RESUMO
The state of the proinflammatory cytokines tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6, and the anti-inflammatory cytokine IL-10 was studied in patients with bacterial quinsy over time. There were significant and heterodirectional changes in the plasma level of proinflammatory and anti-inflammatory cytokines with the normalization of their content in the period of late convalescence. The regular shifts of proinflammatory cytokines in patients with quinsy depended on the period and clinical forms of the disease, its severity, complications, comorbidity, and the plenitude of recovery. The paper discusses a role and implication of cytokines.
Assuntos
Infecções Bacterianas/sangue , Citocinas/sangue , Faringite/sangue , Infecções Bacterianas/complicações , Infecções Bacterianas/tratamento farmacológico , Feminino , Humanos , Interleucina-10/sangue , Interleucina-1beta/sangue , Masculino , Abscesso Peritonsilar/sangue , Abscesso Peritonsilar/tratamento farmacológico , Abscesso Peritonsilar/etiologia , Faringite/complicações , Faringite/tratamento farmacológico , Fator de Necrose Tumoral alfa/sangueRESUMO
Properties of prooxidative and antioxidative systems were investigated in 74 patients with bacterial sore throat. The results suggest a noticeable unidirectional change of the free radical status with marked amplification of prooxidative and attenuation of antioxidative activities depending on the clinical form of the disease, its severity, and the presence of concomitant pathologies.
Assuntos
Sequestradores de Radicais Livres/metabolismo , Peroxidação de Lipídeos/fisiologia , Faringite/metabolismo , Adolescente , Adulto , Feminino , Humanos , Masculino , Malondialdeído/metabolismo , Pessoa de Meia-Idade , Faringite/microbiologia , Mucosa Respiratória/metabolismo , Mucosa Respiratória/microbiologia , Índice de Gravidade de Doença , Adulto JovemRESUMO
The level of middle-mass molecule peptides (MMMP) of blood plasma was investigated in 98 patients with tonsillitis. A significant increase in the level of MMMP with a maximal rise at the height of the disease with normalization in early and late convalescence was revealed. The changes in plasma MMMP in tonsillitis depended on the clinical form, stage and severity of the disease, complications, concomitant diseases, completeness of convalescence. High therapeutic efficacy of an immunomodulating drug tamerit in combined therapy of patients with bacterial tonsillitis is shown.
