1.
Nucleosides Nucleotides Nucleic Acids
; 20(4-7): 533-8, 2001.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11563070
RESUMO
Colloidal silica particles were deposited on a glass substrate to produce high-capacity porous supports for high-density DNA probe arrays. Porous surfaces were used to increase the addressable surface area and number of probes available for hybridization. Surfaces derived from 70-100 nm size particles deposited in films from 0.15 to 2 microns thick exhibited excellent performance in light-directed oligonucleotide synthesis. Evaluation of these substrates in a genotyping assay is reported.