[The effect of the preparation Wobe-Mugos E on the functional and biochemical status of the kidneys in the polyuric stage of sublimate-induced nephropathy]. / Vplyv preparatu Wobe-Mugos E na funktsional'nyi ta biokhimichnyi stan nyrok u poliurychnu stadiiu sulemovoï nefropatiï.

The protective effect of Wobe-Mugos appliance on the kidney function and biochemical state in polyuric stage of sublimate nephropathia at the moment of tubulointerstitial component formation was revealed in experiments on 40 white male rats. It appeared in the increase of hydrogenous ion excretion, titred acids, renal tissue fibrinolytic and proteolytic activity. The succinatdehydrogenase activation in renal cortex matter pointed out on the improvement of energy balance.

[The mechanisms of the GABA-ergic regulation of beta-endorphin levels in the hypothalamic structures of prenatally stressed male rats]. / Mekhanizmy HAMK-erhichnoï rehuliatsi rivniv beta-endorfinu v strukturakh hipotalamusa prenatal'no stressovanykh samtsiv shchuriv.

The effect of GABA receptors agonists on the stress-induced beta-endorphin levels in the preoptic area and mediobasal hypothalamus of the intact and prenatally stressed male albino rats was studied. It has been found out that stimulation of GABAa-receptor complex by means of the muscimol leads to increasing of beta-endorphin levels in the preoptic area and mediobasal hypothalamus of the control animals. GABAb receptor activation by means of the baclofen decreases opioids level in the mediobasal hypothalamus. Prenatal stress eliminates stimulant effect of the muscimol on beta-endorphin levels in the investigated brain structures and leads to the opioid level decreasing after baclofen influence in preoptic area.

[Pathological changes in thrombocyte-vascular and coagulative hemostasis under the influence of lead chloride and their correction by using a synthetic analog of prostacyclin]. / Patolohichni zminy trombotsytarno-sudynnoho ta koahukiatsiinoho hemostazu pid vplyvom khlorystoho svintsiu ta ïkh korektsiia za dopomohoiu syntetychnoho analoha prostatsyklinu.

It has been established that plumbum chloride possesses a marked toxic action on the membranes of the formed elements, in particular, the thrombocytes, activates the release of the factors of thrombocyte aggregations, resulting in an increase of their adhesive and aggregation properties. The research studies the influence of the stable prostacycline analogue MM-706 and thrombocytic-vascular, as well as coagulative hemostasis in rats at a background of plumbum intoxication. We have discovered a marked protective action of MM-706 on the thrombocytes which is manifested through a decrease of the index of a spontaneous thrombocyte aggregation and percentage of adhesive thrombocytes, normalization of the general potential of hemocoagulation and time characteristics of a thromboelastogram.