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1.
HLA ; 101(6): 660-663, 2023 06.
Artigo em Inglês | MEDLINE | ID: mdl-36961363

RESUMO

Forty novel HLA class I and class II alleles were identified in umbilical cord blood (UCB) samples and categorized based on various types of mutations: non-synonymous, synonymous, frameshift, and premature termination codon. This study described 14 novel HLA-A alleles, 9 novel HLA-B alleles, 4 novel HLA-C alleles, 3 novel HLA-DRB1 alleles and 10 novel HLA-DQB1 alleles. Comparing the new allele sequence with the most homologous sequence, 60% of the novel alleles exhibited non-synonymous substitution, 32.5% observed with synonymous substitution, 5% displayed premature stop codon, and 2.5% presented with frameshift mutation. The majority of the new alleles contained a single nucleotide variation when compared with the most similar sequence.


Assuntos
Sangue Fetal , Genes MHC Classe I , Humanos , Alelos , Cadeias beta de HLA-DQ/genética , Cadeias HLA-DRB1/genética , Antígenos HLA-C/genética
2.
HLA ; 93(2-3): 117-119, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30614223

RESUMO

Identification of the novel allele HLA-B*40:379 carrying polymorphisms in an intron, exon and the 3' untranslated region.


Assuntos
Alelos , Antígeno HLA-B40/genética , Sequenciamento de Nucleotídeos em Larga Escala , Regiões 3' não Traduzidas/genética , Sequência de Bases , Éxons/genética , Humanos
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