RESUMO
Lower urinary tract function was studied in patients with Parkinson's disease. A significant proportion of patients receiving levodopa manifested clinical and radiological evidence of bladder outlet obstruction. We believe that neuropharmacologic bladder neck obstruction may be caused by the alpha-adrenergic properties of the metabolites of levodopa.
Assuntos
Levodopa/efeitos adversos , Doença de Parkinson/complicações , Obstrução do Colo da Bexiga Urinária/induzido quimicamente , Ácido 3,4-Di-Hidroxifenilacético/farmacologia , Idoso , Dopamina/farmacologia , Feminino , Ácido Homovanílico/farmacologia , Humanos , Masculino , Pessoa de Meia-Idade , Doença de Parkinson/tratamento farmacológico , Ureter/cirurgia , Bexiga Urinária/patologia , Bexiga Urinária/cirurgia , Micção/efeitos dos fármacosRESUMO
A twelve-year retrospective study reviewing circumcision in 107 patients showed that of 94 patients with balanoposthitis 25.5 per cent had diagnosed diabetes mellitus while 3.2 per cent had unknown diabetes. In the fifty- to sixty-year-old age group, 83.3 per cent of circumcised patients had diabetes. In this age bracket there is a definite correlation of a diabetes-related need for circumcision. There is no significant histologic difference by light microscopy between prepuces in diabetic and nondiabetic patients.
