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1.
J Protozool ; 28(2): 167-70, 1981 May.
Artigo em Inglês | MEDLINE | ID: mdl-7277255

RESUMO

The effect of holothurin (a marine biotoxin) on the resistance of mice to trypanosoma musculi was measured by studying changes in the parasite population in vivo. Swiss Webster (SW), Beige (BG), and Black (BL) mice treated with holothurin prior to and simultaneously with infection of trypanosomes had lower parasitemias than controls. Higher levels of parasitemia were observed in mice treated after infection with trypanosomes. The timing of administration of holothurin appeared to be an important factor in the observed effect. The minor variations in the parasitemia seemed to be related to the mouse strain.


Assuntos
Holoturina/farmacologia , Saponinas/farmacologia , Tripanossomíase/imunologia , Animais , Imunidade , Masculino , Camundongos , Fatores de Tempo , Trypanosoma/crescimento & desenvolvimento , Tripanossomíase/sangue
6.
Pharmacology ; 14(5): 390-6, 1976.
Artigo em Inglês | MEDLINE | ID: mdl-1031213

RESUMO

Seven 1-(naphth-1-ylacetyl)-4-substituted thiosemicarbazides were synthesized and cyclized to the corresponding 2-(naphth-1-ylmethyl)-5-arylamino-1,3,4-oxadiazoles. All compounds, with the exception of two slbstituted oxadiazoles, possessed low anti-inflammatory activity. The protection afforded by these compounds against carrageen-in-induced edema ranged from 3 to 43% where cyclization, in general, decreased anti-inflammatory activity. All compounds (1 mM), possessed antiproteolytic activity where in vitro protection of trypsin-induced hydrolysis of bovine serum albumin, in most cases was greater with oxadiazoles.


Assuntos
Anti-Inflamatórios , Edema/tratamento farmacológico , Oxidiazóis/uso terapêutico , Soroalbumina Bovina/metabolismo , Tiossemicarbazonas/uso terapêutico , Animais , Carragenina , Avaliação Pré-Clínica de Medicamentos , Edema/induzido quimicamente , Hidrocortisona/uso terapêutico , Hidrólise , Oxidiazóis/metabolismo , Oxifenilbutazona/uso terapêutico , Ratos , Salicilato de Sódio/metabolismo , Tiossemicarbazonas/metabolismo , Tripsina/farmacologia
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