European union quite considerable differences do exist between the systems applied by the various member states. The present paper examines in detail the differences between the French and Spanish systems and assesses the level of knowledge of workers who have suffered an occupational disease, of occupational health and primary health care physicians, employers, prevention delegates and/or members of the occupational safety and health committees, and examines their opinions regard-ing the procedure for the declaration of an occupational disease and regarding who should perform such a declaration


Assuntos
Humanos , Doenças Profissionais/epidemiologia , Notificação de Doenças/normas , França/epidemiologia , Espanha/epidemiologia , Inquéritos Epidemiológicos
8.
Occup Med (Lond) ; 56(3): 187-90, 2006 May.
Artigo em Inglês | MEDLINE | ID: mdl-16452131

RESUMO

BACKGROUND: Accident proneness or workers who have more frequent occupational injuries is common but the role of occupational and individual factors has rarely been studied. AIM: To assess the relationships of certain occupational and individual characteristics with frequency of occupational injuries. METHOD: This case-control study included 1305 male workers with occupational injuries during 1999-2000 and 1305 controls from a railway company. A standardized questionnaire was completed by the occupational physician in the presence of the subject. The data were analysed using logistic regression. RESULTS: Having more than one injury was associated with short service in the present job, younger age, sleep disorders, smoking, requesting a job change, physical disability and lack of physical activity. Safety training was negatively related to injury frequency. Short service in the present job was the only significant factor for single injuries. CONCLUSION: This study identified a number of work and individual factors that predicted occupational injury frequency and may be useful in designing preventative measures. Occupational physicians could assist workers to be more aware of the risks and to find remedial measures.


Assuntos
Propensão a Acidentes , Acidentes de Trabalho/estatística & dados numéricos , Ferrovias , Acidentes de Trabalho/prevenção & controle , Adulto , Estudos de Casos e Controles , França/epidemiologia , Humanos , Masculino , Fatores de Risco
9.
Rev Epidemiol Sante Publique ; 53(6): 614-28, 2005 Dec.
Artigo em Francês | MEDLINE | ID: mdl-16434934

RESUMO

BACKGROUND: Population ageing and longer duration of the working career could increase the prevalence of impairments and disabilities whereas there have been few data to help prevention and care. This study aimed at describing the prevalence of various types of impairments and assessing their social inequalities in the Lorraine population (north-eastern France). METHODS: The sample included 6.214 subjects aged 15 or more from 8.000 households randomly selected in the Lorraine population. A mailed questionnaire including socio-demographical characteristics, job, and various types of impairments was used. The data were analysed with the chi2 independence test, the adjusted odds ratio (OR) and the Mantel-Haenszel test. RESULTS: The prevalence of at least one impairment was 30% in both sexes. It varied from about 20% for subjects aged less than 40 years to about 60% for the subjects aged 70 years or more. It was higher in men than in women among the individuals aged more than 50 years (OR adjusted on age: 1.22, 95% CI: 1.04-1.44). The impairments were generally multiple for the subjects aged over 50. The prevalence of at least one impairment was higher for workmen (OR adjusted on age: 2.11, 95% CI: 1.68-2.66), farmers, craftsmen, traders and heads of firms (OR adjusted on age: 1.60, 95% CI: 1.17-2.18) and for employees (OR adjusted on age: 1.62, 95% CI: 1.29-2.03) in comparison with executives, intellectual professionals and teachers. For workmen a higher prevalence was observed for all types of impairments: intellectual and psychological functions, language, hearing, vision, visceral functions, and skeleton and posture. Farmers, craftsmen, traders, heads of firms and employees showed an excess for most types of impairments. Social inequalities were significant for various age groups during their period of occupational activity, but not after retirement. Unemployed people also had an excess of impairments. CONCLUSION: The prevalence of impairments strongly increased with advancing age. Marked inequalities were observed between various socio-occupational categories. Men were more affected than the women over 50 years of age. Impairments represent a health index which is useful for prevention to reduce their causes and consequences.


