A new simpler image quality index based on body size for FDG-PET/CT.

Noise equivalent count density (NEC density ) is often used to evaluate the image quality of whole-body fluorodeoxyglucose tomography tests. However, this index is calculated using the patient volume, which is difficult to obtain at every facility. In this study, we proposed new image quality indices that can be evaluated at all facilities. In total, 94 patients were enrolled in the study. The correlations of patients' body weight and BMI with volume were examined. New image quality indices normalized by body weight and BMI were defined as NEC bw and NEC bmi , respectively. Correlations between NEC bw , NEC bmi , and NEC density were examined. Further, the correlations between these two new indices and visual scores were evaluated. Good correlations were observed between volume and body weight (r = 0.861, P  < 0.001) and between volume and BMI (r = 0.728, P  < 0.001). NEC bw and NEC bmi correlated well with NEC density (r = 0.954 for NEC bw and r = 0.897 for NEC bmi , P  < 0.001). These correlations improved when the examined bed positions were set to the same number. Additionally, the correlations of visual scores with NEC bw and NEC bmi were similar to those between the visual score and NEC density . Our investigation indicated that the newly proposed image quality metrics, NEC bw and NEC bmi , were easily calculated and as useful as NEC density for evaluating image quality when subjects had similar physiques.

Comprehensive evaluations of a prototype full field-of-view photon counting CT system through phantom studies.

Objective. Photon counting CT (PCCT) has been a research focus in the last two decades. Recent studies and advancements have demonstrated that systems using semiconductor-based photon counting detectors (PCDs) have the potential to provide better contrast, noise and spatial resolution performance compared to conventional scintillator-based systems. With multi-energy threshold detection, PCD can simultaneously provide the photon energy measurement and enable material decomposition for spectral imaging. In this work, we report a performance evaluation of our first CdZnTe-based prototype full-size PCCT system through various phantom imaging studies.Approach.This prototype system supports a 500 mm scan field-of-view and 10 mmz-coverage at isocenter. Phantom scans were acquired using 120 kVp from 50 to 400 mAs to assess the imaging performance on: CT number accuracy, uniformity, noise, spatial resolution, material differentiation and quantification.Main results.Both qualitative and quantitative evaluations show that PCCT, under the tested conditions, has superior imaging performance with lower noise and improved spatial resolution compared to conventional energy integrating detector (EID)-CT. Using projection domain material decomposition approach with multiple energy bin measurements, PCCT virtual monoenergetic images have lower noise, and good accuracy in quantifying iodine and calcium concentrations. These results lead to increased contrast-to-noise ratio (CNR) for both high and low contrast study objects compared to EID-CT at matched dose and spatial resolution. PCCT can also generate super-high resolution images using much smaller detector pixel size than EID-CT and greatly improve image spatial resolution.Significance.Improved spatial resolution and quantification accuracy with reduced image noise of the PCCT images can potentially lead to better diagnosis at reduced radiation dose compared to conventional EID-CT. Increased CNR achieved by PCCT suggests potential reduction in iodine contrast media load, resulting in better patient safety and reduced cost.

[Scientific Research Group Report: Nationwide Survey on Radiation Exposure of Pediatric CT Examination in Japan (2018)].

PURPOSE: To understand the latest pediatric computed tomography (CT) exposure required for the revision of national DRLs. METHODS: A questionnaire was sent to 409 facilities where the members of the Japanese Society of Radiological Technology and the Japanese Society of Pediatric Radiology are enrolled. We investigated the imaging conditions, CTDIvol, and DLP of the pediatric head, chest, and abdominal CT examinations. RESULTS: In all, 43 facilities (11%) responded to our survey. multi detector-row CT (MDCT) systems were available in all surveyed facilities. More than 98% of the MDCT systems had more than 64 detector rows. The CTDIvol of all CT protocols was lower than the NDRL due to the progress of updating to MDCTs with radiation exposure reduction functions such as an iterative reconstruction, but the DLP of head and abdominal CT protocols of some age group were higher than NDRL. CONCLUSION: It is necessary to review the imaging protocol with the attending physician and radiologist and consider further optimization of medical exposure.

