RESUMO
The cause of growth retardation seen in children with B-thalassaemia major is not fully understood. Neither the one-hour D-xylose absorption test nor jejunal biopsy support the suggestion of small bowel malabsorption as a contributory cause.
Assuntos
Talassemia/metabolismo , Xilose , Criança , Pré-Escolar , Feminino , Transtornos do Crescimento/etiologia , Humanos , Absorção Intestinal , Síndromes de Malabsorção/complicações , Síndromes de Malabsorção/etiologia , Masculino , Talassemia/complicaçõesRESUMO
Children with severe Trichuris trichiura infection pose significant social, clinical, and therapeutic problems in Malaysia. Thirty such children were investigated, and mebendazole was found to be safe and effective in the treatment of severe trichuriasis but it had to be given for a longer period than currently recommended. A poor correlation was found between egg load and worm burden in these children. Direct visualization of the rectal and colonic mucosa was the most reliable method of assessing severity in untreated cases, and response to treatment. The eggs of Trichuris that had been exposed to mebendazole were morphologically altered and not viable when incubated. This may be of considerable epidemiological importance.
