Efficacy and safety of alpha-pinene capsule in the management of functional dyspepsia and eradication of helicobacter pylori: a randomized clinical trial.

Aim: Our objective was to assess the efficacy and safety of adding alpha-pinene (a herbal terpenoid) to quadruple therapy compared to a placebo in improving symptoms and Helicobacter pylori (H. pylori) eradication rates in Functional dyspepsia (FD) patients. Background: FD is a prevalent upper gastrointestinal condition, and no definitive pharmacological treatment is available for its management. Methods: We conducted a randomized, double-blinded, placebo-controlled trial on FD patients diagnosed with H. pylori infection. We collected baseline demographic data and assessed FD symptoms in the participants. Patients were randomly allocated to receive either standard quadruple therapy with α-pinene capsules (0.25 mg/day) or quadruple therapy with a placebo for two weeks. We employed a validated questionnaire, the Short Form Leeds Dyspepsia Questionnaire (SF-LDQ), to evaluate FD symptoms. The eradication rate of H. pylori was compared between the two groups one month after completing the treatment regimens. Any reported adverse drug reactions (ADRs) were documented throughout the trial. Results: Over four months, a total of 66 patients completed the trial. Notably, there were no significant differences in baseline SF-LDQ scores between the two groups (p=0.83); however, a significant divergence emerged at the trial's conclusion (p=0.03). The H. pylori eradication rates did not show notable differences between the two treatment arms (p=0.43). Importantly, there were no dropouts from the trial due to ADRs. Among reported ADRs, participants experienced abdominal pain, headache, diarrhea, and a metallic taste, with no significant variance in incidence rates observed between the two groups (p=0.62). Conclusion: These findings suggest that α-pinene could be an effective and safe agent for reducing FD symptoms.

Comparative evaluation of nutrient composition, in vitro nutritional value, and antioxidant activity of de-oiled meals from walnut, hazelnut, almond, and sesame.

This study aimed to establish a comparative database on the chemical composition, in vitro nutritional value, and antioxidant activity of the de-oiled meals produced from walnut, hazelnut, almond, and sesame seeds from the ruminant nutrition perspective. The meals were provided in dried form after their oil harvest using the cold-pressing oil extraction method. Crude protein (CP) constituted the major component of the meals and was the greatest in walnut and almond (average of 45.6% of dry matter (DM)], intermediate in hazelnut meal (41.4%), and least in sesame meal (33.3%)). Potassium was the most abundant mineral in walnut, hazelnut, and almond meals, followed by phosphorus, calcium, and magnesium. The CP fractions determined using the Cornell Net Carbohydrate and Protein System were largely different across the meals, with fraction A being the greatest in hazelnut (40.9% of CP) and intermediate in almond, sesame, and walnut meals (11.4% of CP). The unavailable CP fraction (fraction C) was the least abundant fraction in all meals, ranging from 0.13% of CP in walnut to 3.30% of CP in hazelnut meal. Oleic and linoleic acids were the predominant unsaturated fatty acids, and palmitic acid was the principal fatty acid in all meals analyzed. The fractional degradation rate (h-1) ranged from 0.043 in almond meal to 0.017 in walnut meal. In vitro intestinal CP digestibility (% of rumen-undegraded protein) ranged from 91.6 in hazelnut meal to 97.2 in almond meal. Total phenolics expressed as milligram tannic acid equivalent/gram DM was greatest in walnut meal (11.9), resulting in the greatest antioxidant activity recorded for walnut meal (83.2%). This study provided a database on the nutrient composition, in vitro nutritional value, and antioxidant capacity of the selected de-oiled meals. Additional investigation is needed to identify the in vivo response of their inclusion in the diet of ruminants.