First-trimester hyperglycosylated human chorionic gonadotropin and development of hypertension.

OBJECTIVE: This study aimed to determine whether urine levels of hyperglycosylated human chorionic gonadotropin (HhCG) in the first trimester are predictive of subsequent development of hypertension during pregnancy METHOD: This prospective cohort study consisted of women seeking care before 12 weeks gestation. A clean catch urine was obtained at the first prenatal visit and tested for HhCG and creatinine levels. The median HhCG levels and multiples of the median (MoM) by gestational age were compared between the groups that either developed hypertension or did not. RESULTS: Urine HhCG were determined for 204 women between 4 weeks 4 days to 11 weeks 6 days. The median HhCG of those who developed gestational hypertension (n = 7) or preeclampsia (n = 15) did not differ from the group that did not (median: 284 ng/mg creatinine vs 365 ng/mg; p = 0.55). If the MoM of HhCG for the no hypertension group was 1.00, the MoM of HhCG for the hypertension group was 0.93 (p = 0.93). A possible association was observed after 10 weeks between low HhCG levels and the development of late-onset hypertension (≥34 weeks). CONCLUSIONS: Prenatal screening for subsequent hypertension is unreliable with a single measurement of maternal urine HhCG at 10 weeks or less.

Distinguishing two contributions to the nearly constant loss in ion-conducting glasses.

In an effort to understand the origins of the nearly constant loss in disordered materials, we report dielectric studies of a series of sodium germanate glasses, (Na2O)(x)(GeO2)(1-x) for x=0, 0.003, 0.01, 0.03, and 0.1 at temperatures between 85 and 700 K. Analysis of the conductivity scaling for these glasses demonstrates the existence of two contributions in the near constant loss; one due to mobile cations that conforms to the same scaling properties found for ion hopping at high temperatures and the other due to the glass network which dominates at low temperatures and low ion densities.