Assuntos
Transtornos Psicomotores/epidemiologia , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Avaliação da Deficiência , Feminino , França/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Seleção de Pacientes , Prevalência , Fatores Sexuais , Classe Social , Inquéritos e Questionários
10.
Rev. ortop. traumatol. (Madr., Ed. impr.) ; 48(1): 45-48, ene. 2004. ilus, tab
Artigo em Es | IBECS | ID: ibc-29475

RESUMO

Objetivo. Valorar biomecánica y clínicamente una técnica alternativa quirúrgica para el tratamiento de la pseudoartrosis del tercio medio de la clavícula. Material y método. Estudio mecánico: diecinueve especímenes de clavículas humanas fueron divididos en tres grupos: grupo A, 5 clavículas intactas, grupo B, 5 clavículas osteotomizadas perpendicularmente al eje longitudinal del hueso, en su parte media, y tratadas con placas DCP de 3,5 mm y 6 orificios, y grupo C, 9 clavículas osteotomizadas y tratadas con clavo canulado de Herbert, de 4,5 mm. Todas las clavículas fueron sometidas a ensayos mecánicos en una máquina de ensayos servohidraúlica obteniendo la resistencia máxima (N), la rigidez (N/Mm) y la tensión máxima (Mpa). Resultados. Estudio mecánico: tanto la placa recta DCP como el tornillo canulado de Herbert se comportaron mecánicamente de forma similar. Conclusiones. La ventaja de la síntesis intramedular con tornillo canulado de Herbert es que no requiere una segunda operación para retirar el implante una vez conseguida su consolidación (AU)


Assuntos
Humanos , Pseudoartrose/cirurgia , Clavícula/fisiopatologia , Parafusos Ósseos , Procedimentos Ortopédicos/métodos , Fenômenos Biomecânicos
11.
Occup Environ Med ; 60(5): 330-5, 2003 May.
Artigo em Inglês | MEDLINE | ID: mdl-12709517

RESUMO

BACKGROUND: Falls are frequent occupational accidents, and are responsible for a significant amount of lost working time and, more importantly, for a high mortality. The factors involved in falling mechanisms can be of external or individual origin, the latter being less well identified. AIMS: To assess the relations between certain individual characteristics and occupational accidents due to imbalance. METHODS: A total of 427 male employees, who had been victims of at least one occupational accident with sick leave due to imbalance (cases) and 427 controls were recruited among the employees of a large French railway company. A standardised questionnaire on life conditions and professional factors, and a description of the accidents was filled in by an occupational physician for each subject. RESULTS: Some job categories were more affected by a specific release mechanism of work related falls. Certain individual characteristics such as smoking, alcohol consumption, inactivity, sleep disorders, and request for a job change were correlated with the occurrence of occupational accidents. Sick leaves of eight days or over were more frequent in older and overweight injured workers. Some lesions were linked with the specific fall released mechanisms. CONCLUSIONS: Individual characteristics can increase the risk of occupational accidents, especially falling. This study identified subjects most at risk on whom prevention related to working conditions and falls could be focused.


Assuntos
Acidentes por Quedas/prevenção & controle , Acidentes de Trabalho/prevenção & controle , Postura/fisiologia , Propensão a Acidentes , Adulto , Fatores Etários , Estudos de Casos e Controles , França/epidemiologia , Nível de Saúde , Humanos , Descrição de Cargo , Acontecimentos que Mudam a Vida , Masculino , Pessoa de Meia-Idade , Equilíbrio Postural/fisiologia , Ferrovias , Licença Médica
12.
Rev Esp Cardiol ; 54(1): 16-21, 2001 Jan.
Artigo em Espanhol | MEDLINE | ID: mdl-11141450

