RESUMO
The effect of poly-unsaturated and saturated fatty acid-rich diet on the proliferation response of T and B lymphocytes in vitro was investigated. Also, a mitotic index of thymocytes and of thymus epithelial reticular-like cells and thymic involution coefficient were examined in vivo. w-6 PUFA-rich diet enhanced the rate of T (eightfold) and B (fourfold) lymphocyte proliferation, whereas saturated fatty acids did not show an important effect. However, both fat-rich diets increased the mitotic index of thymocytes and thymus involution index in vivo. These findings suggest that fat-rich diets may accelerate thymus involution during growing, possibly aggravating the impairment of the immune function which usually occurs under this condition.
Assuntos
Envelhecimento/imunologia , Linfócitos B/imunologia , Gorduras na Dieta/toxicidade , Ácidos Graxos/administração & dosagem , Ativação Linfocitária/imunologia , Linfócitos T/imunologia , Timo/imunologia , Animais , Tolerância Imunológica/imunologia , Contagem de Leucócitos , Masculino , Índice Mitótico , Ratos , Ratos WistarRESUMO
Monosodium glutamate (MSG) has been shown to alter several neuroendocrine functions in neonatally treated rats. To evaluate possible alterations in lipogenesis rate and lipoprotein lipase (LPL) activity, male and female rats were injected during the neonatal period with MSG or saline (controls). In male MSG rats, an increase in lipogenesis of liver and retroperitoneal adipose tissues was observed. Triton WR 1339 (an LPL inhibitor) administration decreased retroperitoneal lipogenesis in these animals. In female rats, MSG-treatment increased lipogenesis only in gonadal and retroperitoneal adipose tissues. No change was observed in hepatic lipogenesis and the Triton administration did not change retroperitoneal lipogenesis. LPL activity was increased in the gonadal and retroperitoneal adipose tissues in male and female MSG-treated rats. These data suggest that there is a specific sex-dependent response in the development of MSG-induced obesity.
Assuntos
Tecido Adiposo/efeitos dos fármacos , Lipídeos/biossíntese , Lipase Lipoproteica/metabolismo , Glutamato de Sódio/farmacologia , Tecido Adiposo/metabolismo , Animais , Animais Recém-Nascidos , Feminino , Fígado/efeitos dos fármacos , Fígado/metabolismo , Masculino , Ovário/efeitos dos fármacos , Ovário/metabolismo , Polietilenoglicóis/farmacologia , Gravidez , Ratos , Ratos Endogâmicos , Espaço Retroperitoneal , Glutamato de Sódio/administração & dosagem , Testículo/efeitos dos fármacos , Testículo/metabolismoRESUMO
Ethanol intake during lactation causes growth deficiency and decreased plasma and liver protein content in pups. The lipid content of pup liver and brain was similar to that of the control group. Mammary gland protein content decreased, but the rate of lipogenesis in this gland was increased. This fact may be relevant to an adequate supply of lipid substrate to the pups.
