RESUMO
The goal of this study was to determine the effect of oral melatonin in divided doses on plasma melatonin levels in patients with metastatic melanoma. Hourly blood samples were obtained from five patients for 24 h prior to melatonin administration and for 24 h during oral administration of melatonin, 50 mg every 4 h. In two of the five patients, the expected nocturnal plasma melatonin peak was observed. Oral melatonin was well absorbed. Plasma melatonin levels exhibited six peaks and troughs, were two to four-fold higher during peaks than troughs, and remained more than 25 times higher than peak pretreatment melatonin levels, even during troughs. Divided oral doses of melatonin were well tolerated and maintained plasma melatonin levels 25-80 times higher than endogenous peak values.
Assuntos
Melanoma/sangue , Melatonina/administração & dosagem , Melatonina/sangue , Administração Oral , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Ritmo Circadiano , Feminino , Humanos , Individualidade , Masculino , Melanoma/tratamento farmacológicoAssuntos
Nêutrons , Radiometria , Berílio , Cobalto , Matemática , Ciência de Laboratório Médico , RadioterapiaRESUMO
PIP: The 2 themes of this century, increasing environmental fragility and increasing human demands on government, are underlined by the failure of government to effectively govern, and the complex technology and modern communication systems which further divide the developing nations from the developed ones. Population stabilization may help relieve the tension between increasing expectation from government and the fiscal bind in 3 ways: 1)a higher per capita income would increase per capita government revenue which would have a better chance of meeting citizen expectations, 2)a moderately redistributive effect on personal income might occur by decreasing unwanted fertility through the dynamics of economics and increasing the role of government in elevating living standards, and 3)with reduction of government expenditure per capita, the cost of providing any given level of service would decrease. The nuclear age has altered the concept of what constitutes national security. Rapid population growth in the developing countries is also significant, and the United States economy depends on overseas investment. A constructive foreign policy, as opposed to neoimperialism or isolationism, is recommended to help influence world population growth.^ieng
