Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 26
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Synthese ; 203(5): 154, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38706520

RESUMO

Natural language syntax yields an unbounded array of hierarchically structured expressions. We claim that these are used in the service of active inference in accord with the free-energy principle (FEP). While conceptual advances alongside modelling and simulation work have attempted to connect speech segmentation and linguistic communication with the FEP, we extend this program to the underlying computations responsible for generating syntactic objects. We argue that recently proposed principles of economy in language design-such as "minimal search" criteria from theoretical syntax-adhere to the FEP. This affords a greater degree of explanatory power to the FEP-with respect to higher language functions-and offers linguistics a grounding in first principles with respect to computability. While we mostly focus on building new principled conceptual relations between syntax and the FEP, we also show through a sample of preliminary examples how both tree-geometric depth and a Kolmogorov complexity estimate (recruiting a Lempel-Ziv compression algorithm) can be used to accurately predict legal operations on syntactic workspaces, directly in line with formulations of variational free energy minimization. This is used to motivate a general principle of language design that we term Turing-Chomsky Compression (TCC). We use TCC to align concerns of linguists with the normative account of self-organization furnished by the FEP, by marshalling evidence from theoretical linguistics and psycholinguistics to ground core principles of efficient syntactic computation within active inference.

3.
Nat Commun ; 14(1): 6336, 2023 10 24.
Artigo em Inglês | MEDLINE | ID: mdl-37875526

RESUMO

Language depends critically on the integration of lexical information across multiple words to derive semantic concepts. Limitations of spatiotemporal resolution have previously rendered it difficult to isolate processes involved in semantic integration. We utilized intracranial recordings in epilepsy patients (n = 58) who read written word definitions. Descriptions were either referential or non-referential to a common object. Semantically referential sentences enabled high frequency broadband gamma activation (70-150 Hz) of the inferior frontal sulcus (IFS), medial parietal cortex, orbitofrontal cortex (OFC) and medial temporal lobe in the left, language-dominant hemisphere. IFS, OFC and posterior middle temporal gyrus activity was modulated by the semantic coherence of non-referential sentences, exposing semantic effects that were independent of task-based referential status. Components of this network, alongside posterior superior temporal sulcus, were engaged for referential sentences that did not clearly reduce the lexical search space by the final word. These results indicate the existence of complementary cortical mosaics for semantic integration in posterior temporal and inferior frontal cortex.


Assuntos
Mapeamento Encefálico , Semântica , Humanos , Mapeamento Encefálico/métodos , Encéfalo/fisiologia , Idioma , Lobo Temporal/fisiologia , Imageamento por Ressonância Magnética/métodos
4.
Harmful Algae ; 127: 102471, 2023 08.
Artigo em Inglês | MEDLINE | ID: mdl-37544671

RESUMO

Shellfish contamination with azaspiracids (AZA) is a major and recurrent problem for the Irish shellfish industry. Amphidoma languida, a small thecate dinoflagellate of the family Amphidomataceae, is widely distributed in Irish coastal waters and is one of the identified source species of azaspiracids. Irish and North Sea strains of Am. languida have been found to produce as major metabolites AZA-38 and -39 whose structures have only been provisionally elucidated by mass spectrometry and their toxic potential is currently unknown. In order to provide pure AZA-38 and -39 for subsequent structural and toxicological analyses, we present the first successful large-scale culture of Am. languida. A 180 L in house prototype bioreactor was used for culture growth and harvesting in semi-continuous mode for two months. Two different runs of the photobiorector with different light and pH setting showed the highest toxin yield at higher light intensity and slightly higher pH. AZA-38 and -39 cell quota were measured throughout the complete growth cycle with AZA-39 cell quota increasing in proportion to AZA-38 at late stationary to senescence phase. Over two experiments a total of 700 L of culture was harvested yielding 0.45 mg of pure AZA-39. The structure of AZA-39 was elucidated through NMR data analyses, which led to a revision of the structure proposed previously by mass spectrometry. While the spirotetrahydrofuran/tetrahydrofuran of rings A and B has been confirmed by NMR for AZA-39, a methyl is still present in position C-14 and the carboxylic acid chain is different from the structure proposed initially.


