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Pharmacol Res ; 48(6): 551-6, 2003 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-14527818

RESUMO

Gymnema montanum is widely used in ancient medicine for the ailment of various diseases. Oral administration of 200 mg kg(-1) (body weight) BW of the alcoholic extract of the leaf for 3 weeks resulted in a significant reduction in blood glucose and an increase in plasma insulin, whereas the effect of 50 and 100 mg kg(-1) BW was not significant. The alcoholic extract also resulted in decreased free radical formation in plasma of diabetic rats. Thus, this study shows that Gymnema montanum leaf extract (GLEt) possess antihyperglycemic and antiperoxidative effect. The decrease in lipid peroxides and increase in reduced glutathione (GSH), ascorbic acid (Vitamin C) and alpha-tocopherol (Vitamin E) clearly show the antioxidant properties of GLEt. The effect of GLEt was most prominently seen in the case of animals given 200 mg kg(-1) BW. In addition, the results suggest that GLEt was highly effective than the reference drug glibenclamide.


Assuntos
Diabetes Mellitus Experimental/tratamento farmacológico , Gymnema , Extratos Vegetais/farmacologia , Folhas de Planta/química , Animais , Antioxidantes/farmacologia , Ácido Ascórbico/sangue , Glicemia/efeitos dos fármacos , Glicemia/metabolismo , Peso Corporal/efeitos dos fármacos , Diabetes Mellitus Experimental/sangue , Diabetes Mellitus Experimental/fisiopatologia , Ingestão de Alimentos/efeitos dos fármacos , Radicais Livres/sangue , Glutationa/sangue , Glibureto/farmacologia , Peróxido de Hidrogênio/sangue , Hipolipemiantes/farmacologia , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , Estresse Oxidativo/efeitos dos fármacos , Fitoterapia , Extratos Vegetais/uso terapêutico , Ratos , Ratos Wistar , Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
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