Evaluation of Apparent Noise on CT Images Using Moving Average Filters.

This study aims to devise a simple method for evaluating the magnitude of texture noise (apparent noise) observed on computed tomography (CT) images scanned at a low radiation dose and reconstructed using iterative reconstruction (IR) and deep learning reconstruction (DLR) algorithms, and to evaluate the apparent noise in CT images reconstructed using the filtered back projection (FBP), IR, and two types of DLR (AiCE Body and AiCE Body Sharp) algorithms. We set a square region of interest (ROI) on CT images of standard- and obese-sized low-contrast phantoms, slid different-sized moving average filters in the ROI vertically and horizontally in steps of 1 pixel, and calculated the standard deviation (SD) of the mean CT values for each filter size. The SD of the mean CT values was fitted with a curve inversely proportional to the filter size, and an apparent noise index was determined from the curve-fitting formula. The apparent noise index of AiCE Body Sharp images for a given mAs value was approximately 58, 23, and 18% lower than that of the FBP, AIDR 3D, and AiCE Body images, respectively. The apparent noise index was considered to reflect noise power spectrum values at lower spatial frequency. Moreover, the apparent noise index was inversely proportional to the square roots of the mAs values. Thus, the apparent noise index could be a useful indicator to quantify and compare texture noise on CT images obtained with different scan parameters and reconstruction algorithms.

PATIENT-SPECIFIC ORGAN DOSE EVALUATION BASED ON MONTE CARLO SIMULATION AND DOSE METRICS IN PAEDIATRIC CHEST-ABDOMEN-PELVIS CT EXAMINATIONS.

This study aimed to determine organ doses based on Monte Carlo (MC) simulations for individual paediatric patients undergoing chest-abdomen-pelvis computed tomography (CT) examinations and to evaluate correlations of organ doses with dose metrics. MC simulations were performed by inputting detailed descriptions of a CT scanner, scanning parameters and CT images of 51 paediatric patients aged from 0 to 10 years into the simulation software. Organ doses for six radiosensitive organs were determined from dose distribution images obtained as the simulation results. The correlations of organ doses with dose metrics such as volume CT dose index, size-specific dose estimates (SSDEs), and organ-specific SSDEs were evaluated from the corresponding coefficients of determination. Organ doses for ages of 0-1 and 1-5 years were 22%-32% lower than those for ages of 5-10 years. Organ doses exhibited higher linear correlations with SSDEs and organ-specific SSDEs, and can be easily estimated using the linear regression.

Optimization of injection dose in 18F-FDG PET/CT based on the 2020 national diagnostic reference levels for nuclear medicine in Japan.

OBJECTIVE: Recently, the national diagnostic reference levels (DRLs) in Japan were revised as the DRLs 2020, wherein the body weight-based injection dose optimization in positron emission tomography/computed tomography using 18F-fluoro-2-deoxy-D-glucose (18F-FDG PET/CT) was first proposed. We retrospectively investigated the usefulness of this optimization method in improving image quality and reducing radiation dose. METHODS: A total of 1,231 patients were enrolled in this study. A fixed injection dose of 240 MBq was administered to 624 patients, and a dose adjusted to 3.7 MBq/kg body weight was given to 607 patients. The patients with body weight-based injection doses were further divided according to body weight: group 1 (≤ 49 kg), group 2 (50-59 kg), group 3 (60-69 kg), and group 4 (≥ 70 kg). The effective radiation dose of FDG PET was calculated using the conversion factor of 0.019 mSv/MBq, per the International Commission on Radiological Protection publication 106. Image quality was assessed using noise equivalent count density (NECdensity), which was calculated by excluding the counts of the brain and bladder. The usefulness of the injection dose optimization in terms of radiation dose and image quality was analyzed. RESULTS: The body weight-based injection dose optimization significantly decreased the effective dose by 11%, from 4.54 ± 0.1 mSv to 4.05 ± 0.8 mSv (p < 0.001). Image quality evaluated by NECdensity was also significantly improved by 10%, from 0.39 ± 0.1 to 0.43 ± 0.2 (p < 0.001). In no case did NECdensity deteriorate when the effective dose was decreased. In group 1, the dose decreased by 32%, while there was no significant deterioration in NECdensity (p = 0.054). In group 2, the dose decreased by 17%, and the NECdensity increased significantly (p < 0.01). In group 3, the dose decreased by 3%, and the NECdensity increased significantly (p < 0.01). In group 4, the dose increased by 14%, but there was no significant change in the NECdensity (p = 0.766). CONCLUSION: Body weight-based FDG injection dose optimization contributed to not only the reduction of effective dose but also the improvement of image quality in patients weighing between 50 and 69 kg.