Assuntos
Dinoflagellida , Dinoflagellida/química , Fotobiorreatores , Espectrometria de Massas , Frutos do Mar/análise
5.
iScience ; 26(7): 107223, 2023 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-37485361

RESUMO

Language and music involve the productive combination of basic units into structures. It remains unclear whether brain regions sensitive to linguistic and musical structure are co-localized. We report an intraoperative awake craniotomy in which a left-hemispheric language-dominant professional musician underwent cortical stimulation mapping (CSM) and electrocorticography of music and language perception and production during repetition tasks. Musical sequences were melodic or amelodic, and differed in algorithmic compressibility (Lempel-Ziv complexity). Auditory recordings of sentences differed in syntactic complexity (single vs. multiple phrasal embeddings). CSM of posterior superior temporal gyrus (pSTG) disrupted music perception and production, along with speech production. pSTG and posterior middle temporal gyrus (pMTG) activated for language and music (broadband gamma; 70-150 Hz). pMTG activity was modulated by musical complexity, while pSTG activity was modulated by syntactic complexity. This points to shared resources for music and language comprehension, but distinct neural signatures for the processing of domain-specific structural features.

6.
Proc Natl Acad Sci U S A ; 120(17): e2300252120, 2023 04 25.
Artigo em Inglês | MEDLINE | ID: mdl-37068244

RESUMO

Reading a sentence entails integrating the meanings of individual words to infer more complex, higher-order meaning. This highly rapid and complex human behavior is known to engage the inferior frontal gyrus (IFG) and middle temporal gyrus (MTG) in the language-dominant hemisphere, yet whether there are distinct contributions of these regions to sentence reading is still unclear. To probe these neural spatiotemporal dynamics, we used direct intracranial recordings to measure neural activity while reading sentences, meaning-deficient Jabberwocky sentences, and lists of words or pseudowords. We isolated two functionally and spatiotemporally distinct frontotemporal networks, each sensitive to distinct aspects of word and sentence composition. The first distributed network engages the IFG and MTG, with IFG activity preceding MTG. Activity in this network ramps up over the duration of a sentence and is reduced or absent during Jabberwocky and word lists, implying its role in the derivation of sentence-level meaning. The second network engages the superior temporal gyrus and the IFG, with temporal responses leading those in frontal lobe, and shows greater activation for each word in a list than those in sentences, suggesting that sentential context enables greater efficiency in the lexical and/or phonological processing of individual words. These adjacent, yet spatiotemporally dissociable neural mechanisms for word- and sentence-level processes shed light on the richly layered semantic networks that enable us to fluently read. These results imply distributed, dynamic computation across the frontotemporal language network rather than a clear dichotomy between the contributions of frontal and temporal structures.


Assuntos
Mapeamento Encefálico , Imageamento por Ressonância Magnética , Humanos , Imageamento por Ressonância Magnética/métodos , Idioma , Linguística , Lobo Frontal/fisiologia , Semântica
7.
ArXiv ; 2023 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-36994166

RESUMO

A comprehensive model of natural language processing in the brain must accommodate four components: representations, operations, structures and encoding. It further requires a principled account of how these different components mechanistically, and causally, relate to each another. While previous models have isolated regions of interest for structure-building and lexical access, and have utilized specific neural recording measures to expose possible signatures of syntax, many gaps remain with respect to bridging distinct scales of analysis that map onto these four components. By expanding existing accounts of how neural oscillations can index various linguistic processes, this article proposes a neurocomputational architecture for syntax, termed the ROSE model (Representation, Operation, Structure, Encoding). Under ROSE, the basic data structures of syntax are atomic features, types of mental representations (R), and are coded at the single-unit and ensemble level. Elementary computations (O) that transform these units into manipulable objects accessible to subsequent structure-building levels are coded via high frequency broadband γ activity. Low frequency synchronization and cross-frequency coupling code for recursive categorial inferences (S). Distinct forms of low frequency coupling and phase-amplitude coupling (δ-θ coupling via pSTS-IFG; θ-γ coupling via IFG to conceptual hubs in lateral and ventral temporal cortex) then encode these structures onto distinct workspaces (E). Causally connecting R to O is spike-phase/LFP coupling; connecting O to S is phase-amplitude coupling; connecting S to E is a system of frontotemporal traveling oscillations; connecting E back to lower levels is low-frequency phase resetting of spike-LFP coupling. This compositional neural code has important implications for algorithmic accounts, since it makes concrete predictions for the appropriate level of study for psycholinguistic parsing models. ROSE is reliant on neurophysiologically plausible mechanisms, is supported at all four levels by a range of recent empirical research, and provides an anatomically precise and falsifiable grounding for the basic property of natural language syntax: hierarchical, recursive structure-building.

