Assuntos
Autoanticorpos/imunologia , Teste de Histocompatibilidade , Transplante de Rim , Adulto , Linfócitos B/imunologia , Criança , Reações Falso-Positivas , Feminino , Antígenos HLA/imunologia , Humanos , Falência Renal Crônica/imunologia , Masculino , Linfócitos T/imunologia , Tuberculose Renal/genética , Tuberculose Renal/imunologiaAssuntos
Especificidade de Anticorpos , Antígenos HLA , Computadores , Reações Cruzadas , Humanos , MétodosRESUMO
The predictability of leucocyte typing in kidney transplantation was assessed by an analysis of 37 kidney transplants from sibling donors. Recipients who were identical for the HL-A antigens with their donors gave highly predictable results. In comparison with those siblings who were incompatible or compatible but not identical their grafts functioned earlier, they required less immunosuppression, and had never had any rejections. They also appeared to have less postoperative morbidity. These results indicate that less immunosuppression than is current in many transplant centres could well be used with benefit in HL-A identical sibling transplants. This could reduce the risk of infection and possibly minimize the adverse effects of steroids on wound healing in these patients.
