Longitudinal Interplay Between Alcohol Use, Mood, and Functioning in Bipolar Spectrum Disorders.

Importance: Alcohol use disorder (AUD) is present in nearly half of individuals with bipolar disorder (BD) and is associated with markedly worsening outcomes. Yet, the concurrent treatment of BD and AUD remains neglected in both research and clinical care; characterizing their dynamic interplay is crucial in improving outcomes. Objective: To characterize the longitudinal alcohol use patterns in BD and examine the temporal associations among alcohol use, mood, anxiety, and functioning over time. Design, Setting, and Participants: This cohort study selected participants and analyzed data from the Prechter Longitudinal Study of Bipolar Disorder (PLS-BD), an ongoing cohort study that recruits through psychiatric clinics, mental health centers, and community outreach events across Michigan and collects repeated phenotypic data. Participants selected for the present study were those with a diagnosis of BD type I (BDI) or type II (BDII) who had been in the study for at least 5 years. Data used were extracted from February 2006 to April 2022, and follow-up ranged from 5 to 16 years. Main Outcomes and Measures: Alcohol use was measured using the Alcohol Use Disorders Identification Test. Depression, mania or hypomania, anxiety, and functioning were measured using the 9-Item Patient Health Questionnaire, the Altman Self-Rating Mania Scale, the 7-item Generalized Anxiety Disorder assessment scale, and the Life Functioning Questionnaire, respectively. Results: A total of 584 individuals (386 females (66.1%); mean [SD] age, 40 [13.6] years) were included. These participants had a BDI (445 [76.2%]) or BDII (139 [23.8%]) diagnosis, with or without a lifetime diagnosis of AUD, and a median (IQR) follow-up of 9 (0-16) years. More problematic alcohol use was associated with worse depressive (ß = 0.04; 95% credibility interval [CrI], 0.01-0.07) and manic or hypomanic symptoms (ß = 0.04; 95% CrI, 0.01-0.07) as well as lower workplace functioning (ß = 0.03; 95% CrI, 0.00-0.06) over the next 6 months, but increased depressive and manic or hypomanic symptoms were not associated with greater subsequent alcohol use. These latter 2 associations were more pronounced in BDII than BDI (mania or hypomania: ß = 0.16 [95% CrI, 0.02-0.30]; workplace functioning: ß = 0.26 [95% CrI, 0.06-0.45]). Alcohol use was not associated with anxiety over time. Conclusions and Relevance: This study found that alcohol use, regardless of diagnostic status, was associated with mood instability and poorer work functioning in BD, but increased mood symptoms were not associated with subsequent alcohol use. Given its prevalence and repercussions, dimensional and longitudinal assessment and management of alcohol use are necessary and should be integrated into research and standard treatment of BD.

Comparing parent-child interaction during wordless book reading, print book reading and imaginative play.

This study investigated differences in adult-child language interactions when parents and their three-to-four-year old children engage in wordless book reading, text-and-picture book reading and a small-world toy play activity. Twenty-two parents recorded themselves completing each activity at home with their child. Parent input was compared across contexts, focusing on interactive and conceptual domains: use of open prompts, expansions or extensions of children's utterances, and use of decontextualised (abstract) language. Use of linguistic expansions was greater during book reading than toy play. Parents used open questions and added contingent conceptual information more often when reading wordless books than in both other conditions. Findings suggest that wordless books may combine the benefits of open-endedness and linguistic content based around a narrative. Parents' use of abstract language also varied by condition. This study extends understanding of the role of activity context in shaping children's language learning environments.

Measuring knowledge of multiple word meanings in children with English as a first and an additional language and the relationship to reading comprehension.

Polysemy, or the property of words having multiple meanings, is a prevalent feature of vocabulary. In this study we validated a new measure of polysemy knowledge for children with English as an additional language (EAL) and a first language (EL1) and examined the relationship between polysemy knowledge and age, language status, and reading comprehension. Participants were 112 British children aged 5 to 6 (n = 61) or 8 to 9 years (n = 51), 37% of whom had EAL (n = 41). Participants completed the new measure of knowledge of polysemes, along with other measures of language, literacy and cognitive ability. The new measure was reliable and valid with EAL and EL1 children. Age and language status predicted children's polyseme knowledge. Polyseme knowledge uniquely contributed to reading comprehension after controlling for age, language status, non-verbal intelligence, time reading in English, and breadth of vocabulary. This research underscores the importance of polysemy for children's linguistic development.

Understanding how time flies and what it means to be on cloud nine: English as an Additional Language (EAL) learners' metaphor comprehension.

We explored the vocabulary and metaphor comprehension of learners of English as an additional language (EAL) in the first two years of UK primary school. EAL vocabulary knowledge is believed to be a crucial predictor of (reading) comprehension and educational attainment (Murphy, 2018). The vocabulary of five- to seven-year-old children with EAL was compared to that of English monolinguals (N = 80). Comprehension was assessed for both verbal (e.g., time flies) and nominal metaphors (be on cloud nine) of varying frequency. Results showed that children in year 2 (age six to seven years) had better comprehension than their younger (age five to six) peers, particularly for low-frequency metaphors. Children with EAL had weaker metaphor comprehension than their monolingual peers, particularly on a reasoning task. The results document how metaphor comprehension develops over the first critical years of schooling and indicates where learners with EAL differ from monolingual peers, thereby supporting targeted vocabulary teaching at primary schools.

Morphosyntax in children with word finding difficulties.

