Vaginoscopic resection of hemivagina, in a 20-year-old virgin female with prior misdiagnosis of OHVIRA syndrome as a bicornuate uterus: A case report.

Key Clinical Message: OHVIRA syndrome can be misdiagnosed due to its rarity, resulting in the need for more invasive interventions than vaginoscopy. Also, delayed diagnosis of OHVIRA syndrome can affect patient's quality of life by leading to chronic gynecological diseases such as endometriosis and pelvic inflammatory disease. Abstract: Obstructive hemivagina and ipsilateral renal agenesis (OHVIRA) syndrome is one of the infrequent congenital Mullerian duct anomalies characterized by obstructed hemivagina and ipsilateral renal agenesis. This study presents a 20-year-old virgin female who was diagnosed with OHVIRA syndrome and treated by vaginoscopy using the hymen preservation technique. Also, she was misdiagnosed with non-communicating rudimentary uterine horn 4 years ago. Late or misdiagnosis of OHVIRA syndrome can affect fertility and pregnancy outcomes. Therefore, early diagnosis and management are crucial. OHVIRA syndrome's misdiagnosis is possible with other Mullerian duct anomalies, such as a rudimentary uterine horn. Also, patients with misdiagnosis undergo unnecessary interventions.

OPTIMIZATION OF LUNG CT PROTOCOL FOR THE DIAGNOSTIC EVALUATION OF COVID-19 LUNG DISEASE.

This study intends to evaluate the different lung CT scan protocols used for the diagnostic evaluation of COVID-19-induced lung disease in Iranian imaging centers in terms of radiation dose and image quality. After data collecting, subjective image quality, radiation dose and objective image quality such as noise, SNR and CNR were assessed. Statistically significant differences in effective dose and image quality were evident among different lung CT protocols. Lowest and highest effective dose was1.31 ± 0.53 mSv related to a protocol with activated AEC (reference mAs = 20) and 6.15 ± 0.57 mSv related to a protocol with Fixed mAs (mAs = 100), respectively. A protocol with enabled tube current modulation with 70 mAs as a reference mAs, and protocol with 20 mAs and enabled AEC had the best and lowest image quality, respectively. To optimize the scan parameters, AEC must be used, and a range of tube currents (between 20 and 50 mAs) can produce acceptable images in terms of diagnostic quality and radiation dose for the diagnosis of COVID-19-induced lung disease.

The effects of memantine on the serum concentrations of matrix metalloproteinases and neurologic function of patients with ischemic stroke.

Memantine was suggested as a promising treatment for stroke due to its neuroprotective property and efficacy in reducing ischemic brain injury and improving post-ischemic neurological recovery. This pilot, open-label, randomized clinical trial was conducted to investigate the impact of memantine on serum concentrations of matrix metalloproteinases (MMP)-2 and MMP-9, as neuronal damage biomarkers, and neurologic function evaluated by the National Institute of Health Stroke Scale(NIHSS) and Barthelindex(BI) in patients with ischemic stroke. Admitted patients with mild to moderate ischemic stroke were assessed for eligibility, and eligible patients were randomized to the intervention or control group. Enrolled patients in the intervention group received 20 mg memantine every 8 h for five days and then 20 mg daily for three months. Both groups managed with the standard treatments. From 77 randomized patients, 29 participants in the control group and 24 patients in the intervention group completed the study. Data showed that the increase in the serum concentrations of MMP-9 within the first 5 days of the study was significantly lower in the intervention group (P = 0.005). This effect of memantine on the MMP-2 was not significant (P = 0.448). memantine also could significantly improve the neurologic function of the patients according to NIHSS (P < 0.0001) and BI (P = 0.002) during hospitalization and after that. In conclusion, memantine could be considered as a neuroprotective agent in patients with mild to moderate ischemic stroke, based on its significant effects on reducing brain damage and improving neurologic function of the patients.

Sulfonated chitosan as green and high cloud point kinetic methane hydrate and corrosion inhibitor: Experimental and theoretical studies.

In this work sulfonated chitosan (SCS) was introduced as a promising green kinetic methane hydrate and corrosion inhibitor to overcome the incompatibility problem between inhibitors. Evaluation of hydrate inhibition performance of SCS with high-pressure autoclave and micro-differential scanning calorimeter revealed that hydrate formation was delayed 14.3 ±â€¯0.2 times and amount of hydrate formed was decreased to 30 % compared to water. The weight loss experiments showed that SCS provides corrosion inhibition efficiency of 95.6 ±â€¯0.1 at 5000 ppm concentration. SCS is able to increase polarization resistance and decrease corrosion current density according to electrochemical measurements. Study of surface morphology by SEM-EDX and profilometer showed that SCSs suppress corrosion rate and reduce the surface roughness of carbon steel. Quantum chemical study confirmed that the pendant groups caused by chitosan modification interact with carbon steel surface. The findings of this research can provide new opportunities to develop biodegradable materials as KHIs/CIs for flow assurance in oil and gas pipelines.

A new aqueous biphasic system containing polypropylene glycol and a water-miscible ionic liquid.

In this work, we proposed a novel aqueous biphasic system (ABS) composed of polypropylene glycol P400 (PPG P400) and hydrophilic ionic liquids (IL), 1-alkyl-3-methylimidazolium bromide (alkyl = ethyl or butyl), forming an upper polymer-rich phase and a lower IL-rich phase at ambient temperature. This new ABS can present interesting characteristics shared by ILs and polymers such as low volatility, good solvation ability, tunable physical properties, and high design capacity for achieving task-specific phase components to enhance the partitioning of target species. Ternary phase diagram of the novel ABS formed by PPG 400 and [C(2) mim]Br in water was measured at T = 298.15 K. Factors affecting the binodal curves such as the cation side alkyl chain length and the temperature were also evaluated. The results were successfully interpreted in terms of the kosmotropic/chaotropic nature of ILs. Furthermore, the phase behavior of the PPG-[C(2) mim]Br ABS is described by the NRTL model. Finally, the extraction potential of the proposed ABS was evaluated through its application to the extraction of the essential amino acids such as L-tryptophan and L-tyrosine. The partition coefficients here obtained demonstrated the fine potential of the proposed ABS for biomolecules separation.