RESUMO
BACKGROUND: Krukenberg tumour (KT) is clinically defined as any ovarian metastatic carcinoma derived from a primary malignancy (usually from the gastrointestinal tract). Our aim was to analyse the incidence, demographic profile, clinical features, management and survival of patients with KTs from gastrointestinal tract malignancies at our centre. METHODS: This was a retrospective analysis data at our centre between Jan 2015 and Dec 2017. RESULTS: A total of 8 patients of KTs (2 from gastric and 6 from colorectal cancers) were observed with an incidence of 0.66% in gastric and 2.90% in colorectal cancers. The mean age of all the patients was 40 years (44 in gastric and 39 in colorectal group) and most of them (5 out of 8) occurred in premenopausal women. They were also most commonly bilateral (6 out of 8) and synchronous (6 out of 8). Surgical debulking was possible in 7 patients and all patients underwent systemic chemotherapy. Interestingly, 4 patients in the colorectal KT group with metastasis limited to ovary alone managed by surgical debulking and chemotherapy had a significantly higher 1-year survival compared to the others with peritoneal disease are alive at an average of 14.5 months. CONCLUSIONS: The incidence of KTs from colorectal cancers is on the rise. KTs from colorectal cancers and KTs without peritoneal metastases have a better prognosis showing significantly higher 1-year survival rates following complete surgical resection and systemic chemotherapy.
RESUMO
BACKGROUND: Massive hemobilia is a rare but potentially life-threatening cause of upper gastrointestinal hemorrhage. In this retrospective analysis, we have evaluated the challenges involved in the diagnosis and management of massive hemobilia. METHODS: Between 2001 and 2011, a total of 20 consecutive patients (14 males) who were treated in our department for massive hemobilia were included in the study and their records were retrospectively analyzed. RESULTS: Causes of hemobilia were blunt liver trauma (n = 9), hepatobiliary intervention (n = 4), post-laparoscopic cholecystectomy hepatic artery pseudoaneurysm (n = 3), hepatobiliary tumors (n = 3), and vascular malformation (n = 1). Melena, abdominal pain, hematemesis, and jaundice were the leading symptoms. All patients had undergone upper GI endoscopy, abdominal ultrasound, and computerized tomography of the abdomen. An angiogram and therapeutic embolization were done in 12 patients and was successful in nine but failed in three, requiring surgery. Surgical procedures performed were right hepatectomy (n = 4), extended right hepatectomy (n = 1), segmentectomy (n = 1), extended cholecystectomy (n = 1), repair of the pseudoaneurysm (n = 3), and right hepatic artery ligation (n = 1). CONCLUSION: The successful diagnosis of hemobilia depends on a high index of suspicion for patients with upper GI bleeding and biliary symptoms. Although transarterial embolization is the therapeutic option of choice for massive hemobilia, surgery has a definitive role in patients with hemodynamic instability, after failed embolization, and in patients requiring laparotomy for other reasons.
