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J Acquir Immune Defic Syndr ; 74(4): 454-458, 2017 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-28225719

RESUMO

Monocytes play a vital role in HIV-associated neurocognitive disorder (HAND), postulated to transport HIV into the brain and secrete pro-inflammatory cytokines. We analyzed cytokines released by cultured peripheral blood mononuclear cells enriched with the CD14 marker isolated from HIV-infected individuals with HAND and normal cognition (NC) in combination antiretroviral therapy naive and after 1 year on treatment. Interleukin-8 and monocyte chemoattractant protein-1 levels were higher in HAND compared with NC at baseline (P = 0.002 and P < 0.0001). These cytokines remained higher in HAND patients 1 year after combination antiretroviral therapy and were significant when NC patients who were initially HAND were excluded (P = 0.012 and P = 0.002). Both correlated with baseline CD14 peripheral blood mononuclear cell HIV DNA levels supporting the role of HIV DNA reservoir size and monocyte cytokines in HAND persistence.


Assuntos
Complexo AIDS Demência/metabolismo , Infecções por HIV/metabolismo , Leucócitos Mononucleares/metabolismo , Receptores de Lipopolissacarídeos/metabolismo , Complexo AIDS Demência/fisiopatologia , Citocinas , Perfilação da Expressão Gênica , Infecções por HIV/fisiopatologia , Humanos , Monócitos , Carga Viral
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