[The dynamics of the kallikrein-kinin system indices in patients with eczema vera during treatment by the laser photophoresis method with ortofen]. / Dinamika pokazatelei kallikrein-kininovoi sistemy u bol'nykh istinnoi ékzemoi v protsesse lecheniia metodom lazernogo fotoforeza s ortofenom.

A drastic increase (by 30.6 times) vs. the norm) of kallikrein activity was revealed in 70 patients with true eczema during exacerbation; blood plasma amidase activity was elevated 4.4-fold, serum alpha 2 macroglobulin antiprotease activity 1.4-fold. Laser photophoresis combined with application of a new Soviet nonsteroid anti-inflammatory agent orthofen reduced the parameters of the kallikrein-kinin system, and a tendency to their normalization could be observed.

[Use of the ethanol test in the diagnosis of occupational diseases and alcoholism]. / Ispo'lzovanie étanolovogo testa v diagnostike profzabolevanii i alkogolizma.

Pharmacokinetic indices of blood absorption of ethanol test-dose of 0.2 g/kg of the body weight from the gastrointestinal tract were distinctly lower among the workers exposed to organic solvents or lead, compared to the control group. Ethanol absorption constant was always significantly higher in patients with chronic alcoholism exposed to industrial toxic substances than in those having no contact with them.

[Interrelation of delta-aminolevulinic acid and brain myelin proteins as affected by benzene and lead]. / Izuchenie vzaimosviazi del'ta-aminolevulinovoi kisloty s belkami mielina golovnogo mozga pri deistvii benzola i svintsa na organizm.

An experimental model of subacute lead and benzene intoxication was induced in rabbits. It increased significantly delta-aminolevulinic acid (14C-ALA) incorporation into CNS myelin. ALA stably fixes on myelin proteins, especially Wolfgram proteins. In spite of this about one half of ALA incorporated into myelin linked with its basic proteins. Lead and benzene intoxication cause changes in the proportion of the basic fractions of myelin proteins. The amount of basic proteins increases, while the amount of proteolipid and Wolfgram proteins decreases. Lead and especially benzene intoxication decreases exogenous ALA insertion into basic proteins and proteolipid proteins, with ALA fixation on Wolfgram proteins remaining unchanged.

[Binding of delta-aminolevulinic acid by myelin proteins]. / Sviazyvanie del'ta-aminolevulinovoi kisloty belkami mielina.

Delta-[14C]aminolevulinic acid (ALA) was injected intracranially into experimental animals; the gray and white matter was obtained from the brain 24 hours thereafter. The radioactive label content in the ALA, protoporphyrin, microsomes, mitochondria, cell membranes and myelin was determined; no radioactivity was detected in ALA and protoporphyrin. The radioactive label was localized in the subcellular fractions and myelin, in particular, in the white matter. Analysis of protein myelin fractions demonstrated that ALA was incorporated into practically all basic proteins. The highest capacity to bind ALA was observed in case of Wolfgram proteins; however, almost half of the bound ALA in the myelin fraction was found within the composition of basic proteins. It was assumed that the binding of ALA to proteins occurs via the amide, carboxylic and keto groups of ALA.