[Investigation of peroxide modification of low- and very low-density lipoproteins in patients with coronary heart disease by the method of fluorescent spectroscopy].

In the total fraction of low and very low density lipoproteins (LDL+VLDL) isolated from serum by precipitation in the presence of heparin-Mn the copper-induced lipid peroxidation was accompanied by accumulation of LPO products, a decrease ANS fluorescence intensity (F(ANS)) and an increase in probe--cation DSP-6, a fluorescence intensity decrease of intrinsic in the ultraviolet area (F(uv)) and an increase in the visible area (F(vis)). The degree of lipoprotein modification was estimated by calculating the F(vis)/F(uv) and F(DSP)-6/F(ANS) ratio. Strong positive correlation was found between these ratios and concentration of thiobarbituric acid-reactive substances (TBARS) of LDL+VLDL samples isolated from sera of 49 donors and incubated at 37 degrees C in the presence of 50 M CuSO4 during 0, 3 and 24 hr (F(vis)/F(uv) (r = 0.75; p < 0.001) and F(DSP-6)/F(ANS) (r = 0.73; p < 0.001)). Very strong positive correlation was also found between both fluorescent parameters F(vis)/F(uv) and F(DSP-6)/F(ANS) (r = 0.95, p < 0.001). Changes in the values of F(vis)/ F(uv), F(DSP-6)/F(ANS), concentration of TBARS in 75 patients with documented coronary heart disease (CHD) and 49 apparently healthy donors were studied. No significant differences of these parameters in LDL+VLDL of patients with CHD and donors were found.

[Analysis of the amount of plasma cholesterol and triglycerides in patients with coronary heart disease].

Fluorescence technique was used to study the time course of changes in the amount of blood cholesterol and triglycerides (C+TG) in 43 patients with Q- and non-Q-wave myocardial infarction (MI) on days 1, 2, 3, and 10 of the disease, in 82 patients with chronic coronary heart disease (CHD), and in 43 apparently healthy donors. Within the first 3 days of the disease, the level of C+TG in the patients with acute MI (AMI) was significantly lower than that in the patients with chronic CHD and in the donors. By day 10 of their hospital stay, the level of lipids in patients with AMI increased and reached the levels observed in the control group.

[Characteristics of rehabilitation of physical work capacity in patients with prior myocardial infarct depending on baseline tolerance of exercise test]. / Osobennosti vosstanovleniia fizicheskoi rabotosposobnosti u bol'nykh, perenesshikh infarkt miokarda, v zavisimosti ot iskhodnoi tolerantnosti k fizicheskoi nagruzke.

The restorative features of physical working capacity (PWC) in relation to baseline exercise (E) tolerance were examined in 223 males aged 30-58 years who had sustained large myocardial infarction. The results indicated that there was a positive dynamics of PWC parameters in the patients who had an initial threshold exercise intensity (TEI) of 25-50 W, the greatest increase in these parameters occurring within three months of the disease. The patients who had a TEI of 75 W or more virtually showed unaltered PWC during a 12-month follow-up. This fact is suggestive of earlier restoration of residual PWC in the patients at a TEI of 75 W or greater. An increase in heart rate (HR), double product (DP), cardiac index (CI) in response to higher exercise was much more significant with higher E. At the same time when the patients performed a routine 25-W exercise during 5 min, the rise in HR, DP, and CI was low, whereas the patients having a lower tolerance to routine E, increased HR, DP, and CI.

[Possibility of correcting atherogenic dyslipoproteinemia by the mountain climate treatment]. / Issledovanie vozmozhnosti korrektsii aterogennykh dislipoproteinemii gornoklimaticheskim lecheniem.

Whether dyslipoproteinemias can be corrected with 24-day mountain therapy in a mid-mountainous area (the village of Malinovka, 1600 m above the sea-level) was studied in 225 males who had sustained large myocardial infarction. The posthospital rehabilitation of postinfarction patients in a mid-mountainous sanatorium caused a substantial change in blood lipoprotein composition, which were generally antiatherogenic. The antiatherogenic changes in blood lipoprotein composition retained within 10 months after their stay at the sanatorium, which indicates that mid-mountain climate is a promising tool for non-drug prevention and correction of atherogenic dyslipoproteinemias.

