Anterior chamber inflammation after transconjunctival cryosurgery.

BACKGROUND: Inflammation caused by transconjunctival cryotherapy for prophylactic retinal detachment surgery was measured in various conditions. METHODS: Thirty-four eyes of 28 patients with peripheral retinal lesions predisposing to retinal detachment were studied by laser flare cell meter before and after treatment. RESULTS: The mean flare value for 34 eyes was 4.06 +/- 1.45 photon counts/ms before surgery and 5.72 +/- 2.52 pc/ms after surgery (p < 0.05). Flare value was elevated at 1, 2, and 3 weeks after treatment, peaking at 2 weeks (p < 0.05), and normal again at 4 weeks. There were no significant differences in flare increase between eyes with and without retinal breaks, eyes with and without limited retinal detachment, eyes with myopia more and less than -8.0 D, and eyes with a treatment area limited to one quadrant and extending over more than one quadrant. CONCLUSION: Transconjunctival cryosurgery caused mild inflammation in the anterior chamber of the eye for 3 weeks. The inflammation was not affected by the presence of retinal break or limited retinal detachment, the degree of myopia, or the extent of the treatment area.

Air pump for retinal detachment with macular hole.

From 1984 to 1992, 128 eyes with substantial retinal detachment due to macular hole underwent vitrectomy at the Ideta Eye Hospital. In the first 76 eyes treated, air was injected by syringe after removal of the vitreous (group A); in the subsequent 52 eyes, air was injected by a pump while subretinal fluid was aspirated through the macular hole (group B). The rates of retinal reattachment after the first surgery were 63.2% in group A and 82.7% in group B (P < .05). Thus, using the air pump was more effective than air injection.

[Statistical study of aqueous flare in rhegmatogenous retinal detachment].

Inflammation of the anterior chamber in rhegmatogenous retinal detachment was studied in 338 eyes with a laser flare cell meter. The mean flare value, 32.84 +/- 81.39 pc/msec, was significantly higher (p < 0.0001) than the 5.01 +/- 2.05 pc/msec of the control group of 133 normal eyes. Clinical findings of retinal detachment were grouped into 11 factors and each factor was divided into 34 details. The following details were proven by t-test to cause significant elevation of the flare value: (1) duration of more than 3 months, (2) hypotony of less than 9 mmHg, (3) aphakia, (4) retinal breaks in the ora area or the posterior area, (5) extension of retinal detachment with more than 2 quadrants, and (6) choroidal detachment. The correlation coefficients of the 6 clinical factors showed significant elevation of flare value in the following order: (1) presence or absence of choroidal detachment (0.396), (2) extension of retinal detachment (0.375), (3) intraocular pressure (-0.28), (4) duration of retinal detachment (0.18), (5) location of the break (0.15), and (6) presence or absence of the lens (0.134).

Three-dimensional architecture of elastic tissue in athero-arteriosclerotic lesions of the rat aorta.

The overall three-dimensional architecture of elastic tissue in athero-arteriosclerotic lesions of the ascending aorta of the rat was studied, using scanning electron microscopy (SEM), after hot-formic acid extraction followed by a freeze-drying method. The lesions were induced by feeding the rats a diet containing 2% cholesterol for 6 weeks and administering massive doses of vitamin D2 for the first 4 days. SEM revealed the synthesis of elastins mainly in the intima and the degradation in the internal elastic lamina (IEL) and medial concentric elastic lamellae. Intimal elastic elements involved in atherosclerotic lesions were composed of an intricately tangled network of fibrous elastins or a row of elastic laminae that surrounded many rectangular compartments, which were separated by fenestrated septum-like elastins and were assumed to be the sites of smooth-muscle-cell proliferation. These observations indicated remodelling of the elastic laminae in the intima. Degradation in the IEL and media was attributed to either vitamin D2 intoxication, which was characterized by the formation of a large degraded portion, or an enhanced elastolytic process. These alterations of elastic elements probably reflect the exact frame of the modes of migration of aortic smooth muscle cells in the development of athero-arteriosclerotic lesions, thereby indicating the role of smooth muscle cells in the progress of atherosclerosis.

Three-dimensional architecture of elastic tissue in early atherosclerotic lesions of the rat aorta.

The overall three-dimensional architecture of elastic tissue in early atherosclerotic lesions of the rat aorta was studied using scanning electron microscopy (SEM) after hot-formic acid extraction followed by a freeze-drying method. These lesions were induced by feeding the rats a diet containing 2% cholesterol, 0.5% cholic acid and 0.2% methylthiouracil. SEM revealed two types of alterations in the elastic tissue; one was an increase in the dome-like elastic lamina with few fenestrations that might be due to the reduplication of the internal elastic lamina (IEL), and the other was an increase in fibrous elastin, generally oriented longitudinally in the intima. The former was discussed with respect to its barrier function to such macromolecules as fibrinogen and low density lipoprotein (LDL), and was assumed to be a structure related to prevention of early atherosclerotic lesions.