Radiation Dose Reduction for Computed Tomography Localizer Radiography Using an Ag Additional Filter.

OBJECTIVE: This study aimed to assess the potential of an Ag additional filter attached to the bow tie filter of a computed tomography (CT) scanner to reduce the radiation dose in CT localizer radiography. METHODS: Radiation doses in CT localizer radiography with Cu and Ag additional filters were evaluated based on dose measurements and Monte Carlo simulations. Image quality evaluations of an adult torso phantom were performed, and the automatic exposure control performance was evaluated in terms of the water-equivalent thickness estimated from CT localizer radiographs. RESULTS: With the Ag additional filter, effective doses were approximately 72% to 75% lower than those with the Cu additional filter. The image quality and water-equivalent thickness with the Ag additional filter were similar to those with the Cu additional filter. CONCLUSIONS: The Ag additional filter helped significantly reduce radiation doses in CT localizer radiography while maintaining image quality and performance.

Correlation analysis of organ doses determined by Monte Carlo simulation with dose metrics for patients undergoing chest-abdomen-pelvis CT examinations.

OBJECTIVES: This study aimed to determine organ doses based on Monte Carlo (MC) simulations for individual patients undergoing routine adult chest abdomen-pelvis computed tomography (CT) examinations and to evaluate the correlations of organ doses with patient size and dose metrics. METHODS: MC simulations were performed by reading detailed descriptions of the CT scanner, scanning parameters, and CT images of phantoms and patients into the simulation software. The simulation models were validated by comparing the simulated doses with the doses measured by in-phantom dosimetry using radiophotoluminescent glass dosimeters and an adult anthropomorphic phantom, and organ doses for 80 patients were determined from the simulation results. To obtain patient size and dose metrics, body mass index and volume computed tomography dose index (CTDIvol) data were collected. Water equivalent diameter (WED) was calculated from the CT images of each patient. Size-specific dose estimates (SSDE) were calculated using CTDIvol and average WED over the scan range, and organ specific SSDE were calculated using the average CTDIvol and WED over each organ position. The correlations of organ doses with dose metrics were evaluated using coefficients of determination. RESULTS: Organ doses increased with patient size, and the doses for obese were approximately two to three times higher than those for underweight patients. Organ doses exhibited stronger linear relationships with organ specific SSDE (R2 ≥ 0.82) than other dose metrics. CONCLUSIONS: The linear regression fits between organ doses determined by MC simulation and organ-specific SSDE are valuable for simplified and accurate organ dose estimation for individual patients undergoing CT examinations.

[Survey of Recognition, Utilization, and Evaluation for Diagnostic Reference Levels in the Field of X-ray Computed Tomography].

A survey on recognition, utilization, and evaluation for diagnostic reference levels (DRLs) after establishing Japan DRLs 2015 in the field of X-ray computed tomography (CT) was conducted for members of Japanese Society of Radiological Technology using web-based questionnaire system. The survey consisted of provincial branches to which respondents belong, their occupation, years of professional experience, years of experience in X-ray CT section, recognition of DRLs, and utilization and evaluation of DRLs in the field of X-ray CT section. Each survey item had one to eight questions. A total of 369 members completed the questionnaire. Among them, 295 out of 369 (79.9%) members knew that DRLs were released in Japan. After establishing the DRLs, 226 of 330 (68.5%) and 123 of 319 (38.6%) members investigated the doses used for adult and pediatric CT at their facilities, respectively. Although 345 of 369 (93.5%) members answered that DRLs are necessary for the field of X-ray CT, only 142 of 369 (38.5%) members thought that the established DRLs are enough to use in the field of X-ray CT. The survey has clarified the current status of recognition, utilization, and evaluation for DRLs in the field of X-ray CT after establishing the DRLs in Japan.

