RESUMO
A decaffeinated green coffee bean extract (DGCBE) inhibited porcine pancreas lipase (PPL) activity with an IC50 value of 1.98 mg/mL. Six different chlorogenic acids in DGCBE contributed to this PPL inhibition, accounting for 91.8% of the inhibitory activity. DGCBE increased the droplet size and decreased the specific surface area of an olive oil emulsion.
Assuntos
Cafeína/isolamento & purificação , Ácido Clorogênico/farmacologia , Coffea/química , Lipase/antagonistas & inibidores , Pâncreas/enzimologia , Óleos de Plantas/química , Sementes/química , Animais , Biocatálise/efeitos dos fármacos , Emulsões , Inibidores Enzimáticos/farmacologia , Hidrólise/efeitos dos fármacos , Azeite de Oliva , SuínosRESUMO
Coffee "silverskin" (CS) is a by-product of the roasting procedure for coffee beans. A CS extract (CS-ext) was found to have a high inhibitory effect against hyaluronidase. It seems that the higher-molecular-weight substances in CS-ext contributed most to the hyaluronidase inhibition, while acidic polysaccharides mainly composed of uronic acid played a major role in this hyaluronidase inhibition by CS-ext.