The impact of age-related increase in passive muscle stiffness on simulated upper limb reaching.

Ageing changes the musculoskeletal and neural systems, potentially affecting a person's ability to perform daily living activities. One of these changes is increased passive stiffness of muscles, but its contribution to performance is difficult to separate experimentally from other ageing effects such as loss of muscle strength or cognitive function. A computational upper limb model was used to study the effects of increasing passive muscle stiffness on reaching performance across the model's workspace (all points reachable with a given model geometry). The simulations indicated that increased muscle stiffness alone caused deterioration of reaching accuracy, starting from the edges of the workspace. Re-tuning the model's control parameters to match the ageing muscle properties does not fully reverse ageing effects but can improve accuracy in selected regions of the workspace. The results suggest that age-related muscle stiffening, isolated from other ageing effects, impairs reaching performance. The model also exhibited oscillatory instability in a few simulations when the controller was tuned to the presence of passive muscle stiffness. This instability is not observed in humans, implying the presence of natural stabilizing strategies, thus pointing to the adaptive capacity of neural control systems as a potential area of future investigation in age-related muscle stiffening.

The impact of intrinsic muscle properties on simulated reaching performance.

Musculoskeletal modelling is used widely for studying limb motion and its control, but simulation outcomes may depend heavily on the underlying muscle model used. The aim of this study was to investigate how intrinsic muscle properties affect reaching movements in a simple upper limb model. The simulations suggest that more realistic, higher-order activation dynamics requires longer prediction from a forward model and gives rise to a higher level of unplanned co-contraction than simple activation models. Consistent with prior work, muscle force-length-velocity properties stabilised and smoothed limb movements and furthermore helped promote accurate reaching performance with the high-order activation model.

Indicators of anterior-posterior phase difference in glottal opening measured from natural production of vowels.

Voiced speech is generated by the glottal flow interacting with vocal fold vibrations. However, the details of vibrations in the anterior-posterior direction (the so-called zipper-effect) and their correspondence with speech and other glottal signals are not fully understood due to challenges in direct measurements of vocal fold vibrations. In this proof-of-concept study, the potential of four parameters extracted from high-speed videoendoscopy (HSV), electroglottography, and speech signals to indicate the presence of a zipper-type glottal opening is investigated. Comparison with manual labeling of the HSV videos highlighted the importance of multiple parameter-signal pairs in indicating the presence of a zipper-type glottal opening.

Skewing of the glottal flow with respect to the glottal area measured in natural production of vowels.

In the production of voiced speech, glottal flow skewing refers to the tilting of the glottal flow pulses to the right, often characterized as a delay of the peak, compared to the glottal area. In the past four decades, several studies have addressed this phenomenon using modeling of voice production with analog circuits and computer simulations. However, previous studies measuring flow skewing in natural production of speech are sparse and they contain little quantitative data about the degree of skewing between flow and area. In the current study, flow skewing was measured from the natural production of 40 vowel utterances produced by 10 speakers. Glottal flow was measured from speech using glottal inverse filtering and glottal area was captured with high-speed videoendoscopy. The estimated glottal flow and area waveforms were parameterized with four robust parameters that measure pulse skewness quantitatively. Statistical tests obtained for all four parameters showed that the flow pulse was significantly more skewed to the right than the area pulse. Hence, this study corroborates the existence of flow skewing using measurements from natural speech production. In addition, the study yields quantitative data about pulse skewness in simultaneous measured glottal flow and area in natural production of speech.

Preliminary estimate of immediate cost of chikungunya and dengue to Gujarat, India.

This study aims to provide a preliminary estimate of the immediate cost of chikungunya and dengue to household in the Indian state of Gujarat. Combining nine earlier studies and data from interviews, we analysed the costs of non-fatal illness and of intervention programmes; building a more comprehensive picture of the immediate cost of these Aedes aegypti mosquito-borne diseases to Gujarat. The “RUHA matrix” was used to estimate the cost of illness by combining the shares of reported (R) and unreported (U) hospitalized (H) and ambulatory (A) cases of chikungunya and dengue with ambulatory and hospitalization costs per case and the number of reported cases. Using Monte Carlo sensitivity analysis, the immediate cost to households incurred on account of chikungunya and dengue to Gujarat was estimated to be 3.8 (range 1.6–9.1) billion Indian rupees (INR) per annum (US$ 90 million, range US$ 38 and US$ 217 million). It is hoped that this preliminary estimate will trigger more refined studies on cost of illness as well as cost-effectiveness of vaccines and other interventions to combat these neglected tropical diseases.