RESUMO
Diabetic mastopathy is an uncommon, benign breast lesion that is typically seen in patients with type 1 diabetes mellitus (T1DM). The main differential diagnosis for diabetic mastopathy is breast carcinoma, which appears similarly on clinical examination and diagnostic imaging. Although the etiology of diabetic mastopathy is poorly understood, it has been associated with several autoimmune conditions, such as Hashimoto's thyroiditis, systemic lupus erythematosus, and Sjogren's syndrome. Here, we report a case of diabetic mastopathy in a T1DM patient with an associated history of elevated thyroid peroxidase (TPO) and antimitochondrial antibody (AMA) levels, giving further support to the theory of autoimmune etiopathogenesis.
RESUMO
Extramedullary myeloid sarcoma (MS) of the breast is a rare disease, representing 0.12% of all diagnoses of acute myeloid leukemia. We review a case of a 27-year-old female who presented with a palpable right breast mass. She subsequently underwent a biopsy, which showed breast tissue with diffuse infiltrate of blasts compatible with MS. A bone marrow biopsy was performed with no evidence of leukemia or lymphoma. Therefore, a second breast biopsy was obtained for additional testing and cytogenetics which demonstrated positive (t8;21)(q22;q22) translocation associated with acute myeloid leukemia. Patient was admitted for induction of chemotherapy, but she subsequently developed neutropenic colitis and C. diff colitis. Unfortunately, her condition quickly deteriorated, and she passed away shortly after. This report aims to describe the clinical, radiographic, and pathological features of a case of extramedullary MS involving the breast.
