Assuntos
Refluxo Gastroesofágico/etiologia , Gastroenteropatias/cirurgia , Complicações Pós-Operatórias/etiologia , Adolescente , Adulto , Idoso , Refluxo Biliar/complicações , Refluxo Biliar/etiologia , Feminino , Refluxo Gastroesofágico/fisiopatologia , Refluxo Gastroesofágico/prevenção & controle , Humanos , Masculino , Manometria , Pessoa de Meia-Idade , Complicações Pós-Operatórias/prevenção & controleRESUMO
Simultaneous recordings of electrical and mechanical activities at different levels of the oesophagus were performed in normal men before and after physostigmine and metoclopramide injections. Various parameters of the basal oesophageal peristalsis were significantly modified following drug treatment. In particular, physostigmine injections induced a shortening of electromechanical coupling time and a reduction of the propagation velocities of the electrical and mechanical oesophageal events. Metoclopramide shortened the electromechanical coupling time but increased the electrical and mechanical propagation velocities along the oesophagus.
Assuntos
Esôfago/fisiologia , Metoclopramida/farmacologia , Fisostigmina/farmacologia , Eletrodos , Humanos , Peristaltismo/efeitos dos fármacosRESUMO
Pressure recordings in the esophageal body, LES and stomach were performed in 10 healthy subjects before and after caloric stimulation of the labyrinth. While esophageal and stomach responses varied or were absent, all subjects showed variations at the LES level. Duration of LES relaxation was increased and both time and amplitude of LES augmentation were significantly reduced. The physiological mechanism of labyrinthine-digestive connections and the possibility of clinical applications are discussed.
