Assuntos
Injúria Renal Aguda/induzido quimicamente , Adenocarcinoma/tratamento farmacológico , Antineoplásicos/efeitos adversos , Compostos Organoplatínicos/efeitos adversos , Neoplasias Ovarianas/tratamento farmacológico , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica , Feminino , Humanos , Necrose Tubular Aguda/induzido quimicamente , Necrose Tubular Aguda/patologia , Compostos Organoplatínicos/administração & dosagem , OxaliplatinaAssuntos
Corticosteroides/uso terapêutico , Pneumonia em Organização Criptogênica/tratamento farmacológico , Pancreatite/tratamento farmacológico , Prednisona/uso terapêutico , Fibrose Retroperitoneal/tratamento farmacológico , Adulto , Pneumonia em Organização Criptogênica/patologia , Humanos , Masculino , Pancreatite/patologia , Indução de Remissão , Fibrose Retroperitoneal/patologia , Esclerose/tratamento farmacológico , Resultado do TratamentoRESUMO
DEFINITION OF HYPOURICEMIA: Hypouricemia (serum uric acid less than 120 micro mol/l) is a biological abnormality often discovered accidentally and with a low prevalence depending on its permanent or transitory nature ranging from 0.15 to 3.38%. NEW PHYSIOLOGICAL CONCEPTS OF ITS PATHOGENESIS: Recently, our knowledge of the physiopathological mechanisms of hypouricemia has been emphasized by the identification of three systems of renal and extra-renal uric acid transport: a Cl/urate (URAT1) transporter, a multispecific organic anion transporter (OAT) and a urate transporter/channel. ETIOLOGY AND COMPLICATIONS OF HYPOURICEMIA: Through questioning, drugs and toxics (allopurinol.) are generally rapidly recognized as responsible for half of the hypouricemia encountered. It can be concomitant to a known disease: severe liver disease, neoplasia, diabetes, AIDS, syndrome of inappropriate antidiuretic hormone secretion. Hypouricemia can also be isolated and justifies the measurement of uric acid clearance, the normality or reduction of which orients towards a deficiency in xanthine-oxydase, the increase in which suggests an abnormality in uric acid transport in the proximal tubule (Fanconi syndrome, primary hereditary anomaly of tubular uric acid transport). Hypouricemia does not appear to expose the patient to any danger, but the onset of nephrolithiasis or acute renal failure secondary to the combination of severe hypouricemia and oxidant stress is always possible.
Assuntos
Proteínas de Transporte/genética , Túbulos Renais Proximais/fisiologia , Proteínas Associadas à Resistência a Múltiplos Medicamentos/genética , Transportadores de Ânions Orgânicos/genética , Ácido Úrico/sangue , Proteínas de Transporte/fisiologia , Humanos , Proteínas Associadas à Resistência a Múltiplos Medicamentos/fisiologia , Transportadores de Ânions Orgânicos/fisiologia , Proteínas de Transporte de Cátions Orgânicos , Prevalência , Insuficiência Renal/etiologia , Ácido Úrico/metabolismoRESUMO
We report the case of a patient with predominantly renal sarcoidosis. Renal failure responded well to systemic corticosteroid therapy. The clinical presentation was particular, notably the absence of lung involvement and the presence of cutaneous lymphedema.