Prevalence and trends of adult overweight and obesity in Nigeria - A systematic review and meta-analysis.

Background: The prevalence of obesity and its attendant complications are on the increase globally-sub-Saharan Africa inclusive. Obesity confers an increased risk of coronary artery disease, type 2 diabetes, ischemic stroke, and some cancers. In Nigeria, several individual reports estimate an exponential increase in the prevalence of overweight and obesity. Aim: In this study, we aimed to estimate the current prevalence of overweight and obesity in Nigeria through a systematic review and meta-analyses. Materials and Methods: A systematic review and meta-analysis were conducted on the prevalence of obesity in Nigeria using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) format following searches on major search engines, performed in PubMed, Science Direct, Google Scholar, Africa Journals Online (AJOL), and the WHO African Index Medicus database. Studies on the subject area conducted from the year 2000 to 2018 were included. The forest plot was used to graphically present the results, while confidence interval at 95% was used to display the rates. Results: A total of 77 articles on the prevalence of obesity involving 107, 781 individuals were used in the study. We found a pooled estimate of overweight of 26.0% (95% CI: 23.0-29.0) and that of obesity as 15.0% (95% CI: 13.0-16.0). There was an increasing trend in the prevalence of obesity in Nigeria from the study especially among urban dwellers. Conclusion: The prevalence of obesity and overweight in Nigeria is high with a rising trend over the years. A Nigerian national health survey of non-communicable diseases especially the burden of overweight/obesity is recommended to through more light on the subject. There is need for concerted effort to tame the tide of rising obesity rates in Nigeria.

The global burden of pulmonary hypertension in sickle cell disease: a systematic review and meta-analysis.

Elevated tricuspid regurgitant jet velocity (TRJV) is a surrogate measure of pulmonary hypertension (PH) in persons with sickle cell disease (SCD). We sought to estimate the burden of PH in people living with sickle cell disease based on TRJV. From 2000 to 2015, we searched electronic databases for eligible publications and included 29 studies (n = 5358 persons). We used random effects modeling to determine the pooled estimate of elevated TRJV. The overall pooled prevalence of elevated TRJV was 23.5 %(95 % CI 19.5-27.4) in persons with SCD. The pooled prevalence of elevated TRJV in children and adults with SCD was 20.7 % (95 % CI 15.7--25.6) and 24.4 % (95 % CI 18.4-30.4), respectively. TRJV is prevalent among adults and children with SCD. Our finding support international recommendations that call for screening for PH in SCD patients.

Prevalence of hepatitis B virus infection in Nigeria, 2000-2013: a systematic review and meta-analysis.

Vaccination against the hepatitis B virus (HBV) in the West African nation of Nigeria is lower than many Sub-Saharan African countries. In Nigeria, HBV is reported to be the most common cause of liver disease. However, the extent of HBV exposure among Nigerians at average risk is unknown. Our aim, therefore, was to accurately estimate the HBV prevalence for the country and the prevalence for specific subgroups. We used electronic databases to select systematic reviews and meta-analyses from 2000 to 2013. Forty-six studies were included (n = 34,376 persons). We used a random effects meta-analysis of cross-sectional and longitudinal studies to generate our estimates. The pooled prevalence of HBV in Nigeria was 13.6% (95% confidence interval [CI]: 11.5, 15.7%). The pooled prevalence (% [95% CI]) among subgroups was: 14.0% (11.7, 16.3) for blood donors; 14.1% (9.6, 18.6) for pregnant women attending antenatal clinics; 11.5% (6.0, 17.0) for children; 14.0% (11.6, 16.5) among adults; and 16.0% (11.1, 20.9) for studies evaluating adults and children. HBV prevalence in Nigeria varied by screening method [% (95% CI)]: 12.3% (10.1, 14.4) by using enzyme-linked immunosorbent assay; 17.5% (12.4, 22.7) by immunochromatography; and 13.6% (11.5, 15.7) by HBV DNA polymerase chain reaction. HBV infection is hyperendemic in Nigeria and may be the highest in Sub-Sahara Africa. Our results suggest that large numbers of pregnant women and children were exposed to HBV from 2000 to 2013. Increased efforts to prevent new HBV infections are urgently needed in Nigeria.

PREVALENCE OF METABOLIC SYNDROME AMONG APPARENTLY HEALTHY ADULTS IN A RURAL COMMUNITY, IN NORTH-WESTERN NIGERIA.

BACKGROUND: Metabolic syndrome (MetS) is a cluster of multiple metabolic abnormalities that increases the risk of cardiovascular morbidity and mortality, and a resultant severe economic implication. This study assessed the burden of MetS in a Nigerian rural community setting. METHOD: This was a cross-sectional, community based study on apparently healthy subjects. A multi stage cluster sampling technique was employed to recruit the study subjects. A standardized pre-tested questionnaire was used to obtain data, and blood samples from subjects were analysed using standard laboratory techniques. MetS was defined using the NCEP-ATP3 criteria. Data were analysed using STATA version II, and a p value of < 0.05 was considered statistically significant. RESULTS: A total of 450 subjects completed the study, with 38% being males, and a mean age of 40.27 ± 16.41 years. MetS was found in 116 (25.78%) of the subjects. Of these, systemic hypertension was found in 91(78.45%), while all (116) had elevated cholesterol and triglycerides. Abdominal adiposity was found in 45 (38.79%) subjects and 44 (37.93%) had Type 2 diabetes mellitus. CONCLUSION: The prevalence of MetS and its components in our studied population was high; hence the need for further large population based studies to determine its predictors in our environment.

Prevalence of Hepatitis B Virus Infection in Nigeria; 2000-2013: A Systematic Review and Meta-Analysis

Vaccination against the hepatitis B virus (HBV) in the West African nation of Nigeria is lower than many Sub-Saharan African countries. In Nigeria; HBV is reported to be the most common cause of liver disease. However; the extent of HBV exposure among Nigerians at average risk is unknown. Our aim; therefore; was to accurately estimate the HBV prevalence for the country and the prevalence for specific subgroups. We used electronic databases to select systematic reviews and meta-analyses from 2000 to 2013. Forty-six studies were included (n = 34;376 persons). We used a random effects meta-analysis of cross-sectional and longitudinal studies to generate our estimates. The pooled prevalence of HBV in Nigeria was 13.6 (95 confidence interval [CI]: 11.5; 15.7). The pooled prevalence ( [95 CI]) among subgroups was: 14.0 (11.7; 16.3) for blood donors; 14.1 (9.6; 18.6) for pregnant women attending antenatal clinics; 11.5 (6.0; 17.0) for children; 14.0 (11.6; 16.5) among adults; and 16.0 (11.1; 20.9) for studies evaluating adults and children. HBV prevalence in Nigeria varied by screening method [ (95 CI)]: 12.3 (10.1; 14.4) by using enzyme-linked immunosorbent assay; 17.5 (12.4; 22.7) by immunochromatography; and 13.6 (11.5; 15.7) by HBV DNA polymerase chain reaction. HBV infection is hyperendemic in Nigeria and may be the highest in Sub-Sahara Africa. Our results suggest that large numbers of pregnant women and children were exposed to HBV from 2000 to 2013. Increased efforts to prevent new HBV infections are urgently needed in Nigeria