Children with word finding difficulties (CwWFDs) are slower and less accurate at naming monomorphemic words than typically developing children (Dockrell, Messer & George, 2001), but their difficulty in naming morphologically complex words has not yet been investigated. One aim of this paper was to identify whether CwWFDs are similar to typically developing children at producing inflected (morphologically complex) words. A second aim was to investigate whether the dual-mechanism model could account for the use of morphology in a sample of CwWFDs, exemplifying the notion that regular inflections are part of a rule-based system and computed on-line, while irregular inflections are retrieved directly from the associative system (Pinker, 1999). The inflectional knowledge of a group of CwWFDs was compared against a group of language age-matched typically developing peers in three experiments. In Experiment 1 children produced the past tenses of high- and low-frequency regular and irregular English verbs. In Experiment 2 children generalized their knowledge of the past tense system onto nonsense verbs and in Experiment 3 children produced past tenses of verbs used in either a denominal or a verb root context. In each of these three studies, the CwWFDs performed similarly to matched typical children, suggesting that they do not have a selective problem with morphosyntactic features of words. The findings provide mixed support for the dual-mechanism model.

Rule learning by rats.

Using rules extracted from experience to solve problems in novel situations involves cognitions such as analogical reasoning and language learning and is considered a keystone of humans' unique abilities. Nonprimates, it has been argued, lack such rule transfer. We report that Rattus norvegicus can learn simple rules and apply them to new situations. Rats learned that sequences of stimuli consistent with a rule (such as XYX) were different from other sequences (such as XXY or YXX). When novel stimuli were used to construct sequences that did or did not obey the previously learned rule, rats transferred their learning. Therefore, rats, like humans, can transfer structural knowledge from sequential experiences.

When answer-phone makes a difference in children's acquisition of English compounds.

Over the course of acquiring deverbal compounds like truck driver, English-speaking children pass through a stage when they produce ungrammatical compounds like drive-truck. These errors have been attributed to canonical phrasal ordering (Clark, Hecht & Mulford, 1986). In this study, we compared British and Canadian children's compound production. Both dialects have the same phrasal ordering but some different lexical items (e.g. answer-phone exists only in British English). If influenced by these lexical differences, British children would produce more ungrammatical Verb-Object (VO) compounds in trying to produce the more complex deverbal (Object-Verb-er) than the Canadian children. 36 British children between the ages of 3;6 and 5;6 and 36 age-matched Canadian children were asked to produce novel compounds (like sun juggler). The British children produced more ungrammatical compounds and fewer grammatical compounds than the Canadian children. We argue that children's errors in deverbal compounds may be due in part to competing lexical structures.

Modality effects in compounding with English inflectional morphology.

The treatment of plural morphemes in English noun-noun compounds is significant because it provides a test case for competing theories of language acquisition and representation. Even when the first noun in a compound refers to plural items, native speakers frequently use the singular form (Murphy, 2000). Sometimes, they will use the irregular plural form ('mice chaser') but very rarely are regular plurals ('rats chaser') used as the first noun in a compound. This effect has been found with native English-speaking children (Gordon, 1985; Nicoladis, 2000; Oetting & Rice, 1993; van der Lely & Christian, 2000); native English-speaking teenagers (van der Lely & Christian, 2000); and native English-speaking adults (Lardiere & Schwartz, 1997; Murphy, 2000). The apparent dissociation between regular and irregular plurals (i.e.that irregular plurals are included before a second noun but regular plurals are almost never included before a second noun) is thought to be due to innate morphological constraints (Marcus, Brinkmann, Clahsen, Weise, & Pinker, 1995). Such constraints predict that all items of regular morphology should be treated differently from all items of irregular morphology by language users in all situations. However, if external factors such as input and response modality affect the number of plurals included in compounds, then this questions the internal constraint-based explanations of compounding and encourages investigation of how external factors might influence the number of plurals included in compounds.

Serial order of conditional stimuli as a discriminative cue for Pavlovian conditioning.

The serial order in which events occur can be a signal for different outcomes and therefore might be a determinant of how an animal should respond. In this report, we propose a novel design for studying serial order learning in Pavlovian conditioning. In both Experiments 1a and 1b, hungry rats were trained with successively presented pairs of auditory and visual stimuli (e.g., A --> B) using four different stimuli (A-D). Four orders were paired with food (A --> B, B --> C, C --> D, D --> A) while the reversals were extinguished (B --> A, C --> B, D --> C, A --> D). An analysis of responding from the second element of each pair showed that the rats discriminated trial types that preceded food from those that did not. A replication of the effect using a completely counterbalanced design is described in Experiment 1b. These results suggest that rats can use the serial or temporal order of two sequentially presented non-overlapping elements as the basis for discrimination. Two associative accounts are suggested as possible mechanisms for solving the discrimination.

Level-ordering does not constrain children's ungrammatical compounds.

English-speaking children typically avoid using regular plurals in novel grammatical deverbal compounds as in rat eater but allow irregular plurals as in mice eater (Gordon, 19985). To explain these data, it has been argued that level-ordering model constrains the production of morphologically complex words, including those with which children have had little to no experience. If level-ordering can be supported, children should avoid regular plurals in their ungrammatical deverbal compounds like a breaker-bottle. Seventy-two English-speaking children were included in the present study, 36 from Britain and 36 from Canada. The results showed that 50% of the children who produced ungrammatical compounds included regular plurals in the compounds they produced. Conversely, none of the children who produced grammatical compounds included regular plurals. These results indicate that level-ordering does not constrain children's production of ungrammatical compounds. These results raise the possibility that level-ordering may not be a valid constraint of children's compounding in general.