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1.
Sci Rep ; 12(1): 2424, 2022 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-35165348

RESUMO

Optical control of the spin degree of freedom is often desired in application of the spin technology. Here we report spin-rotational excitations observed through inelastic light scattering of the hexagonal LuMnO3 in the antiferromagnetically (AFM) ordered state. We propose a model based on the spin-spin interaction Hamiltonian associated with the spin rotation of the Mn ions, and find that the spin rotations are angularly quantized by 60°, 120°, and 180°. Angular quantization is considered to be a consequence of the symmetry of the triangular lattice of the Mn-ion plane in the hexagonal LuMnO3. These angularly-quantized spin excitations may be pictured as isolated flat bubbles in the sea of the ground state, which may lead to high-density information storage if applied to spin devices. Optically pumped and detected spin-excitation bubbles would bring about the advanced technology of optical control of the spin degree of freedom in multiferroic materials.

2.
Implant Dent ; 26(6): 868-874, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29053486

RESUMO

PURPOSE: To retrospectively determine the profile of the sinus membrane (SM), potential factors affecting SM thickening (SMT), and the correlation between SMT and sinus augmentation (SA) complications. MATERIALS AND METHODS: In the patients who received lateral SA, SMT was classified in sagittal sections of cone-beam computed tomography according to its thickness and morphology. The correlation between SMT and the following factors was analyzed: age, sex, endodontic and periodontic statuses of neighboring teeth, and shape of the sinus inferior border. The association between SMT and SA complications was investigated. RESULTS: SMT of ≤2 mm was prevalent (60%). Irregular SM was mostly observed for SMT of >2 mm. There was no statistically significant association between SMT and the included factors. SMT did not significantly correlate with either perforation or postoperative complications. There was a statistically significant increase in implant failure when SMT was >2 mm, but it was hard to determine that the failure was solely affected by SMT. CONCLUSION: SMT was not influenced by the factors included in this study, and it might not be a risk factor for SA and implant failure.


Assuntos
Tomografia Computadorizada de Feixe Cônico , Seio Maxilar/diagnóstico por imagem , Seio Maxilar/patologia , Complicações Pós-Operatórias/diagnóstico por imagem , Levantamento do Assoalho do Seio Maxilar , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco
3.
Eur J Med Chem ; 136: 420-427, 2017 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-28527405

RESUMO

A set of fused ring analogues of a new antitubercular agent, Q203, was designed and synthesized. To reduce the lipophilicity of Q203 caused by linearly extended side chains, shorter and heteroatoms containing fused rings were introduced into the side chain region. Antitubercular activity was tested against H37Rv-GFP replicating in liquid broth culture medium (extracellular) and within macrophages (intracellular). Many analogues showed potent extracellular activities as well as intracellular activities without cytotoxicity. Among them, compounds 18-21 displayed significant antitubercular activities with favorable metabolic stabilities. Representative compound 21 exhibited excellent in vivo pharmacokinetic values at high drug exposure levels in the plasma, which makes this compound promising candidate for a new antitubercular drug.


Assuntos
Antituberculosos/farmacologia , Imidazóis/farmacologia , Mycobacterium tuberculosis/efeitos dos fármacos , Piperidinas/farmacologia , Piridinas/farmacologia , Animais , Antituberculosos/síntese química , Antituberculosos/química , Relação Dose-Resposta a Droga , Humanos , Imidazóis/síntese química , Imidazóis/química , Macrófagos/efeitos dos fármacos , Macrófagos/microbiologia , Testes de Sensibilidade Microbiana , Estrutura Molecular , Piperidinas/síntese química , Piperidinas/química , Piridinas/síntese química , Piridinas/química , Ratos , Relação Estrutura-Atividade
4.
Sci Rep ; 5: 13366, 2015 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-26300075

RESUMO

Spin-wave (magnon) scattering, when clearly observed by Raman spectroscopy, can be simple and powerful for studying magnetic phase transitions. In this paper, we present how to observe magnon scattering clearly by Raman spectroscopy, then apply the Raman method to study spin-ordering and spin-reorientation transitions of hexagonal manganite single crystal and thin films and compare directly with the results of magnetization measurements. Our results show that by choosing strong resonance condition and appropriate polarization configuration, magnon scattering can be clearly observed, and the temperature dependence of magnon scattering can be simple and powerful quantity for investigating spin-ordering as well as spin-reorientation transitions. Especially, the Raman method would be very helpful for investigating the weak spin-reorientation transitions by selectively probing the magnons in the Mn(3+) sublattices, while leaving out the strong effects of paramagnetic moments of the rare earth ions.

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