8.
Cogn Sci ; 46(10): e13207, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-36251414

RESUMO

Human language affords the ability to attribute semantically distinct concepts to a single nominal, a process now commonly termed 'copredication'. If we describe a lunch as being delayed but also filling , senses of distinct semantic categories (event, physical object) are simultaneously being accessed. Copredication is relevant to major debates in cognitive science, since it cuts to the core of how the lexicon is formatted, and how distinct lexico-semantic representations relate to each other. The apparent scope and limits of copredication licensing can be explored via acceptability judgment and processing experiments, exposing certain replicable and generalizable patterns that apply across lexical types, syntactic structures, and different languages (Murphy 2021a, 2021b). As such, laying out the psycholinguistic terrain in which to address this phenomenon is crucial - and accounts that lack a valid psycholinguistic and empirical basis should be highlighted as problematic if they are to be accommodated and refined. Löhr and Michel (2022) claim that copredication acceptability is determined by a "set of expectations that are influenced by higher-order priors associated with discourse context and world knowledge". I will show that their model encounters a number of obstacles, and ends up unintentionally supporting an alternative model in Murphy (2019, 2021a, 2021b, 2021c), which they attempt to critique.


Assuntos
Idioma , Semântica , Humanos , Julgamento , Psicolinguística
9.
Proc Natl Acad Sci U S A ; 119(23): e2201651119, 2022 06 07.
Artigo em Inglês | MEDLINE | ID: mdl-35648823

Assuntos
Idioma , Aprendizagem
10.
J Neurosci ; 42(15): 3216-3227, 2022 04 13.
Artigo em Inglês | MEDLINE | ID: mdl-35232761

RESUMO

The ability to comprehend phrases is an essential integrative property of the brain. Here, we evaluate the neural processes that enable the transition from single-word processing to a minimal compositional scheme. Previous research has reported conflicting timing effects of composition, and disagreement persists with respect to inferior frontal and posterior temporal contributions. To address these issues, 19 patients (10 male, 9 female) implanted with penetrating depth or surface subdural intracranial electrodes, heard auditory recordings of adjective-noun, pseudoword-noun, and adjective-pseudoword phrases and judged whether the phrase matched a picture. Stimulus-dependent alterations in broadband gamma activity, low-frequency power, and phase-locking values across the language-dominant left hemisphere were derived. This revealed a mosaic located on the lower bank of the posterior superior temporal sulcus (pSTS), in which closely neighboring cortical sites displayed exclusive sensitivity to either lexicality or phrase structure, but not both. Distinct timings were found for effects of phrase composition (210-300 ms) and pseudoword processing (∼300-700 ms), and these were localized to neighboring electrodes in pSTS. The pars triangularis and temporal pole encoded anticipation of composition in broadband low frequencies, and both regions exhibited greater functional connectivity with pSTS during phrase composition. Our results suggest that the pSTS is a highly specialized region composed of sparsely interwoven heterogeneous constituents that encodes both lower and higher level linguistic features. This hub in pSTS for minimal phrase processing may form the neural basis for the human-specific computational capacity for forming hierarchically organized linguistic structures.SIGNIFICANCE STATEMENT Linguists have claimed that the integration of multiple words into a phrase demands a computational procedure distinct from single-word processing. Here, we provide intracranial recordings from a large patient cohort, with high spatiotemporal resolution, to track the cortical dynamics of phrase composition. Epileptic patients volunteered to participate in a task in which they listened to phrases (red boat), word-pseudoword or pseudoword-word pairs (e.g., red fulg). At the onset of the second word in phrases, greater broadband high gamma activity was found in posterior superior temporal sulcus in electrodes that exclusively indexed phrasal meaning and not lexical meaning. These results provide direct, high-resolution signatures of minimal phrase composition in humans, a potentially species-specific computational capacity.


