[Dynamic study of the development of edema in the organs in experimental burn trauma]. / Issledovanie dinamiki razvitiia oteka v organakh pri éksperimental'noi ozhogovoi travme.

Proton magnetic relaxation with measuring the time of spin-screen relaxation (T1) was used to study the time course of derangement of organ and tissue flooding after stage IIIB experimental burn of 15% body area. To examine the structures of the microcirculatory vessels, use was made of electron microscopy of the organs. The internal organs under study demonstrated a significant long-term (up to 49 days) increase in flooding: in the liver and kidneys, it occurred since the first day after burn, while in the lungs, myocardium and brain, since the 7th day. The results indicate the parallelism of the changes in the T1 and electron microscopic alterations in the histohematic barriers. Proton magnetic relaxation enables a more rapid and more convenient assay of the changes in tissue flooding as compared to the method of drying at high temperature. Therefore, it may be applied to the assessment of the efficacy of different therapeutic means.

[Use of the proton magnetic relaxation technic in the study of experimental burns]. / Ispol'zovanie metoda protonnoi magnitnoi relaksatsii v izuchenii éksperimental'nykh ozhogov.

Experiments with the use of proton magnetic relaxation have shown the presence of marked biophysical changes in the organs during deep skin burns with an area of 6% of the body surface. The method is highly responsive to the changes in tissue hydratation and is characterized by good reproducibility of the results. The technical simplicity of the method (5-10 minutes per sample) permits using proton magnetic relaxation on a large scale. The data obtained allow a conclusion that the method under consideration should be recommended for studying the status of water in experimental burns and in clinical trials.

Causes of the resistance of Chlorella strains to physical and chemical environmental factors.

Factors have been studied which are responsible for the resistance of cells of several strains of Chlorella to physical and chemical stresses; measurements have been made of the effects of UV and x irradiation, heat treatment, detergents, cadmium salts, and insecticides. Cells which were resistant to the effects of physical factors were also resistant to chemical intoxication. A positive correlation was found between the resistance of cells to the described factors and the level of endogenous thiols in the cells, as well as the free radical content. This in turn is due to an increased number of reaction centers in the electron-transport chain.