1.
Chem Commun (Camb)
; 57(5): 631-634, 2021 Jan 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33346276
RESUMO
Isocyanates are the key intermediates for several organic transformations towards the synthesis of diverse pharmaceutical targets. Herein, we report the development of an oxidant-free protocol for electrochemical in situ generation of isocyanates. This strategy highlights expedient access to benzimidazolones and quinazolinones and eliminates the need for exogenous oxidants. Furthermore, detailed mechanistic studies provide strong support towards our hypothesis of in situ isocyanate generation.