RESUMO
Thirty-three children with urinary calculi were studied. In 12, a metabolic cause of calculi was identified (4 hyperoxaluria, 6 hypercalciuria, 2 cystinuria). In 14 children, lithiasis was associated with a urinary tract infection. No identifiable cause could be found in 7 children. A protocol for metabolic evaluation is proposed.
Assuntos
Cálculos Urinários/etiologia , Adolescente , Cálcio/urina , Criança , Pré-Escolar , Feminino , Humanos , Hiperoxalúria/complicações , Lactente , Recém-Nascido , Masculino , Cálculos Urinários/metabolismo , Infecções Urinárias/complicaçõesRESUMO
The authors describe a boy with precocious puberty due to adrenal hyperplasia associated with rickets, hypocalcemia, hyperphosphatemia, elevated PTH and alkaline phosphatase levels, and concentrations of 25-OH-D and 1,25-(OH)2D at the upper limit or above normal range. Treatment with hydrocortisone for 9 months did not normalize hypocalcemia and hyperphosphatemia. The addition of 1,25-(OH)2D3 (0.5-2 micrograms/day) to the corticoid treatment for 1 year was followed by a progressive normalization of plasma calcium, phosphorus, PTH and alkaline phosphatase concentrations with improvement of the osteomalacia on bone biopsy.
Assuntos
Hiperplasia Suprarrenal Congênita/complicações , Raquitismo/complicações , Hiperplasia Suprarrenal Congênita/sangue , Hiperplasia Suprarrenal Congênita/tratamento farmacológico , Calcitriol/sangue , Calcitriol/uso terapêutico , Criança , Humanos , Hidrocortisona/uso terapêutico , Masculino , Hormônio Paratireóideo/sangue , Raquitismo/sangue , Raquitismo/tratamento farmacológicoRESUMO
A 2 year-old girl presented with bacterial meningitis followed by a lupus erythematosus syndrome consisting of erythematous rash, Raynaud's phenomenon and mutilating cicatricia atrophy; high speckled antinuclear antibodies and anti-Sm and anti-Ro antibodies titers; a selective absence of C4; moderate mesangial proliferation with IgM and C1q mesangial deposits. Study of the family revealed a linkage of C4 deficiency with the HLA A1 B17/BfF haplotype.