[Effect of epithalamin on free-radical reactions in the formed elements of blood from breast cancer patients]. / Vliianie épitalamina na aktivnost' svobodnoradikal'nykh protsessov v formennykh élementakh krovi bol'nykh rakom molochnoi zhelezy.

Translocation of cytomedins into the cell is determined by their interaction with cellular membranes. The investigation concerned membrane-associated free-radical reactions in the formed elements of blood incubated with epithalamin. The antioxidative effect of epithalamin on such elements as red blood cells and lymphocytes sampled from breast cancer patients manifested itself as enhanced activity of antioxidative enzymes and elevated concentrations of fat-soluble antioxidative vitamins in the membranes. These changes are likely to be brought about by the intensification of their regeneration from the oxidized forms. It is suggested that the stimulating effect of epithalamin on immunocompetent cells is due to its modulating influence on free-radical reactions. This effect gives epithalamin significant advantage over many immunotropic drugs and makes a case for its large-scale application for immunological rehabilitation of cancer patients.

[Effect of homolymph on some elements of antioxidants in peripheral blood of lung cancer patients]. / Vliianie gomolimfy na nekotorye zven'ia antiokislitel'noi zashchity perifericheskoi krovi bol'nykh rakom lëgkogo.

The influence of homolymph and of that incubated with chemopreparations on in vitro activity of antioxidants of blood was compared to establish a possible mechanism of effective application of homolymphochemotherapy for locally advanced tumors of the lung. As a result of homolymph injection into the blood, mainly non-enzymatic systems of antioxidant defense by lymphocytes were affected. This was probably due to their being disposed of in the course of host-against-transplant reaction to heterogenous antigens of donor lymph. Neutrophil functional activity was shown to pick up again as homolymph and chemotherapeutic drugs interacted with blood. A possible therapeutic effect of homolymph and chemopreparations on blood may be alleviating lung tumor suppression of granulocytes.

[The effect of autolymph on peripheral blood antioxidants in lung cancer patients]. / Vliianie autolimfy na sistemu antiokislitel'noi zashchity perifericheskoi krovi bol'nykh rakom legkogo.

To establish the effect of autolymphochemotherapy on enzymatic and non-enzymatic systems of antioxidant protection of plasma and formed elements in blood of lung cancer patients, certain indices of peroxidation processes were simulated using a model containing blood and autolymph (with chemopreparations) sampled from patients with lung tumors. Autolymph injection into the patients' blood stream was followed on the basis moderate stress reaction which of caused reactions of endogenous antioxidants to oscillate. However, the structure and function of cellular membranes of formed elements were not affected. Chemotherapy neither aggravated stress condition nor did it exert direct cytotoxic effect on blood cells.

[The effect of chemotherapeutic drugs on free-radical oxidation of lipids in the lymph of lung cancer patients]. / Vliianie khimiopreparatov na protsessy svobodno-radikal'nogo okisleniia lipidov v limfe bol'nykh rakom lëgkogo.

Indices of lipid peroxidation in lymph from lung cancer patients before and after chemotherapy were studied. Chemotherapeutic drugs were shown to exert a moderate stressor effect on lymph by triggering oscillating reactions of endogenous antioxidant systems. Stress releases a pool of low-molecular weight antioxidants. Absence of catalase activity in plasma and lymphocytes is a peculiar feature of lymph in lung cancer patients.