Nonchemical integration of Au/Ag-based reduced graphene nanohybrid combined with 5-Fluorouracil drug to treat cancer cells.

The perpetual lack of advanced strategies to prevent aggressive breast cancer with multiple categories represents challenging scientific society problems. Reduced graphene oxide- can treat disease, which was recently investigated due to its ability to induce apoptosis-based death. This research tested the chemotherapeutics in vitro efficacy of reduced graphene oxide embedded with gold and silver nanoparticles toward drug-sensitive breast cancer cells (MCF-7) and their cytotoxicity. Synthesis of the Au-Ag/rGO-5FU nanocomposites has been conducted using a wet chemical approach with chitosan aid as a pore directing and capping agent. The particle structure and morphology well characterized using different systems. HR-TEM shows a narrow-sized distribution of less than 100 nm, which is proper for cell membranes and medical use. The physical combination of the nanocomposite and 5-FU drug has been conducted mechanically using wet chemistry. The Au/Ag/rGO-5FU material's high activity enables it to produce reactive oxygen radicals, which display a potential against MCF-7 cell lines. All the results, including those obtained via cytometry, use the combination of Au/Ag/rGO-5FU to show a more substantial anticancer influence and more drug stability than pure 5-FU.

A graphene gold nanocomposite-based 5-FU drug and the enhancement of the MCF-7 cell line treatment.

There is no doubt that cancer is now one of the most formidable diseases in the world; despite all the efforts and research, common treatment routes, including chemotherapy, photodynamic therapy, and photothermal therapy, suffer from different limitations in terms of their efficiency and performance. For this reason, different strategies are being explored to improve the efficiency of the traditional drugs reported to date. In this study, we have redirected the function of one of these drugs (5-fluorouracil, 5-FU) by combining it with a graphene-gold nanocomposite in different molar ratios that has been exceedingly used for biological research development. The high activity of the graphene-gold material enables it to produce reactive oxygen and ions, which display good anticancer and antioxidant activity through the scavenging of the DPPH, SOD and GP x radicals; in addition, different characterizations have been used to confirm the structure and morphology of the obtained samples. Highly potent cytotoxicity against the MCF-7 cells was achieved with the drug combination containing the nanocomposite. All the results, including those obtained via cytometry, indicate that the combination of 5% graphene-gold nanocomposites with 5-FU exhibits a higher antitumor impact and more drug stability than pure 5-FU.