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Res Vet Sci ; 75(1): 43-53, 2003 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-12801462

RESUMO

Pathological findings of four cats with severe and diffuse smooth muscle hypertrophy of the small intestine (MHSI) are reported and compared to those of five cats with segmental MHSI secondary to neoplastic obstruction and four controls. Histology demonstrated a constant association between idiopathic MHSI and submucosal fibrosis and chronic lymphoplasmacytic enteritis. Morphometry (gut diameter, thickness and area of muscular layers, number and density of smooth muscle nuclei) and MIB-1-immunolabelling showed that the thickness increase was mostly due to hypertrophy, but hyperplasia was also evident. Microbiology from ileal content samples was performed in two cats with primary MHSI, and Campylobacter spp. were isolated, which were also demonstrated by immunohistochemistry and ultrastructure. The association of chronic enteritis with idiopathic MHSI suggests that factors released in intestinal inflammation may also act as hypertrophy stimuli for smooth muscle cells.


Assuntos
Doenças do Gato/patologia , Intestino Delgado/patologia , Animais , Gatos , Feminino , Hipertrofia/patologia , Hipertrofia/veterinária , Imuno-Histoquímica/veterinária , Mucosa Intestinal/patologia , Mucosa Intestinal/ultraestrutura , Intestino Delgado/ultraestrutura , Masculino , Microscopia Eletrônica/veterinária , Músculo Liso/patologia , Músculo Liso/ultraestrutura
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