[Kinetics of DNA reparative replication in the spleen cells of CBA- and C57BL/6-strain mice induced by urethane and and the influenza virus]. / Kinetika reparativnoi replikatsii DNK kletok selezenki myshei linii CBA i C57BL/6, inutsirovannoi uretanom i virusom grippa.

Different kinetics of DNA repair replication induced by urethan and influenza virus was detected in mice of varying genotypes. Inhibition of repair replication was detected in the lymphocytes of C57BL/6 mice, infected with influenza virus and treated with urethan. No inhibition of repair replication was noted in CBA mice which is characteristic of resistance to influenza virus. However, stimulation of repair replication by influenza virus was observed in these cells.

[Study of the effect of parotitis vaccine on DNA repair in human lymphocytes]. / Izuchenie vliianiia parotitnoi vaktsiny na reparativnyi sintez DNK vlimfotsitakh cheloveka.

The effect of parotitis vaccine virus (strain L-3) on the DNA repair synthesis induced by 4-nitroquinoline-1-oxide has been studied. The efficiency of the repair synthesis depends on individual properties of the human body, viral multiplicity and concentration of the mutagen. A two-fold increase in DNA repair synthesis was obtained after infection of cells with low viral multiplicity (0.001 HADU50 per cell) and using 2.5 x 10(-7) M concentration of the mutagen A ten-fold increase in mutagen concentration affecting the infected cells was accompanied by the inhibition of DNA repair synthesis. Lymphocytes from children studied 7 days after vaccination by the attenuated virus did not reveal any changes in DNA repair synthesis as compared with the cells from nonvaccinated children.

[Regulation of the excisional repair system in in vitro-cultured human cells by measles viruses depending on their attenuation]. / Reguliatsiia ékstsizionnoi sistemy reparatsii v kletkakh cheloveka, kul'tiviruemykh in vitro, virusami kori v zavisimosti ot ikh attenuatsii.

The effect of measles viruses (attenuated strain L-16 and virulent strain Edmonston) was studied in human cells (line L-41) according to the criteria of repair: excision of thymine dimers, repair replication of DNA and resynthesis of DNA breaks induced by UV-irradiation. Reproduction of attenuated measles virus in cells was accompanied with stimulation of excision of thymine dimers and repair replication of DNA in contradistinction to mild virus. This phenomenon depended on multiplicity of infection.