Differentiating prospective control information for catching in at-risk and control adolescents.

This paper investigated the use of prospective control in catching and how the results can be used as a sensitive tool to detect diffuse signs of brain dysfunction. A detailed analysis of 286 catching movements of eight adolescents (two males, six females [four very-low-birth weight {VLBW}, one small for gestational age {SGA}, and three appropriate for gestational age]; mean age 14 y 5 mo [SD 6 mo]; range 14-15 y) was performed blind for this purpose. The moving target approached the participants from the side at three different, non-constant accelerations. The results showed that three adolescents used less advanced timing strategies that involved the lower-order variables of distance or velocity to govern movement initiation of at least one of their hands. Two of these were preterm VLBW and one was term SGA. The remaining adolescents, on the other hand, all relied on the higher-order variable of time-to-contact to initiate their hand movements, and were, therefore, considered low-risk. These results were compared with the cerebral magnetic resonance imaging results of the adolescents. The findings show that timing strategy pinpoints successfully those adolescents at risk of neurological problems. It was, therefore, concluded that the skill of using prospective information for catching can be used as a tool to detect diffuse signs of motor dysfunction, which are not readily detected by standard behavioural tests alone.

Cerebral metabolite differences in adolescents with low birth weight: assessment with in vivo proton MR spectroscopy.

BACKGROUND: Children with very low birth weight (VLBW) have a significantly increased risk of later neurodevelopmental problems, while infants born small for gestational age (SGA) at term are also at some risk of developing neurological impairment. OBJECTIVE: To investigate possible brain metabolite differences in adolescents with VLBW, SGA at term and controls by proton in vivo magnetic resonance spectroscopy (MRS) at 1.5 T. MATERIALS AND METHODS: MR spectra were acquired from volumes localized in the left frontal lobe, containing mainly white matter (54 subjects). Peak areas of N-acetyl aspartate (NAA), choline (Cho) and creatine (Cr) were determined, and the peak area ratio of NAA to Cr, total Cho to Cr, or NAA to Cho calculated. Probabilistic neural network (PNN) analysis was performed utilizing the chemical shift region containing resonances from NAA, Cho and Cr as inputs. RESULTS: No significant difference in the peak area ratios could be found using the Kruskal-Wallis test. By application of PNN, a correct classification of 52 of the 54 adolescents with a sensitivity and specificity exceeding 93% for all groups was achieved. CONCLUSION: Small, yet systematic, differences in brain metabolite distribution among the groups were confirmed by PNN analysis.

Low-birth-weight adolescents: psychiatric symptoms and cerebral MRI abnormalities.

To explore associations between psychiatric symptoms and cerebral magnetic resonance imaging abnormalities in low-birth-weight adolescents, 55 very low-birth-weight (or=10th centile) were assessed at 14-15 years of age. Outcome measures were Schedule for Affective Disorders and Schizophrenia for School-Age Children, Attention-Deficit/Hyperactivity Disorder Rating Scale IV, Autism Spectrum Screening Questionnaire, and qualitatively assessed cerebral magnetic resonance images. The very low-birth-weight group manifested increased prevalence of psychiatric symptoms and disorders compared with controls (P < 0.001), especially symptoms of attention-deficit/hyperactivity disorder, and high frequency of ventricular dilatation, white matter reduction, thinning of corpus callosum, and gliosis (P < 0.01 vs controls). The Attention-Deficit/Hyperactivity Disorder Rating Scale score was significantly associated with white matter reduction and thinning of corpus callosum in this group. The term small for gestational age group had increased prevalence of psychiatric symptoms compared with control subjects, but not more frequent abnormalities on cerebral magnetic resonance imaging. In conclusion, attention-deficit/hyperactivity disorder symptoms were significantly associated with white matter reduction and thinning of corpus callosum in very low-birth-weight adolescents. No associations were found for other psychiatric symptoms and brain abnormalities in any of the groups.