RESUMO

INTRODUCTION AND OBJECTIVES: This study was performed to evaluate the feasibility and utility of a transthoracic high frequency transducer to detect and measure the left anterior descending coronary artery flow in patients with lesions in this artery or anterior myocardial infarction. MATERIALS AND METHODS: We studied 11 subjects with lesions greater than 75% and another 10 with anterior myocardial infarction. We compared the results with a control group of 18 subjects. An ATL HDI 5000 ultrasound unit with a 5-8 MHz transducer was used to identify the left anterior descending in the anterior interventricular sulcus from an apical four chamber window. We considered that left anterior descending was detected when a diastolic predominant flow pattern was obtained with pulse Doppler. RESULTS: Left anterior descending was detected in 37/39 of cases (94.4%). Patients with coronary lesions showed a decrease in the limit of significance in the diastolic/systolic peak velocity ratios: 2.5 (SD 0.7) vs 1.8 (SD 0.3) with a p = 0.024. Patients with anterior myocardial infarction obtained lower diastolic/systolic peak velocity ratios than controls: 2.5 (SD 0.7) vs 1.4 (SD 0.3) with a p = 0.001. CONCLUSIONS: Left anterior descending coronary artery flow can be assessed by transthoracic high frequency echocardiography in greater than 90% of the cases. Patients with coronary lesions and those with anterior myocardial infarction have a decreased diastolic/systolic peak velocity ratio.


Assuntos
Vasos Coronários/diagnóstico por imagem , Ecocardiografia Transesofagiana/instrumentação , Infarto do Miocárdio/diagnóstico por imagem , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
13.
Ergonomics ; 44(14): 1330-9, 2001 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-11900422

RESUMO

Falls are frequent occupational accidents involving workers and lead to important social and economic consequences both for the individual and for the employer. Different factors can modify balance control and lead to falling, especially environment-related and individual factors. The literature would appear to indicate that there have been few studies on the intrinsic factors involving the mechanisms of generating falls. This review determines the main factors involved in the mechanisms of falling, whether related to the environment, work or the individual. Knowledge of the extrinsic and intrinsic factors contributing to the fall could allow securer environment planning and occupational conditions for employers, and the use of balance rehabilitation methods for individuals to reduce the risk of falls.


Assuntos
Acidentes por Quedas/prevenção & controle , Acidentes de Trabalho/prevenção & controle , Ergonomia , Planejamento Ambiental , Humanos , Equilíbrio Postural/fisiologia , Postura/fisiologia
14.
Infect Control Hosp Epidemiol ; 21(9): 564-74, 2000 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11001259

RESUMO

OBJECTIVE: To describe the behavior of French nurses after occupational exposure to blood (OEB); to study the reasons for not reporting an OEB to the occupational medicine service or the hospital authorities, and to explore the links between personality traits and both the risk of having an OEB and the likelihood of reporting it. DESIGN: A descriptive and correlational study using a cross-sectional survey for data collection. SETTING: Six nursing schools (four initial training institutes and two specialty training schools, one for surgical nurses and one for nurse anesthetists) and six hospitals in Lorraine. PARTICIPANTS: 942 nurses and 459 nursing students were approached, and 964 (69%) replied to the questionnaire. METHODS: The participants received an anonymous two-part questionnaire. The first part explored the knowledge of the risk and Standard Precautions and collected details of the history of OEB. Reporting of OEB to the occupational medicine service or the hospital authorities and the nature of serological monitoring after OEB also were explored. The second part was composed of the Zuckerman sensation-seeking scale, exploring four areas: disinhibition, danger- and adventure-seeking, seeking new experiences, and susceptibility to boredom. RESULTS: 947 nurses were vaccinated against hepatitis B, but only 528 (56%) had checked that they were effectively immunized. Only 166 respondents (17%) stated they routinely used gloves during all procedures in which they were exposed to blood. There were 505 recorded OEB during the study period (0.24 per person per year). The most frequently reported OEB were those involving hollow needles (57%). Approximately one half (48.5%) of all OEB were reported. "Good local antisepsis immediately after the accident" was the reason most often given to justify nonreporting. Only 57% of OEB victims sought to determine the serological status of the source patient for human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus immediately after accident. Only 40% and 31% of OEB victims checked their own HIV and HCV serostatus 3 and 6 months after OEB, respectively. Few staff adopted safer-sex measures after OEB, and some continued to donate blood in subsequent months. Logistic regression identified two variables significantly and independently linked to the risk of having at least one OEB in the 27 months preceding the date on which the questionnaire was completed: having a permanent position and having a higher degree of disinhibition. Taking into account the number of OEB during this period (Poisson regression), four variables were significantly and independently linked to the risk of having a larger number of OEB: having a permanent position; having a higher degree of disinhibition; being more susceptible to boredom; and having less nursing experience. In logistic regression, three variables emerged as being significantly and independently linked to reporting all OEB: younger age; having had at least one percutaneous injury (excluding splashes); and having lower susceptibility to boredom. CONCLUSION: Nursing personnel continue to ignore or be unaware of many factors surrounding OEB, meaning that information and counseling must continue unabated. Knowledge of the risk, of the benefit of respecting Standard Precautions, and of the importance of notification and serological follow-up is still inadequate. Finally, certain personality traits, such as a high level of disinhibition and susceptibility to boredom, appear to be linked to the risk of OEB. Subjects strongly susceptible to boredom are less likely to report such accidents.


