[Cytological, cytochemical and ultrastructural characteristics of breast cancer]. / Tsitologicheskaia, tsitokhimicheskaia u ul'trastrukturnaia kharakteristika raka molochnoi zhelezy.

Cytohistological, cytochemical, and ultrastructural methods were used to study 115 mammary gland carcinomas. Cytological verification of different forms of mammary gland carcinoma is substantiated on the basis of comparative evaluation of cytological and histological features of the tumor. Examination of impression smears of removed mammary gland tumors allowed not only to establish the diagnosis of carcinoma in 98.2% of the cases but also to recognize its various forms. Different forms of mammary gland carcinoma have been characterized ultrastructurally. A correlation between the glycogen content in tumor cells and morphological structure of the tumor was established.

[DNA content in the nuclei of breast cancer cells and their metastases to the regional lymph nodes analyzed by impulse cytophotometry]. / Izuchenie soderzhaniia DNK v iadrakh kletok raka molochnoi zhelezy i ego metastazov v regionarnykh limfaticheskikh uzlakh metodom impul'snoi tsitofotometrii.

The data are reaorted on the distribution of the DNA content in cell nuclei of normal human mammary gland, in benign processes, cancer and its metastases in regional lymphnodes by the method of impulse cytophotometry. In benign processes the distribution of DNA in epithelial cells was not shown to differ from the control, however, in some cases there is an increased proliferative activity of the epithelium. Cytophotometrical structure of human breast cancer in general traits reflects the pattern of DNA distribution in them. A tumor consisting of monomorphous elements more frequently shows one type of tumor cells with a different degree of their proliferative activity. The presence of large number of anaplastic cells would correspond to the peaks of anaeploid and polyploid cells on DNA-histograms. A correlation between the DNA content in epithelial cell nuclei of the primary tumor and its metastases in regional lymph nodes was found to remain in the uniform cytologic picture.