[Assessment of the concentrations of carbonylated proteins and carbonyl reductase enzyme in mexican women with breast cancer: A pilot study]. / Determinación de proteínas carboniladas y enzima carbonil reductasa en mujeres mexicanas con cáncer de mama: estudio piloto.

Oxidative stress could promote the development of cancer and implicate carbonylated proteins in the carcinogenic process. The goal of this study was to assess the concentrations of carbonylated proteins and carbonyl reductase enzyme in women with breast cancer and determine whether these markers were possible indicators of tissue damage caused by the disease. A total of 120 healthy women and 123 women with a diagnosis of breast cancer were included. The concentration of carbonylated proteins in plasma and the concentration of carbonyl reductase enzyme in leukocytes were determined using the ELISA assay. There was a 3.76-fold increase in the amount of carbonylated proteins in the plasma from the patient group compared with healthy control group (5±3.27 vs. 1.33±2.31 nmol carbonyls/mg protein; p<0.05). Additionally, a 60% increase in the carbonyl reductase enzyme was observed in the patient group compared with the healthy control group (3.27±0.124 vs. 2.04±0.11 ng/mg protein; p<0.05). A positive correlation (r=0.95; p<0.001) was found between both measurements. These results suggest the presence of tissue damage produced by cancer; therefore, these parameters could be used to indicate tissue damage in cancer patients.

[May-Thurner syndrome as a cause of neurovascular compression of the pudendal nerve]. / Síndrome de May-Thurner como causa de compresión neurovascular del nervio pudendo.

May-Thurner syndrome is a clinical condition that results from narrowing of the left common iliac vein lumen due to pressure from the right common iliac artery as it crosses anterior to it. We describe an atypical case of May-Thurner syndrome in a 23-year-old woman that presented only continuous pain in pudendal zone without vascular symptoms. The Doppler ultrasound, nuclear magnetic resonance and others complementary analyses show the presence of a pelvic venous congestion syndrome and we hypothesized that this condition produced a neuropathic compression of the pudendal nerve in Alcock's canal. Patient was treated with the technique of pudendal nerve blockade by trans-gluteal via. An important reduction in pain of pudendal zone was showed.