Assuntos
Patógenos Transmitidos pelo Sangue , Ferimentos Penetrantes Produzidos por Agulha , Recursos Humanos de Enfermagem Hospitalar/psicologia , Exposição Ocupacional , Personalidade , Revelação da Verdade , Síndrome da Imunodeficiência Adquirida/transmissão , Adolescente , Adulto , Educação Continuada , Feminino , França , Fidelidade a Diretrizes , Conhecimentos, Atitudes e Prática em Saúde , Hepatite B/transmissão , Hepatite C/transmissão , Humanos , Masculino , Pessoa de Meia-Idade , Saúde Ocupacional , Assunção de Riscos , Comportamento Sexual
15.
Scand J Med Sci Sports ; 10(5): 292-7, 2000 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-11001397

RESUMO

Although high-level sports develop specific physiological and sensorimotor abilities involved in balance control, they also increase the risk of injuries. The influence on postural control of lower limb trauma induced by judo practice was examined in healthy and previously injured judoists (PIJ). During static and dynamic tests, performed with or without vision, PIJ achieved the best performances in maintaining proper balance, except for those with the most severe antecedents of trauma. The severity of the pathology appeared to be the most important parameter prejudicial to balance control while the location, frequency and diversity of trauma had only a modest impact. This shows that PIJ develop excellent sensory and cognitive adaptation abilities to constraints involving new patterns of compensation and of body scheme.


Assuntos
Traumatismos em Atletas/fisiopatologia , Traumatismos da Perna/fisiopatologia , Artes Marciais/lesões , Equilíbrio Postural/fisiologia , Postura/fisiologia , Adaptação Fisiológica , Adolescente , Adulto , Análise de Variância , Distribuição de Qui-Quadrado , Humanos , Masculino , Propriocepção
17.
Environ Health Perspect ; 107 Suppl 2: 245-52, 1999 May.
Artigo em Inglês | MEDLINE | ID: mdl-10350507

RESUMO

This article is a description of the current situation in France with regard to occupational cancer: research, prevention, and occupation. Toxicologic experiments are carried out using (italic)in vitro(/italic) and (italic)in vivo(/italic) tests, particularly using transgenic mice. Several epidemiologic studies have been conducted over the last decades: population-based case-control studies; mortality studies and cancer incidence studies carried out in historical cohorts of workers employed in the industry; and case-control studies nested in occupational cohorts. French ethical aspects of toxicologic and epidemiologic studies are described. The results thus obtained are used to establish regulations for the prevention and the compensation of cancers attributable to occupational exposure. This French regulation for prevention of occupational cancer involves several partners: (italic)a(/italic)) the states authorities, including labor inspectors, responsible for preparing and implementing the labor legislation and for supervising its application, particularly in the fields of occupational health and safety and working conditions; (italic)b(/italic)) the Social Security Organisation for the analysis of present or potential occupational risks based on tests, visits in plants, complaints or requests from various sources, and statistics. These activities are performed within the framework of the general French policy for the prevention of occupational cancer. This organization includes the National Institute for Research and Safety, particularly involved in research in the various fields of occupational risks--animal toxicology, biologic monitoring, exposure measurements epidemiology, psychology, ergonomy, electronic systems and machineries, exposure to chemicals, noise, heat, vibration, and lighting; and (italic)c(/italic)) companies where the regulation defines the role of the plant manager, the occupational physician, and the Health, Safety and Working Conditions Committee (comprising the manager, employees' representatives, the occupational physician, and the safety department) in dealing with any problem regarding safety, occupational hygiene, and working conditions. These organizations along with medical practitioners are involved with the compensation of occupational cancers. The regulation for compensation includes the tables of occupational cancer, the possibility of recognition of a cancer case when the requirements of the tables are not met, and the postprofessional follow-up of workers exposed to a carcinogenic agent.


