[Improvement of pharmacological and surgical methods and techniques for the treatment of varicose disease]. / Sovershenstvovanie farmakokhirurgicheskikh metodov i tekhnicheskikh sredstv lecheniia varikoznoi bolezni.

Information about a surgical treatment of the varicose disease, its description, and the results of practical application, specific features, used drugs and technical appliances is reported. The remote results are indicative of a sufficiently high efficacy of the offered method.

[Clinical efficacy of using ximedon in surgical practice]. / Klinicheskaia éffektivnost' primeneniia ksimedona v khirurgicheskoi praktike.

Results of clinical trial of the new pyrimidine derivative--ximedone are presented. The drug was administered per os 0.5 g x 4 times a day (0.5 h before meals). Total course dose achieved 60 g. Ximedone implementation for complex treatment of burns, trophic ulcer of lower limbs, different inflammations demonstrated positive results. Prophylaxy administration of the drug in abdominal surgery at acute appendix resulted with lower incidence of postoperative complications. High efficacy and good tolerability of the drug allows to recommend it for wide medical use.

[Optimization of methods and improvement of technical means in combination with the nonspecific reparative regeneration stimulator ximedone in dermatoplasty surgery]. / Optimizatsiia metodov i sovershenstvovanie tekhnicheskikh sredstv v sochetanii s nespetsificheskim stimuliatorom reparativnoi regeneratsii ksimedon v kozhno-plasticheskoi khirurgii.

Treatment of extensive tissue defects should be complex, whose basis is an early free skin plastic repair with obligatory addition of agents that enhance the reparative capacities of tissues. For this, the authors propose a number of original appliances (forceps, variants of dermoperforators, bandage, etc.) and drugs, such as ximedon (tablets, 5-10% aqueous solution, lanolin-vaseline-based ointment, talc-based powder), whose clinical trials in 300 patients have shown their high therapeutical effect. The time of preparation of the wound surface for dermatoplastic interventions became shorter and the frequency of poor outcomes of operations reduced.

[A preclinical study of ximedone]. / Dolkinicheskoe issledovanie ksimedona.

Pharmacotoxicological properties of ximedone, a new pyrimidine derivative, were studied experimentally on animals of various species. In the enteral regimen the drug had a favourable effect on thermal burns and postoperative cutaneous and gastric wounds. The results enabled to recommend ximedone for the clinical practice.

[Adaptation-reposition technological means in combination with a bioactive preparation Ximedon for stimulation of wound healing]. / Adaptatsionno-repozitsionnye tekhnicheskie sredstva v sochetanii s bioaktivnym farmakologicheskim preparatom ksimedon dlia stimuliatsii zazhivleniia ran.

The paper proposes a working classification of devices for intra- and extrafocal transtissue vulnosynthesis with the concurrent use of the agents that enhance reparative regeneration. Evaluating wound closure with wound adapters or routine suture has shown the advantages of the techniques by employing the proposed devices: the latter accelerates and facilitates suture application reparative, increases atraumaticity, asepticity, creates conditions for forming a precision suture. The positive results of experimental studies and clinical observations suggest that wound adapters have promises in practical application, transtissue device-aided vulnosynthesis in combination with topical pyrimidine derivatives, such as ximedon, shows great opportunities in soft tissue lesions.