[The effect of climatic treatment in the central highlands on the lipid, cortisol, renin and aldosterone content of the blood in patients with an acute myocardial infarct]. / Vliianie klimaticheskogo lecheniia v usloviiakh srednegor'ia na soderzhanie lipidov, kortizola, renina i aldosterona krovi u bol'nykh ostrym infarktom miokarda.

124 capable men who had survived large focal myocardial infarction underwent a 24-day course of treatment in a cardiological sanatorium situated in climatic conditions of low mountains (1600 m above the sea level). It was found that posthospital rehabilitation under conditions of low-mountain climate promoted antiatherogenic shifts in blood lipoproteins composition most distinct in patients with hyperlipidemias. Hydrocortisone and renin levels returned to normal values, physical performance rose. These positive trends make nonpharmacological rehabilitation and secondary prevention of coronary heart disease in low-mountain climate promising.

[The initial results of the sanatorium rehabilitation of patients having had an acute myocardial infarct in a mid-alpine climate]. / Pervye itogi sanatornoi reabilitatsii bol'nykh, perenesshikh ostryi infarkt miokarda, v usloviiakh srednegornogo klimata.

Short-term results of rehabilitation of 1046 CHD patients at a cardiological sanatorium in mountains at average altitude (1600 m above the sea level) were studied. Large focal myocardial infarction (MI) was found in 738 of them, small focal MI in 249, and acute focal myocardial dystrophy of ischemic genesis in 59. Of 1046 patients considerable improvement of the status after rehabilitation therapy at the sanatorium was noted in 27.6%, improvement in 64.5%, no changes in 6.1%, deterioration in 1.7%; one patient died. This type of therapy in a mountainous climate at average altitude yielded good immediate results in most of the patients (92.06%) with MI and could be recommended for rehabilitation of CHD patients at the 2nd stage of treatment at a sanatorium.

Prevalence and clinical peculiarities of essential hypertension in a population living at high altitude.

Screening examinations were performed in ethnically related populations of men aged 30-59 years, living in high mountain regions of Tien-Shan and Pamir (2800-3600 m above sea level) and in the lowlands (800-900 m). The incidence of borderline hypertension (BH) and essential hypertension (EH) was statistically significantly higher among the inhabitants of lowland regions: EH was recorded among them in 15.4%, vs. 4.2% among men living at high altitude; BH was present among the male lowland population (LL) in 10.6% vs. 6.0% among highlanders (HL). The main characteristic clinico-functional feature of EH in HL was its frequent association with high-altitude pulmonary hypertension and right ventricular hypertrophy. Aldosterone excretion was in HL with EH substantially lower, and sodium excretion higher, than in a comparable group of lowland inhabitants.

[Clinical and instrumental characteristics of primary high altitude arterial pulmonary hypertension]. / Kliniko-instrumental'naia kharakteristika pervichnoi vysokogornoi arterial'noi legochnoi gipertonii

The clinical pattern of primary high altitude pulmonary arterial hypertension observed in permanent residents of mountain regions is described. The diagnostic value of some non-invasive instrumental methods in primary high altitude pulmonary artery hypertension is analysed: electro- and vectorcardiography, rheopulmonography, and indirect pulmonary artery pressure determination. It is suggested to distinguish the labile, stable and decompensated forms of the disease on the basis of its clinical and functional peculiarities. The criterion for the initial two forms consists in the persistence of the pulmonary artery pressure elevation, while the latter form is established when the high altitude cor pulmonale gets decompensated. Functional vasoconstriction of the pulmonary resistive vessels was shown to play an important role in the genesis of the disease: the administration of 0.5 mg of nitroglycerine and a 5-minute oxygen inhalation caused a positive dynamics in the indices of the pulmonary rheogramme and a reduction of the pulmonary artery pressure, which did not reach the level of the plane inhabitants, though.