Assuntos
Neoplasias/epidemiologia , Neoplasias/prevenção & controle , Doenças Profissionais/epidemiologia , Doenças Profissionais/prevenção & controle , Saúde Ocupacional , Indenização aos Trabalhadores , Animais , Estudos de Casos e Controles , Estudos de Coortes , Modelos Animais de Doenças , Projetos de Pesquisa Epidemiológica , França/epidemiologia , Humanos , Incidência , Concentração Máxima Permitida , Camundongos , Neoplasias/economia , Neoplasias/etiologia , Doenças Profissionais/economia , Doenças Profissionais/etiologia , Saúde Ocupacional/legislação & jurisprudência , Medicina do Trabalho/organização & administração , Papel do Médico , Vigilância da População , Indenização aos Trabalhadores/organização & administração
18.
Occup Environ Med ; 55(8): 533-40, 1998 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-9849540

RESUMO

OBJECTIVES: To better understand the relations between occupational exposure, blood antioxidant enzyme activities, total plasma antioxidant concentration, and the severity of coal workers' pneumoconiosis (CWP). METHODS: Blood samples were obtained from miners without CWP exposed to low dust concentrations for > or = 4 years at the time of the study (n = 105), or exposed to high dust concentrations for > or = 14 years at the time of the study (n = 58), and from retired miners with CWP (n = 19). Miners without CWP were classified into three subgroups according to their estimated cumulative exposure to dust. Chest x ray films were obtained for each miner. Miners were classified in five subgroups according to their International Labour Organisation (ILO) profusion grades. Univariate tests were completed by multiple linear regression analyses. RESULTS: The estimated cumulative exposure to dust was strongly positively related to erythrocyte catalase activity and strongly negatively related to Cu++/Zn++ SOD activity only in miners exposed to high dust concentrations for > or = 14 years at the time of the study (F tests p = 0.006 and p = 0.004 respectively). Moreover, catalase activity was strongly related to the severity of CWP expressed as five subgroups of ILO profusion grades (F test p = 0.003); the greatest difference in the mean values was found between the group of 1/1 to 1/2 ILO profusion grades and the group of 2/1 to 3/3 ILO profusion grades. CONCLUSION: These results are in good agreement with the hypothesis that production of reactive oxygen species may be an important event in the exposure to coal mine dusts and the severity of CWP. Erythrocyte catalase and Cu++/Zn++ SOD activities are more closely related to recent exposure to high dust concentrations than to cumulative exposure, and could be considered as biological markers of exposure rather than as markers of early adverse biological effect.


Assuntos
Catalase/sangue , Minas de Carvão , Exposição Ocupacional/efeitos adversos , Pneumoconiose/enzimologia , Superóxido Dismutase/sangue , Adulto , Antioxidantes/análise , Biomarcadores/sangue , Eritrócitos/enzimologia , Glutationa Peroxidase/sangue , Humanos , Masculino , Pessoa de Meia-Idade , Pneumoconiose/sangue , Pneumoconiose/diagnóstico por imagem , Tomografia Computadorizada por Raios X
19.
Rev Esp Cardiol ; 51(8): 655-60, 1998 Aug.
Artigo em Espanhol | MEDLINE | ID: mdl-9780780

