RESUMO
Dental caries and trauma, particularly in childhood, are among the most prevalent teeth problems, which result in the creation of cavities and probably tooth loss. Thus, novel regenerative approaches with high efficiency and less toxicity are required. Stem cell therapy along with the implementation of scaffolds has provided excellent opportunities in the regeneration of teeth structure. Hyaluronic acid (HA) hydrogels have enticed great attention in the field of regenerative medicine. The unique chemical and structural properties of HA and its derivatives have enabled their application in tissue engineering. Several factors such as the location and type of the lesion, teeth age, the type of capping materials determine the success rate of pulp therapy. HA hydrogels have been considered as biocompatible and safe scaffold supports in human dental cell therapies.
Assuntos
Cárie Dentária/terapia , Polpa Dentária/fisiologia , Ácido Hialurônico/farmacologia , Hidrogéis/farmacologia , Engenharia Tecidual , Materiais Biocompatíveis/química , Materiais Biocompatíveis/farmacologia , Diferenciação Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Polpa Dentária/ultraestrutura , Humanos , Ácido Hialurônico/química , Hidrogéis/química , Medicina Regenerativa , Transplante de Células-Tronco , Células-Tronco/efeitos dos fármacos , Células-Tronco/fisiologia , Alicerces Teciduais , Dente/fisiologia , Dente/ultraestruturaRESUMO
Nanoscale particles and molecules are a potential different for the treatment of disease because they have distinctive biologic property based on their structure and size, which is different from traditional small-molecule drugs. The antimicrobial mechanisms of silver nanoparticles include the formation of free radicals damaging the bacterial membranes, interactions with DNA, adhesion to cell surface altering the membrane properties, and enzyme damage. In this review, we focus on applications of silver nanoparticles in inhibition of herpes simplex virus.
Assuntos
Antivirais/química , Antivirais/farmacologia , Nanopartículas Metálicas , Prata/química , Prata/farmacologia , Simplexvirus/efeitos dos fármacos , Herpes Simples/epidemiologia , Herpes Simples/etiologia , Humanos , Simplexvirus/fisiologiaRESUMO
Through the present paper, a triblock copolymer containing pH-responsive (polyacrylic acid-b-polycaprolactone -b-polyacrylic acid) (PAA-b-PCL-b-PAA) was synthesized by using the ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) and the reversible addition fragmentation chain transfer (RAFT) polymerization of the acrylic acid methods, as the drug carrier. Blends of the nanocrystalline zinc oxide nanoparticles (n-ZnO) and triblock copolymer treated from the solution have been used to make the hybrid polymer-metal oxide for the preparation of the drug loaded nanocomposite. The drug-release behavior of the nanocomposite was studied by using the Doxorubicin as a model drug. In addition to the self-assembly and pH-responsive behavior of the triblock copolymers/ZnO was studied in solution by the Fluorescence Spectroscopy, Scanning Electron Microscopy(SEM), Transmission Electron Microscopy (TEM), DLS, HNMR and FT-IR spectroscopy.
