[Biochemical characteristics of the brain mediator systems during stimulation of metastasis from surgical removal of a tumor]. / Viokhimicheskaia kharakteristika mediatornykh sistem golovnogo mozga v usloviiakh stimuliatsii metastazirovaniia pri khirurgicheskom udalenii opukholi.

In cases of tumor surgical operation, which stimulated metastatic spreading, distinct activation of hypothalamic structures was observed simultaneously with generalization of impairments in the neurotransmitting systems, accompanied by their exhaustion and disturbance. Pathology-related alterations in brain neurotransmitting reactions, provoked by surgical operation in cases of tumors, considerably exceeded similar parameters in non-operated or sham-operated animals.

[The effect of Leu- and Met-enkephalins on the adenosine deaminase and 5'-nucleotidase activities of the lymphocytes under conditions of stress stimulation of metastasis]. / Vliianie lei- i met-énkefalinov na aktivnost' adenozindezaminazy i 5'-nukleotidazy limfotsitov v usloviiakh stressornoi stimuliatsii metastazirovaniia.

A correlation between changes of the hypothalamic mediator processes, hormone level in blood plasma, catecholamines and their catabolites in urine and changes of the activity of adenosine metabolism enzymes in the thymus and the spleen lymphocytes has been observed in C57B1 mice with Lewis lung carcinoma. Effect of leu- and met-enkephalines on neuroendocrine stress-realizing mechanisms proved to be different, that is responsible for their contrary effect on the metastatic growth--leu-enkephaline inhibits and met-enkephaline stimulates the process. It has been shown that an inhibitory effect of leu-enkephaline is greatly related to its stimulating influence on the thymus lymphocyte activity and a decrease of the functional activity of the spleen lymphocytes.

[Effects of constant magnetic field on the growth and metastasizing of Lewis carcinoma in mice]. / Vliianie postoiannogo magnitnogo polia na rost i metastazirovanie kartsinomy L'iuis u myshei.

In mice with the metastasizing Lewis carcinoma the constant magnetic field (CMF) was studied for its effect on growth and metastatic process depending on the immobilization of animals. The results obtained show a decrease in the rate of the primary tumour growth and in the intensity of the metastatic process under the influence of CMF by incomplete immobilization. Complete immobilization eliminates the antimetastatic effects of the CMF.

[Endothelial changes in the pulmonary blood vessels of mice with Lewis lung carcinoma and experimental stress]. / Izmeneniia éndoteliia krovenosnykh sosudov legkogo myshei s kartsinomoi legkogo L'iuis pri éksperimental'nom stresse.

The influence of surgical tumour removal and of the emotional-pain stress described by Desiderato on the lung metastases development and lung vascular internal surface state was studied in C57BL mice with Lewis carcinoma. Scanning electron microscopy revealed a stress-damaging effect on vascular walls. It is possible to assume that the stress damage of pulmonary blood vessels greatly influences the stimulation of metastases. Concrete mechanisms responsible for this phenomenon are elucidated.

[Mediator processes in the hypothalamus in the development of Lewis pulmonary carcinoma]. / Mediatornye protsessy v gipotalamuse pri razvitii kartsinomy legkikh L'iuis.

The phase changes of biochemical characteristics of hypothalamic mediator systems have been demonstrated in C57Bl mice with Lewis carcinoma. Phase I generated due to implantation of tumour cells was characterized by predominant exciting processes, which can increase the dissemination and sedimentation of tumour cells. During phases II--a period of metastatic formation--the normalization was found in hypothalamic mediator systems, which along with the activation of serotoninergic mechanisms promotes the inhibition of antitumour resistance. Phase III was related to the acute activation of mediator exciting processes and weakening of inhibition processes. Stress reactions arising under these conditions can stimulate tumour cell extravasation and development, and active growth of early metastatic nodules. The depletion of exciting mediator systems of the hypothalamus followed by general exhaustion of the organism was observed in phase IV.