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OBJECTIVES: To investigate the safety of administering low-dose aspirin (81 mg) 18 hours after intravenous thrombolytic therapy. METHODS: This is a retrospective cohort investigation. Individuals received either alteplase or tenecteplase for acute ischemic stroke followed by aspirin 81 mg (after follow-up imaging). An institutional change moved follow-up post-thrombolytic CT scans to 18 hours, and qualifying patients were grouped based on whether they received aspirin ≤24 hours or >24 hours. Chart reviews were conducted to assess the primary outcome of new or worsening intracranial hemorrhage, as well as secondary outcomes of change in stroke scale scores at discharge and 3 months, lengths of stay, favorable outcomes at 3 months, hospital readmission, and mortality. RESULTS: Out of 350 patients screened, 130 qualified for inclusion-50 of whom received aspirin ≤24 hours (mean 21.1 hours, SD±6.2), and 80 who received aspirin >24 hours (mean 34 hours, SD±8.2). Only 1 new intracranial bleed occurred following aspirin administration in the >24-hour group. No statistically significant differences were observed in any of the secondary outcomes, although there was higher mortality (3/50 vs. 2/80, P=0.372) and shorter hospital length of stay (median difference -1.0 day, P=0.0336) in the <24 hours group. CONCLUSIONS: Low-dose aspirin administration sooner than 24 hours following thrombolytic therapy did not increase bleeding events. Sooner aspirin administration after ischemic stroke can potentially enhance the prevention of secondary embolization and did not demonstrate worse clinical outcomes; however, further randomized controlled trials are needed.
RESUMO
INTRODUCTION: The American Association of Colleges of Pharmacy's vision statement is part of a national strategic endeavor to elevate pharmacy's professional profile. Community populations lack awareness of the unique roles and responsibilities of pharmacists. To positively influence the pipeline of future pharmacists, it is necessary to promote pharmacy as a career path. Proactively targeting younger age groups to engage in science, technology, engineering, mathematics, and health (STEM+H) educational activities will increase knowledge and understanding of the profession of pharmacy. Educational engagement is most successful when a positive relationship is established with a community alliance. PERSPECTIVE: Doctor of pharmacy students established a community partnership to create the inaugural "Girl Scouting Out Pharmacy" event. Over forty pharmacy students and faculty created and led an interactive event to advocate for the betterment of our profession while simultaneously educating on various pharmacy topics. Four unique, hands-on sessions incorporated pharmacy activities for girl scouts and their parents. These activities engaged youth to imagine their future while promoting an appreciation of pharmacy careers. IMPLICATIONS: Creating unique events to promote STEM+H education grants early opportunities to explore pharmacy-related concepts. The combination of healthcare professional students and community outreach produces the greatest potential to spark interest. Pharmacists have a duty to inspire young individuals, ensuring the next generation meets the needs of the nation's workforce. It is the responsibility of today's pharmacists to foster intellectual curiosity and instill a progressive drive in the following generation, lest we fall behind the curve on an ever-evolving healthcare culture.
