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Biochim Biophys Acta ; 1852(6): 1124-36, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25583116

RESUMO

Throughout the Western world obesity prevalence is steadily increasing, and associated metabolic co-morbidities are projected to rise during the years to come. As weight loss and weight maintenance remains a major problem, new strategies to protect against obesity-related morbidity are needed. There is a clear association between obesity, low-grade inflammation and obesity-associated diseases, thus, the development of new anti-inflammatory substances is urgently needed as these may ultimately pave the way for novel treatments of obesity and lifestyle-related diseases. A candidate molecule is the polyphenolic compound resveratrol, and in the present review, we provide an overview of the field, and discuss the future scientific perspectives. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.


Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Obesidade/tratamento farmacológico , Estilbenos/uso terapêutico , Tecido Adiposo/efeitos dos fármacos , Tecido Adiposo/metabolismo , Animais , Anti-Inflamatórios não Esteroides/farmacologia , Ensaios Clínicos como Assunto , Humanos , Inflamação/tratamento farmacológico , Resveratrol , Estilbenos/farmacologia , Pesquisa Translacional Biomédica
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