RESUMO

INTRODUCTION AND OBJECTIVES: The minimum value of dP/dT is a parameter of diastolic function that can be estimated noninvasively by analyzing the profile of velocity of the mitral regurgitant jet, recorded by continuous-wave Doppler. This estimation requires a complex analysis of the curves that impedes its practical use. Our objective was to validate a simplified method to estimate noninvasively the value of dP/dTmin when mitral regurgitation exists. We calculated the pendient of the profile of velocity of the curve of mitral regurgitation during its deceleration, between 3 and 1.5 m/s, an interval that defines a difference in pressure using the formula delta p = (4v2(1) - 4v2(2)). We divided this interval by the time needed by the jet to decelerate from 3 to 1.5 m/s, obtaining the rate of pressure decay, in mmHg/s. METHODS: We provoked mitral regurgitation in five pigs and registered dP/dT and the curve velocity of mitral regurgitation simultaneously, by micromanometer-tipped catheter and continuous-wave Doppler, respectively. The rate of pressure decay was calculated on the mitral regurgitation curve. RESULTS: We obtained 29 simultaneous registers. The coefficient for the correlationship between dP/dT and the rate of pressure decay was with an r value of 0.62 (p < 0.0001). The rate of pressure decay underestimated systematically the value of dP/dT. Intra and interobserver variability of TDP was 9 and 11%, respectively. CONCLUSIONS: This study validates a simplified method to estimate dP/dT noninvasively, with acceptable correlation with invasive measurements and adequate reproducibility.


Assuntos
Ecocardiografia Doppler , Insuficiência da Valva Mitral/fisiopatologia , Função Ventricular/fisiologia , Animais , Interpretação Estatística de Dados , Diástole , Variações Dependentes do Observador , Reprodutibilidade dos Testes , Suínos , Pressão Ventricular/fisiologia
20.
Sante Publique ; 10(2): 177-90, 1998 Jun.
Artigo em Francês | MEDLINE | ID: mdl-9774916

RESUMO

The prevalence of sleep-disordered breathing (SDB) was evaluated in a male population sample of Lorraine (university staff), with a protocol including a self-completed standardized questionnaire, anthropometry (including neck, waist and hip circumferences) and non-invasive ear, nose, and throat examination. Among 357 subjects present in the institution at the moment of the survey, 334 (93.6%) accepted to participate, and 300 (84%) returned the questionnaires. The anthropometric results corresponded to the French normative values according to gender and age. We chose a value of 32 as limit of the body mass index (BMI) between weight excess and obesity; this limit was exceeded by 7.2% of the subjects. The mean age of the sample was 44.8 (SD 10.1) years; the waist-to-hip ratio was of 0.907 +/- 0.053. The ENT examination found a high prevalence of nasal septum deviations (52.6%), of soft palate (25.2%), and uvula (42%) abnormalities; 32.1% of the subjects had experienced amygdalectomy. The non-responses to the questionnaire were infrequent (less than 2%), except for the questions regarding a history of hypertension (2.6%), weight fluctuations the last 5 years (7.6%), and the number of years in school (12%). The questionnaire included, for each question, the optional answer "don't know"; this answer was chosen for the questions concerning the duration of snoring (37.1%), stopping breathing during sleep (12.7%) and the parental history of narcolepsy (18.7 and 20.7%) and sleep apnoea (33.7 and 36.4%). 5.7% of the subjects declared sleep apnoeas at least once per week: 16.1% had unrefreshing sleep; 10.6% admitted to excessive daytime sleepiness; 41.9% were habitual snorers. These results indicate a prevalence of SDB in our sample which is comparable to the figures obtained in other European studies. Further analysis of our data will indicate if, besides weight excess and its troncular distribution, cigarette smoking and respiratory symptoms, the "minor" ENT abnormalities play a role in the pathogenesis of SDB.


Assuntos
Síndromes da Apneia do Sono/epidemiologia , Adulto , Constituição Corporal , Estatura , Índice de Massa Corporal , Peso Corporal , França/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Narcolepsia/epidemiologia , Septo Nasal/patologia , Pescoço/anatomia & histologia , Doenças Nasais/epidemiologia , Obesidade/epidemiologia , Palato Mole/anormalidades , Prevalência , Fases do Sono , Fumar/epidemiologia , Ronco/epidemiologia , Inquéritos e Questionários , Tonsilectomia/estatística & dados numéricos , Saúde da População Urbana/estatística & dados numéricos , Úvula/anormalidades
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