USEFULNESS OF SIZE-SPECIFIC DOSE ESTIMATES IN PEDIATRIC COMPUTED TOMOGRAPHY: REVALIDATION OF LARGE-SCALE PEDIATRIC CT DOSE SURVEY DATA IN JAPAN.

The objective of this research is to calculate the organ equivalent dose and effective dose from the scanning conditions at 165 centers in Japan using computed tomography (CT) Dose software and compare the results with the CT dose index volume (CTDIvol), dose length product (DLP) and size-specific dose estimates (SSDE) to validate the usefulness of SSDE. The CTDIvol and DLP were significantly lower in infants than in children (p < 0.05). No significant differences were found in the bone marrow equivalent dose and effective dose for the torso between infants and children (p > 0.05), and the bone marrow equivalent dose and effective dose for the head were higher in infants than children (p < 0.05). No significant difference was found in SSDE for the torso between infants and children (p > 0.05). Organ equivalent and effective doses for head CT scans are higher in infants than in children (I/P ratio ≥ 1). The I/P ratios of CTDIvol and DLP for chest and abdominal CT scans are also higher in Japan than in other countries. CTDIvol and DLP are not accurate when used as a dose index, and SSDE was considered suitable for dose assessment of the torso. However, for head CT in infants, a further reduction in radiation exposure is required.

Investigation of the Section Thickness Measurement in Tomosynthesis by Thin Metal Plate Edge Method.

When performing tomosynthesis, the section thickness needs to be set depending on a radiographic part and its diagnostic purpose. However, the section thickness in tomosynthesis has not been clearly defined and its measurement method has not been established yet. In this study, we devised the alternative measurement method to diagnose the section thickness using an edge of thin metal plate, and compared with the simulation results, the wire and bead method reported in the previous papers. The tomographic image of the thin metal plate positioned on the table top inclining 30 degrees, which showed the edge spread function (ESF) of each tomographic height, was taken, and then the line spread function (LSF) was obtained by differentiating the ESF image. For the next, a profile curve was plotted by maximum values of LSF of each tomographic height, and a section thickness was calculated using the full width at half maximum (FWHM) of the profile curve. The edge method derived the section thickness close to the simulation results than the other methods. Further, the section thickness depends on the thickness of the metal plate and not the material. The thickness of the metal plate suitable for the evaluation of section thickness is 0.3 mm that is equivalent to pixel size of the flat panel detector (FPD). We conducted quantitative verification to establish the measurement method of the section thickness. The edge method is a useful technique as well as the wire and bead method for grasping basic characteristics of an imaging system.

A simulation study for estimating scatter fraction in whole-body 18F-FDG PET/CT.

Whereas Monte Carlo (MC) simulation is widely utilized in estimation of the scatter component, a simulation model which can calculate the scatter fraction (SF) of each patient is needed for making an accurate image quality assessment for clinical PET images based on the noise equivalent count. In this study, an MC simulation model was constructed which can calculate the SF for various phantoms. We utilized the Geant4 toolkit based on MC simulation to make a model of a PET scanner with a scatter phantom, and SFs calculated with this model were compared with the SF (SFconstant: 44%) measured with use of an actual PET scanner. Additionally, the SF values for an anthropomorphic phantom were calculated from its voxel phantom. Furthermore, we evaluated the impact on the SF due to the difference in the source distribution inside the phantom. The SF calculated from the scatter phantom in the MC simulation was 44%, the same as the SFconstant value. The average SF for the anthropomorphic phantom was 41%, but there was a maximum of 14 percentage points difference between each scan range, and the maximum difference in the SF was 8 percentage points for the difference in the source distribution. We constructed an MC simulation model which can calculate SFs for various phantoms. The SF was confirmed to be affected significantly by the source distribution. We judged that the actually measured SFconstant obtained from the PET scanner with the scatter phantom was not suitable for the assessment of the quality of all patient images.

