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1.
J Adolesc Young Adult Oncol ; 11(2): 229-233, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-34143664

RESUMO

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has disrupted health care globally with dramatic impacts on cancer care delivery in addition to adverse economic and psychological effects. This study examined impacts of the SARS-CoV-2 pandemic on young adult colorectal cancer (CRC) survivors diagnosed age 18-39 years. Nearly 40% reported delays in cancer-related care, loss of income, and poorer mental health during the pandemic. Impacts were greater for survivors aged 20-29 years, with nearly 60% reporting cancer care delays and 53% experiencing income loss. Such impacts may result in detrimental downstream outcomes for young CRC survivors, requiring specific support, resources, and continued monitoring.


Assuntos
COVID-19 , Sobreviventes de Câncer , Neoplasias Colorretais , COVID-19/epidemiologia , Neoplasias Colorretais/epidemiologia , Humanos , Pandemias , SARS-CoV-2 , Adulto Jovem
2.
Am J Physiol Renal Physiol ; 315(3): F521-F534, 2018 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-29667908

RESUMO

The prorenin receptor (PRR) was originally proposed to be a member of the renin-angiotensin system (RAS); however, recent work questioned their association. The present paper describes a functional link between the PRR and RAS in the renal juxtaglomerular apparatus (JGA), a classic anatomical site of the RAS. PRR expression was found in the sensory cells of the JGA, the macula densa (MD), and immunohistochemistry-localized PRR to the MD basolateral cell membrane in mouse, rat, and human kidneys. MD cell PRR activation led to MAP kinase ERK1/2 signaling and stimulation of PGE2 release, the classic pathway of MD-mediated renin release. Exogenous renin or prorenin added to the in vitro microperfused JGA-induced acute renin release, which was inhibited by removing the MD or by the administration of a PRR decoy peptide. To test the function of MD PRR in vivo, we established a new mouse model with inducible conditional knockout (cKO) of the PRR in MD cells based on neural nitric oxide synthase-driven Cre-lox recombination. Deletion of the MD PRR significantly reduced blood pressure and plasma renin. Challenging the RAS by low-salt diet + captopril treatment caused further significant reductions in blood pressure, renal renin, cyclooxygenase-2, and microsomal PGE synthase expression in cKO vs. wild-type mice. These results suggest that the MD PRR is essential in a novel JGA short-loop feedback mechanism, which is integrated within the classic MD mechanism to control renin synthesis and release and to maintain blood pressure.


Assuntos
Pressão Sanguínea , Sistema Justaglomerular/enzimologia , ATPases Translocadoras de Prótons/metabolismo , Receptores de Superfície Celular/metabolismo , Sistema Renina-Angiotensina , Renina/metabolismo , ATPases Vacuolares Próton-Translocadoras/metabolismo , Inibidores da Enzima Conversora de Angiotensina/farmacologia , Animais , Técnicas Biossensoriais , Pressão Sanguínea/efeitos dos fármacos , Captopril/farmacologia , Ciclo-Oxigenase 2/metabolismo , Dieta Hipossódica , Dinoprostona/metabolismo , MAP Quinases Reguladas por Sinal Extracelular/metabolismo , Células HEK293 , Humanos , Sistema Justaglomerular/efeitos dos fármacos , Masculino , Camundongos Endogâmicos C57BL , Camundongos Knockout , Prostaglandina-E Sintases/metabolismo , ATPases Translocadoras de Prótons/deficiência , ATPases Translocadoras de Prótons/genética , Ratos Sprague-Dawley , Receptores de Superfície Celular/deficiência , Receptores de Superfície Celular/genética , Sistema Renina-Angiotensina/efeitos dos fármacos , Via Secretória , Transdução de Sinais , ATPases Vacuolares Próton-Translocadoras/genética , Receptor de Pró-Renina
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