Assuntos
Área de Broca , Idioma , Encéfalo , Mapeamento Encefálico , Feminino , Humanos , Linguística , Masculino , Semântica
11.
Front Psychol ; 12: 528862, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34916982

RESUMO

The conditions under which certain complex polysemous nominals can sustain coherent sense relations (informally, can "survive") is investigated through a two-alternative forced choice experiment. Written scenarios were constructed which permitted copredication, through which multiple, semantically different sense types are associated with a single nominal. Participants were presented with two scenarios involving a polysemous nominal (e.g., bank, city) and had to select which scenario (and, hence, which combination of predicates) appeared to be the most prototypical, faithful realization of the nominal. In order to achieve this, an additional manipulation was added, such that the number of senses hosted by each forced choice was either equal (2 senses choice vs. 2 senses choice) or unequal (1 sense choice vs. 2/3 senses choice). In order to address certain concerns in the literature about prototypicality, a core question addressed was whether the institutional sense of the nominals strongly determined the option chosen by participants, or whether the number of senses more strongly predicted this. It was found that the best predictor of sense "survival" was not sense frequency, but rather sense complexity or approximation to the institutional sense.

12.
Int J Mol Sci ; 22(22)2021 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-34830076

RESUMO

Microalgae have received growing interest for their capacity to produce bioactive metabolites. This study aimed at characterising the antimicrobial potential of the marine dinoflagellate Amphidinium carterae strain LACW11, isolated from the west of Ireland. Amphidinolides have been identified as cytotoxic polyoxygenated polyketides produced by several Amphidinium species. Phylogenetic inference assigned our strain to Amphidinium carterae subclade III, along with isolates interspersed in different geographic regions. A two-stage extraction and fractionation process of the biomass was carried out. Extracts obtained after stage-1 were tested for bioactivity against bacterial ATCC strains of Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa. The stage-2 solid phase extraction provided 16 fractions, which were tested against S. aureus and E. faecalis. Fractions I, J and K yielded minimum inhibitory concentrations between 16 µg/mL and 256 µg/mL for both Gram-positive. A targeted metabolomic approach using UHPLC-HRMS/MS analysis applied on fractions G to J evidenced the presence of amphidinol type compounds AM-A, AM-B, AM-22 and a new derivative dehydroAM-A, with characteristic masses of m/z 1361, 1463, 1667 and 1343, respectively. Combining the results of the biological assays with the targeted metabolomic approach, we could conclude that AM-A and the new derivative dehydroAM-A are responsible for the detected antimicrobial bioactivity.


Assuntos
Antibacterianos/farmacologia , Organismos Aquáticos/química , Bactérias/crescimento & desenvolvimento , Compostos Bicíclicos Heterocíclicos com Pontes/farmacologia , Dinoflagellida/química , Macrolídeos/farmacologia , Antibacterianos/química , Organismos Aquáticos/crescimento & desenvolvimento , Compostos Bicíclicos Heterocíclicos com Pontes/química , Dinoflagellida/crescimento & desenvolvimento , Macrolídeos/química
13.
Front Psychol ; 11: 2101, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32982860
14.
Front Behav Neurosci ; 13: 190, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31551725

RESUMO

We explore the potential that brain oscillations have for improving our understanding of how language develops, is processed in the brain, and initially evolved in our species. The different synchronization patterns of brain rhythms can account for different perceptual and cognitive functions, and we argue that this includes language. We aim to address six distinct questions-the What, How, Where, Who, Why, and When questions-pertaining to oscillatory investigations of language. Language deficits found in clinical conditions like autism, schizophrenia and dyslexia can be satisfactorily construed in terms of an abnormal, disorder-specific pattern of brain rhythmicity. Lastly, an eco-evo-devo approach to language is defended with explicit reference to brain oscillations, embracing a framework that considers language evolution to be the result of a changing environment surrounding developmental paths of the primate brain.

15.
Front Psychol ; 10: 1448, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31275219

RESUMO

Language evolution has long been researched. I will review a number of broad, emerging research directions which arguably have the potential to contribute to our understanding of language evolution. Emerging topics in genomics and neurolinguistics are explored, and human-specific levels of braincase globularity - and the broader process of self-domestication within which globularity seems capable of being encapsulated - will be argued to be the central pillars of any satisfactory and interdisciplinary model of language evolution.

16.
J Anthropol Sci ; 96: 111-124, 2018 Dec 31.
Artigo em Inglês | MEDLINE | ID: mdl-30566085

RESUMO

Language seemingly evolved from changes in brain anatomy and wiring. We argue that language evolution can be better understood if particular changes in phasal and cross-frequency coupling properties of neural oscillations, resulting in core features of language, are considered. Because we cannot track the oscillatory activity of the brain from extinct hominins, we used our current understanding of the language oscillogenome (that is, the set of genes responsible for basic aspects of the oscillatory activity relevant for language) to infer some properties of the Neanderthal oscillome. We have found that several candidates for the language oscillogenome show differences in their methylation patterns between Neanderthals and humans. We argue that differences in their expression levels could be informative of differences in cognitive functions important for language.


