1.
Antimicrob Agents Chemother
; 54(1): 522-5, 2010 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19841143
RESUMO
Echinocandins have become the drug of choice in infections caused by Candida glabrata. The objective of this study was to evaluate the in vitro activity of caspofungin alone and in combination against C. glabrata. In vitro assays demonstrated that caspofungin alone showed excellent fungicidal activity against C. glabrata, including fluconazole-resistant strains. The combination of caspofungin and azole antifungals showed potential synergy against C. glabrata. Overall, caspofungin demonstrated excellent in vitro activity, alone and in combination, against strains of C. glabrata.
Assuntos
Antifúngicos/farmacologia , Candida glabrata/efeitos dos fármacos , Equinocandinas/farmacologia , Anfotericina B/farmacologia , Azóis/farmacologia , Caspofungina , Combinação de Medicamentos , Farmacorresistência Fúngica , Sinergismo Farmacológico , Fluconazol/farmacologia , Cinética , Lipopeptídeos , Testes de Sensibilidade Microbiana , Pirimidinas/farmacologia , Fatores de Tempo , Triazóis/farmacologia , Voriconazol
2.
N Engl J Med
; 341(4): 292-3, 1999 Jul 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10419394