RESUMO
@#BACKGROUND Insulin resistance is the state of organs being resistant to insulin resulting in decrease of glucose utility. Insulin resistance is tightly interconnected to metabolic syndrome and cardiovascular disease risk factors. However, among Mongolian population, study on insulin resistance is rare. METHODS The aim of the study was to evaluate the prevalence of insulin resistance (IR) and its relationships with cardiometabolic risk factors in middle aged Mongolians. In 149 men and women we measured carbohydrate and lipid metabolism parameters, obesity markers, blood pressure, high sensitive C-reactive protein and uric acid levels. IR was determined by the HOMA-IR index. The threshold level of HOMA-IR proved to be 2.8 conv. units. The frequency of IR detection by HOMA-IR index was 43.0%. We identified risk factors that were most closely associated with the presence of IR. They were metabolic syndrome by International Diabetes Federation (2005) criteria, diastolic blood pressure and C-reactive protein level. RESULTS Study covered 149 men and women with average age of 49.5. HOMA-IR index average was 2.2. The threshold HOMA-IR index was 2.8. The IR prevalence was high at 43% without any gender difference. CONCLUSION The threshold HOMA-IR index was 2.8 in the study participants. Moreover, cardiovascular risk factors according to SCORE criteria were high. High blood pressure, C-reactive protein, and having metabolic syndrome increases IR risk by 2-3 times. As a result of the study, diagnosing obesity using WHO criteria of BMI>30kg/m2 rather than WPRO criteria of BMI>25 kg/m2 is statistically more significant.
RESUMO
Introduction: A clustering of insulin resistance, hypertension and dyslipidemia has been labeled as the metabolic syndrome by the World Health Organizations and it often develops into type 2 diabetes with premature cardiovascular disease, resulting in an increasingly heavy burden on health care systems and general decrease in quality of life[10]. Asians have a lower frequency of obesity than Caucasians, but have an increasing tendency toward metabolic syndrome [11]. Most data on MS are based on studies from Western countries with only limited information derived from Asians populations. Aim. To compare application of the metabolic syndrome (MS) 3 definitions, proposed by International Diabetes Federation (IDF) in 2005[7], Adult Treatment Panel III (NCEP-ATPIII) in 2004[8], and VNOK in 2009[4], for railways workers in MongoliaMaterials and Methods. Weare conducted study of individuals aged 18-63 years in workplace settings in 7 cities Mongolia. We are selected a total of 1272 workers of railways company in Mongolia. (737 men and 540 women) We analyzed the health data for MS based Third Report of the National Cholesterol Educational Program Expert Panel on Detection, evaluation and Treatment of high blood cholesterol in adults (ATPIII)definition, and 2 definitions by IDF(2005) and VNOK(2009) Subjects were seemed to have metabolic syndrome if they had three or more of the following 5 criteria;1.visceral obesity, waist circumference ≥ 90 cm for men, ≥80 cm for women 2.hypertriglyceridemia, ≥150 mg/dl 3.Low HDL-C, < 40mg/dl for men and,<50md/dl for women 4 high blood pressure, ≥130/85 mm Hg;and 5. High fasting glucose ≥110 mg/dl.Results. To study metabolic syndrome (MS) and its components prevalence in urban population of men and women 20–63 years old the representative sample of 1272 central and 6 citizens (737men and 540 women) has been investigated during the period from 2011 till 2012. Prevalence of MS according to NCEP-ATPIII, 2004 criteria was 27.7 % (31.3% in men and 25.1% in women). Maximum prevalence was registered according to IDF (2005) criteria- 35.8 % (35.4% in men, 36.1% in women). VNOK (2009) criteria–30.3 % (31.7% and 29.3% respectively). Subjects with high fasting glucose levels (≥5,6mmol/l) have 25.4%Conclusions. As survey indicates Metabolic syndrome is increasingly observed in elderly people, with 50,1% in the people aged 50 and over. Maximum prevalence was registered according to IDF (2005) criteria-35,8%.3 or more criteria was -47,3%.