Assuntos
Evolução Cultural , Idioma , Homem de Neandertal , Fala/fisiologia , Animais , Antropologia Física , Biologia Computacional , Metilação de DNA/genética , Técnicas Genéticas , Homem de Neandertal/genética , Homem de Neandertal/fisiologia , Fenômenos Fisiológicos do Sistema Nervoso/genética
17.
Front Psychol ; 9: 1999, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30405489

RESUMO

Language has been argued to arise, both ontogenetically and phylogenetically, from specific patterns of brain wiring. We argue that it can further be shown that core features of language processing emerge from particular phasal and cross-frequency coupling properties of neural oscillations; what has been referred to as the language 'oscillome.' It is expected that basic aspects of the language oscillome result from genetic guidance, what we will here call the language 'oscillogenome,' for which we will put forward a list of candidate genes. We have considered genes for altered brain rhythmicity in conditions involving language deficits: autism spectrum disorders, schizophrenia, specific language impairment and dyslexia. These selected genes map on to aspects of brain function, particularly on to neurotransmitter function. We stress that caution should be adopted in the construction of any oscillogenome, given the range of potential roles particular localized frequency bands have in cognition. Our aim is to propose a set of genome-to-language linking hypotheses that, given testing, would grant explanatory power to brain rhythms with respect to language processing and evolution.

18.
Front Psychol ; 8: 1072, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28701983

RESUMO

Much is known about the acquisition of phonological competence and lexical categories, but there has been substantially less research into word meaning development. In an attempt to contribute to this debate, a group of 24 children aged 4-11 were asked to define a set of words, as were a group of 12 adult controls. The stimuli included both concrete and abstract words, in particular words exhibiting a rare form of polysemy known as copredication, which permits the simultaneous attribution of concrete and abstract senses to a single nominal, creating an 'impossible' entity. The results were used to track the developmental trajectory of copredication, previously unexplored in the language acquisition literature.

19.
Neurosci Biobehav Rev ; 83: 742-764, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27475632

RESUMO

Schizophrenia (SZ) and autism spectrum disorders (ASD) are characterised by marked language deficits, but it is not clear how these arise from gene mutations associated with the disorders. Our goal is to narrow the gap between SZ and ASD and, ultimately, give support to the view that they represent abnormal (but related) ontogenetic itineraries for the human faculty of language. We will focus on the distinctive oscillatory profiles of the SZ and ASD brains, in turn using these insights to refine our understanding of how the brain implements linguistic computations by exploring a novel model of linguistic feature-set composition. We will argue that brain rhythms constitute the best route to interpreting language deficits in both conditions and mapping them to neural dysfunction and risk alleles of the genes. Importantly, candidate genes for SZ and ASD are overrepresented among the gene sets believed to be important for language evolution. This translational effort may help develop an understanding of the aetiology of SZ and ASD and their high prevalence among modern populations.


Assuntos
Transtorno Autístico/complicações , Encéfalo/fisiopatologia , Transtornos da Linguagem/etiologia , Esquizofrenia/complicações , Transtorno Autístico/genética , Transtorno Autístico/patologia , Conectoma , Humanos , Transtornos da Linguagem/genética , Transtornos da Linguagem/patologia , Esquizofrenia/genética , Esquizofrenia/patologia
20.
Front Hum Neurosci ; 10: 422, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27601987

RESUMO

Schizophrenia is characterized by marked language deficits, but it is not clear how these deficits arise from the alteration of genes related to the disease. The goal of this paper is to aid the bridging of the gap between genes and schizophrenia and, ultimately, give support to the view that the abnormal presentation of language in this condition is heavily rooted in the evolutionary processes that brought about modern language. To that end we will focus on how the schizophrenic brain processes language and, particularly, on its distinctive oscillatory profile during language processing. Additionally, we will show that candidate genes for schizophrenia are overrepresented among the set of genes that are believed to be important for the evolution of the human faculty of language. These genes crucially include (and are related to) genes involved in brain rhythmicity. We will claim that this translational effort and the links we uncover may help develop an understanding of language evolution, along with the etiology of schizophrenia, its clinical/linguistic profile, and its high prevalence among modern populations.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...