1.
Angew Chem Int Ed Engl
; 37(6): 812-814, 1998 Apr 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29711373
RESUMO
Transition state analogues of the peptide hydrolysis intermediate can take the form of complex silanediols such as 1, which inhibits angiotensin-converting enzyme (ACE) at nanomolar concentrations. In contrast, earlier investigation of enzyme inhibition with simple silanediols and silanetriols showed them to be inactive.