Nationwide survey of radiation exposure during pediatric computed tomography examinations and proposal of age-based diagnostic reference levels for Japan.

BACKGROUND: Diagnostic reference levels (DRLs) have not been established in Japan. OBJECTIVE: To propose DRLs for CT of the head, chest and abdomen for three pediatric age groups. MATERIALS AND METHODS: We sent a nationwide questionnaire by post to 339 facilities. Questions focused on pediatric CT technology, exposure parameters, CT protocols, and radiation doses for age groups <1 year, 1-5 years, and 6-10 years. RESULTS: For the three age groups in the 196 facilities that responded, the 75th percentile values of volume CT dose index based on a 16-cm phantom (CTDIvol 16 [mGy]) for head, chest and abdominal CT were for infants 39.1, 11.1 and 12.0, respectively; for 1-to 5-year-olds 46.9, 14.3 and 16.7, respectively; and for 6-to 10-year-olds 67.7, 15.0 and 17.0, respectively. The corresponding dose­length products (DLP 16 [mGy・cm]) for head, chest and abdominal CT were for infants 526.1, 209.1 and 261.5, respectively; for 1-to 5-year-olds 665.5, 296.0 and 430.8, respectively; and for 6-to 10-year-olds 847.9, 413.0 and 532.2, respectively. CONCLUSION: The majority of CTDIvol 16 and DLP 16 values for the head were higher than DRLs reported from other countries. For risk reduction, it is necessary to establish DRLs for pediatric CT in Japan.

Ultra-High-Resolution Computed Tomography of the Lung: Image Quality of a Prototype Scanner.

PURPOSE: The image noise and image quality of a prototype ultra-high-resolution computed tomography (U-HRCT) scanner was evaluated and compared with those of conventional high-resolution CT (C-HRCT) scanners. MATERIALS AND METHODS: This study was approved by the institutional review board. A U-HRCT scanner prototype with 0.25 mm x 4 rows and operating at 120 mAs was used. The C-HRCT images were obtained using a 0.5 mm x 16 or 0.5 mm x 64 detector-row CT scanner operating at 150 mAs. Images from both scanners were reconstructed at 0.1-mm intervals; the slice thickness was 0.25 mm for the U-HRCT scanner and 0.5 mm for the C-HRCT scanners. For both scanners, the display field of view was 80 mm. The image noise of each scanner was evaluated using a phantom. U-HRCT and C-HRCT images of 53 images selected from 37 lung nodules were then observed and graded using a 5-point score by 10 board-certified thoracic radiologists. The images were presented to the observers randomly and in a blinded manner. RESULTS: The image noise for U-HRCT (100.87 ± 0.51 Hounsfield units [HU]) was greater than that for C-HRCT (40.41 ± 0.52 HU; P < .0001). The image quality of U-HRCT was graded as superior to that of C-HRCT (P < .0001) for all of the following parameters that were examined: margins of subsolid and solid nodules, edges of solid components and pulmonary vessels in subsolid nodules, air bronchograms, pleural indentations, margins of pulmonary vessels, edges of bronchi, and interlobar fissures. CONCLUSION: Despite a larger image noise, the prototype U-HRCT scanner had a significantly better image quality than the C-HRCT scanners.

[Summary of a survey on radiation exposure during pediatric computed tomography examinations in Japan, focusing on the computed tomography examination environment].

We carried out a nationwide questionnaire survey of pediatric computed tomography (CT) in 339 facilities. Most facilities operated multi detector-row CT (MDCT), and over half operated 64, 128, 256 and 320-slice MDCT. In 32% of facilities, pediatric CT protocols were set taking image quality and dose into consideration. However, in the other facilities, pediatric CT protocols may not be optimized because there is no clear standard for image quality or dosage for pediatric CT examinations in Japan. To promote the optimization of pediatric CT protocols, we regard it as an urgent task to establish diagnostic reference levels for pediatric CT examinations.