INTRA-OPERATIVE NEED FOR GLUCOSE IN NEWBORNS.

INTRODUCTION: One ofthe important goals of intraoperativefluid therapy in neonates is to ensure normal glycemic status. However there is no definitive guidance on the issue of intraoperative administration solutions containing glucose. MATERIALS AND METHODS: a single-center study of intraoperative glycemic status in 60 newborns with congenital malformations was conducted. Age at the time of surgery amounted to Me 48 [24; 120] hours of life, the duration of surgery was 70 [60; 101] minutes. The children were divided into two groups: in group 1 (n = 30) intraoperative infusion therapy was only saline; in group 2 (n = 30) with salt solutions were simultaneously injected glucose in a dose of 2,3 mg/kg/ min. The glucose level in the blood was evaluated before operation, during operation every 30 minutes and at the end of surgical intervention, if it was necessary, was corrected. RESULTS: the study revealed high incidence of hypoglycemic conditions in children in group 1, especially during tracheal intubation and skin incision (40 episodes in 20 children). However the blood glucose level subsequently normalized and remained within the reference values. In group 2, the average glucose level in these stages was significantly greater than 4,4 [3,3; 5,2] mmol/l (p = 0,03), and did not go beyond normal values, remaining stable in all phases of the operation. There was a decrease in 2 times the frequency of episodes of hypoglycemia in group 2 (19 episodes in 12 patients). At the same time, more often fixed hyperglycemia in group 2. CONCLUSIONS: intraoperative blood glucose in newborns is unstable indicator and requires a precise dosing of glucose in the infusion to avoid Hypo- and hyperglycemia.

Biochemical and neurotransmitters changes associated with tramadol in streptozotocin-induced diabetes in rats.

The incidence of diabetes is increasing worldwide. Chronic neuropathic pain occurs in approximately 25% of diabetic patients. Tramadol, an atypical analgesic with a unique dual mechanism of action, is used in the management of painful diabetic neuropathy. It acts on monoamine transporters to inhibit the reuptake of norepinephrine (NE), serotonin (5-HT), and dopamine (DA). The purpose of this study was to evaluate the effects of diabetes on the brain neurotransmitter alterations induced by tramadol in rats, and to study the hepatic and renal toxicities of the drug. Eighty Sprague-Dawley rats were divided randomly into two sets: the normal set and the diabetic set. Diabetes was induced in rats. Tramadol was administered orally once daily for 28 days. The levels of DA, NE, and 5-HT in cerebral cortex, thalamus/hypothalamus, midbrain, and brainstem were evaluated in rats. In addition, the renal toxicity and histopathological effects of the drug were assessed. The induction of diabetes altered neurotransmitter levels. Oral administration of tramadol significantly decreased the neurotransmitter levels. Diabetes significantly altered the effects of tramadol in all brain regions. Tramadol affected function and histology of the liver and kidney. The clinical effects of tramadol in diabetic patients should be stressed.

Numerical conformal mapping and its inverse of unbounded multiply connected regions onto logarithmic spiral slit regions and straight slit regions.

This paper presents a boundary integral equation method with the adjoint generalized Neumann kernel for computing conformal mapping of unbounded multiply connected regions and its inverse onto several classes of canonical regions. For each canonical region, two integral equations are solved before one can approximate the boundary values of the mapping function. Cauchy's-type integrals are used for computing the mapping function and its inverse for interior points. This method also works for regions with piecewise smooth boundaries. Three examples are given to illustrate the effectiveness of the proposed method.

Experimental investigation of pneumatic soil vapor extraction.

Soil Vapor Extraction (SVE) is a common remediation technique for removing volatile organic compounds from unsaturated contaminated soils. Soil heterogeneities can however cause serious limitations to the applicability of SVE due to air bypassing low permeable areas of the soil, leading to diffusion limitation of the remediation. To enhance removal from areas subject to diffusion limitation a new remediation technique, pneumatic soil vapor extraction, is proposed. In contrast to traditional SVE, in which soil vapor is extracted continuously by a vacuum pump, pneumatic SVE is based on enforcing a sequence of large pressure drops on the system to enhance the recovery from the low-permeable areas. The pneumatic SVE technique was investigated in the laboratory using TCE as a model contaminant. 2D-laboratory tank experiments were performed on homogeneous and heterogeneous sand packs. The heterogeneous packs consisted of a fine sand lens surrounded by a coarser sand matrix. As expected when using traditional SVE, the removal of TCE from the low permeable lens was extremely slow and subject to diffusion limitation. In contrast when pneumatic venting was used removal rates increased by up to 77%. The enhanced removal was hypothesized to be attributed to mixing of the contaminated air inside the lens and generation of net advective transport out of the lens due to air expansion.

Evaluation of the in-vitro pediculicidal action of four known insecticides and three medicinal plant extracts.

Human lice is an increasing community health problem worldwide. This is particularly true among school children who spend most of their daytime in crowded areas. Four commercially known insecticides and three medicinal plant extracts were studied to evaluate their pediculicidal activities in-vitro. The best result with insecticides was achieved with malathion (Lt5o 10.396 and slope function 1.183). The best result with medicinal plant extracts was achieved with neem oil (A. indica) (Lt5o 85.27 and slope function 1.480). Although, neem oil extract was less active than malathion, yet it is more safe for human usage.

Scopulariopsis endocarditis associated with Duran ring valvuloplasty.

Fungal endocarditis is rare and is usually caused by Aspergillus and Candida species. We present a patient with endocarditis caused by Scopulariopsis brevicaulis. The patient had a history of mitral valve disease and, 1 year earlier, had undergone valvuloplasty with the placement of a prosthetic Duran ring in the mitral valve position. S. brevicaulis was cultured from samples of a large vegetation on the mitral valve apparatus. The mitral valve was replaced with a St. Jude mechanical prosthesis. The patient was treated with amphotericin B but was later switched to oral itraconazole when antibiotic tests indicated susceptibility to that agent. We believe this is the 1st reported case of endocarditis caused by Scopulariopsis.